STRINGSTRING
MAP2K6 MAP2K6 IL15 IL15 RPS6KA5 RPS6KA5 FOS FOS PIK3CB PIK3CB TRAF3 TRAF3 IL18R1 IL18R1 SOCS3 SOCS3 VEGFD VEGFD LOC110572667 LOC110572667 CEACAM16 CEACAM16 BCL3 BCL3 AKT1 AKT1 NFKB1 NFKB1 BAG4 BAG4 IKBKB IKBKB CREB3L4 CREB3L4 SELE SELE LOC110572744 LOC110572744 AKT3 AKT3 IKBKG IKBKG CCL20 CCL20 MAP3K14 MAP3K14 PIK3R2 PIK3R2 TNFRSF1B TNFRSF1B TRAF5 TRAF5 JUN JUN PTGS2 PTGS2 MAPK13 MAPK13 MAPK14 MAPK14 CREB3L1 CREB3L1 RELA RELA FADD FADD PIK3R3 PIK3R3 CEBPB CEBPB PIK3CD PIK3CD RPS6KA4 RPS6KA4 MAP3K8 MAP3K8 MAPK12 MAPK12 JAG1 JAG1 MMP9 MMP9 ATF4 ATF4 MAPK11 MAPK11 MAPK1 MAPK1 TAB1 TAB1 IL6 IL6 CREB5 CREB5 MAPK9 MAPK9 CSF1 CSF1 TNFRSF1A TNFRSF1A DNM1L DNM1L TRAF2 TRAF2 TRAF1 TRAF1 CREB3 CREB3 ITCH ITCH PGAM5 PGAM5 PIK3CA PIK3CA VCAM1 VCAM1 CREB3L2 CREB3L2 TNFAIP3 TNFAIP3 MAP3K5 MAP3K5 TAB2 TAB2 MAP3K7 MAP3K7 LOC110581877 LOC110581877 CASP3 CASP3 VEGFC VEGFC MAP2K3 MAP2K3 MMP14 MMP14 FAS FAS MMP10 MMP10 LOC110586166 LOC110586166 MMP12 MMP12 BIRC3 BIRC3 MAP2K4 MAP2K4 RIPK1 RIPK1 TNF TNF EDN1 EDN1 LTA LTA IFNB1 IFNB1 IL1B IL1B RIPK3 RIPK3 NFKBIA NFKBIA BIRC2 BIRC2 ATF6B ATF6B CHUK CHUK MAPK8 MAPK8 MAPK3 MAPK3 IRF1 IRF1 CASP7 CASP7 CSF2 CSF2 PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591461 LOC110591461 LOC110591392 LOC110591392 LOC110591473 LOC110591473 LOC110591476 LOC110591476 LOC110591463 LOC110591463 RFWD3 RFWD3 CREB1 CREB1 CASP10 CASP10 CFLAR CFLAR AKT2 AKT2 LOC110592974 LOC110592974 TRADD TRADD CCL5 CCL5 NOD2 NOD2 CASP8 CASP8 CXCL10 CXCL10 CREB3L3 CREB3L3 ICAM1 ICAM1 ATF2 ATF2 CX3CL1 CX3CL1 LIF LIF JUNB JUNB MAP2K7 MAP2K7 TAB3 TAB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
FOSProto-oncogene c-Fos. (380 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IL18R1Interleukin-18 receptor 1. (540 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (357 aa)
LOC110572667Interferon-inducible GTPase 5-like. (460 aa)
CEACAM16Carcinoembryonic antigen-related cell adhesion molecule 16. (424 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
BAG4BAG family molecular chaperone regulator 4. (457 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
SELEE-selectin. (609 aa)
LOC110572744Interferon-inducible GTPase 5. (464 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
CCL20C-C motif chemokine. (96 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B isoform X1. (464 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
RELATranscription factor p65. (531 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
IL6Interleukin-6 isoform X1. (212 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
DNM1LDynamin-1-like protein isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1. (289 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VCAM1Vascular cell adhesion protein 1. (776 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (795 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC110581877Disabled homolog 2-interacting protein isoform X1. (1065 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
FASTumor necrosis factor receptor superfamily member 6. (314 aa)
MMP10Stromelysin-2. (476 aa)
LOC110586166Stromelysin-1. (476 aa)
MMP12Macrophage metalloelastase. (470 aa)
BIRC3Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
EDN1Endothelin-1. (202 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
IFNB1Interferon beta. (182 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3 isoform X1. (532 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (619 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IRF1Interferon regulatory factor. (322 aa)
CASP7Caspase-7 isoform X1; Belongs to the peptidase C14A family. (301 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591461C-X-C motif chemokine. (105 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
LOC110591473C-X-C motif chemokine. (107 aa)
LOC110591476C-X-C motif chemokine. (113 aa)
LOC110591463C-X-C motif chemokine. (107 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3. (779 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (481 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC110592974C-C motif chemokine. (101 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (312 aa)
CCL5C-C motif chemokine. (91 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
CASP8LOW QUALITY PROTEIN: caspase-8; Belongs to the peptidase C14A family. (486 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CX3CL1Fractalkine. (436 aa)
LIFLeukemia inhibitory factor. (202 aa)
JUNBTranscription factor jun-B. (347 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (440 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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