STRINGSTRING
MAP3K3 MAP3K3 RAP1B RAP1B FRS2 FRS2 NTRK2 NTRK2 ERAS ERAS GAB1 GAB1 IRAK3 IRAK3 RPS6KA5 RPS6KA5 PIK3CB PIK3CB GCNA GCNA PSEN1 PSEN1 CALM1 CALM1 NTRK3 NTRK3 LOC110572425 LOC110572425 ARHGDIA ARHGDIA AKT1 AKT1 BAX BAX NFKB1 NFKB1 IKBKB IKBKB GRB2 GRB2 RPS6KA3 RPS6KA3 AKT3 AKT3 NTF4 NTF4 IRS1 IRS1 IRAK1 IRAK1 PIK3R2 PIK3R2 SHC1 SHC1 TP73 TP73 NTRK1 NTRK1 JUN JUN RPS6KA1 RPS6KA1 CALML6 CALML6 LOC110575329 LOC110575329 FASLG FASLG MAPKAPK2 MAPKAPK2 MAPK13 MAPK13 MAPK14 MAPK14 RELA RELA PIK3R3 PIK3R3 PIK3CD PIK3CD CDC42 CDC42 BCL2 BCL2 PPP1R14B PPP1R14B CAMK2D CAMK2D BAD BAD BDNF BDNF TRAF6 TRAF6 PRDM4 PRDM4 MAPK12 MAPK12 CRKL CRKL RIPK2 RIPK2 PLCG1 PLCG1 ATF4 ATF4 MAPK11 MAPK11 MAPK1 MAPK1 PSEN2 PSEN2 MAPK9 MAPK9 CSDE1 CSDE1 NGF NGF RAP1A RAP1A KRAS KRAS ABL1 ABL1 NRAS NRAS ZNF274 ZNF274 HRAS HRAS PIK3CA PIK3CA ARHGDIB ARHGDIB NTF3 NTF3 GSK3B GSK3B SORT1 SORT1 BRAF BRAF RPS6KA2 RPS6KA2 BEX3 BEX3 MAP3K5 MAP3K5 RAPGEF1 RAPGEF1 RPS6KA6 RPS6KA6 CEP152 CEP152 SHC4 SHC4 NFKBIE NFKBIE MAP2K1 MAP2K1 ZSCAN1 ZSCAN1 SHC3 SHC3 FOXO3 FOXO3 TP53 TP53 MAPK7 MAPK7 PRKCD PRKCD RAF1 RAF1 CSK CSK MAP2K5 MAP2K5 CALML4 CALML4 CALML5 CALML5 LOC110586587 LOC110586587 CAMK2A CAMK2A IRAK2 IRAK2 NFKBIA NFKBIA KIDINS220 KIDINS220 PDPK1 PDPK1 PTPN11 PTPN11 SH2B3 SH2B3 SOS1 SOS1 ARSI ARSI ARHGDIG ARHGDIG CAMK2G CAMK2G MAPK8 MAPK8 SH2B2 SH2B2 MAPK3 MAPK3 ZFR ZFR SOS2 SOS2 CAMK4 CAMK4 MAP3K1 MAP3K1 PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591392 LOC110591392 SH2B1 SH2B1 NFKBIB NFKBIB LOC110592156 LOC110592156 AKT2 AKT2 LOC110592210 LOC110592210 CAMK2B CAMK2B NGFR NGFR IRAK4 IRAK4 MAP2K2 MAP2K2 MATK MATK SHC2 SHC2 ZFR2 ZFR2 YWHAE YWHAE CRK CRK MAP2K7 MAP2K7 PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (626 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ERASGTPase ERas. (233 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (556 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GCNAAcidic repeat-containing protein. (442 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
ARHGDIARho GDP-dissociation inhibitor 1. (204 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (211 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (726 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (617 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
CALML6Calmodulin-like protein 6. (232 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (281 aa)
MAPKAPK2MAP kinase-activated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (402 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RELATranscription factor p65. (531 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CRKLCrk-like protein. (303 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
KRASGTPase KRas. (188 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
NRASGTPase NRas. (189 aa)
ZNF274Neurotrophin receptor-interacting factor homolog isoform X2. (587 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ARHGDIBRho GDP-dissociation inhibitor 2. (200 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SORT1Sortilin. (835 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
RPS6KA2Ribosomal protein S6 kinase. (727 aa)
BEX3Protein BEX3 isoform X1. (112 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ZSCAN1Zinc finger and SCAN domain-containing protein 1. (400 aa)
SHC3SHC-transforming protein 3. (469 aa)
FOXO3Forkhead box protein O3. (672 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
CSKTyrosine-protein kinase. (450 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (624 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1754 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
SH2B3SH2B adapter protein 3. (578 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
ARSIArylsulfatase I. (575 aa)
ARHGDIGRho GDP-dissociation inhibitor 3. (272 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SH2B2SH2B adapter protein 2. (937 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ZFRZinc finger RNA-binding protein. (1073 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (470 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1393 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
SH2B1SH2B adapter protein 1 isoform X3. (761 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X1. (354 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (419 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MATKTyrosine-protein kinase. (531 aa)
SHC2SHC-transforming protein 2. (551 aa)
ZFR2LOW QUALITY PROTEIN: zinc finger RNA-binding protein 2. (890 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (440 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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