STRINGSTRING
NRAS NRAS GNG14 GNG14 GNG7 GNG7 GNAO1 GNAO1 PRKACA PRKACA CACNA1A CACNA1A RAPGEF3 RAPGEF3 GNGT2 GNGT2 HTR1A HTR1A SLC6A4 SLC6A4 DDC DDC KCNJ3 KCNJ3 GABRB1 GABRB1 HTR7 HTR7 ALOX5 ALOX5 SLC18A2 SLC18A2 GNG2 GNG2 MAPK3 MAPK3 GABRB2 GABRB2 SLC18A1 SLC18A1 GNG13 GNG13 HTR2A HTR2A LOC110585772 LOC110585772 PLA2G4E PLA2G4E PLCB1 PLCB1 ALOX15B ALOX15B ALOX12B ALOX12B LOC110584449 LOC110584449 HTR3B HTR3B KCNJ5 KCNJ5 HTR3A HTR3A GNG4 GNG4 PLA2G4D PLA2G4D PLA2G4B PLA2G4B PLA2G4F PLA2G4F HTR1B HTR1B JMJD7 JMJD7 HTR4 HTR4 PLCB2 PLCB2 HTR5A HTR5A RAF1 RAF1 ITPR1 ITPR1 CACNA1D CACNA1D LOC110582495 LOC110582495 ALOX12 ALOX12 HTR3C HTR3C LOC110584496 LOC110584496 CASP3 CASP3 GNB5 GNB5 HTR1E HTR1E BRAF BRAF PRKACB PRKACB LOC110582613 LOC110582613 ADCY5 ADCY5 LOC110582484 LOC110582484 GNB4 GNB4 HRAS HRAS GNG5 GNG5 LOC110582001 LOC110582001 GNGT1 GNGT1 GNG10 GNG10 GNG11 GNG11 GNAS GNAS LOC110569839 LOC110569839 APP APP KCNJ6 KCNJ6 TPH2 TPH2 TRPC1 TRPC1 CACNA1F CACNA1F ERAS ERAS PRKCA PRKCA LOC110571781 LOC110571781 GNB2 GNB2 ARAF ARAF LOC110571954 LOC110571954 GNG8 GNG8 GNG12 GNG12 GABRB3 GABRB3 LOC110573035 LOC110573035 PLA2G4A PLA2G4A MAOA MAOA KCNJ9 KCNJ9 HTR6 HTR6 HTR1D HTR1D CACNA1S CACNA1S LOC110575026 LOC110575026 PRKCG PRKCG PTGS2 PTGS2 ITPR3 ITPR3 PLCB3 PLCB3 GNB1 GNB1 TPH1 TPH1 HTR2C HTR2C GNAI2 GNAI2 GNG3 GNG3 PRKCB PRKCB PLCB4 PLCB4 LOC110578248 LOC110578248 MAPK1 MAPK1 HTR1F HTR1F GNAI1 GNAI1 CSDE1 CSDE1 GNAI3 GNAI3 HTR2B HTR2B KRAS KRAS ITPR2 ITPR2 CACNA1C CACNA1C GNB3 GNB3 CACNA1B CACNA1B PTGS1 PTGS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASGTPase NRas. (189 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (100 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (881 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (118 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
DDCaromatic-L-amino-acid decarboxylase. (480 aa)
KCNJ3LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 1. (501 aa)
GABRB1Gamma-aminobutyric acid receptor subunit beta-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
HTR75-hydroxytryptamine receptor 7 isoform X1; Belongs to the G-protein coupled receptor 1 family. (448 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
SLC18A2Synaptic vesicular amine transporter. (517 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (525 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
LOC1105857725-hydroxytryptamine receptor 5B. (370 aa)
PLA2G4EPhospholipase A2. (841 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ALOX15BLOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B. (677 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R-type. (699 aa)
LOC110584449Arachidonate 15-lipoxygenase. (663 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (443 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLA2G4BPhospholipase A2. (782 aa)
PLA2G4FPhospholipase A2. (860 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (404 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
LOC110582495LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (373 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type isoform X1. (663 aa)
HTR3CLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
LOC110584496LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, epidermal-type-like. (453 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LOC1105826135-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
LOC110582484LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC110582001LOW QUALITY PROTEIN: cytochrome P450 2K1-like; Belongs to the cytochrome P450 family. (511 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
APPAmyloid beta A4 protein isoform X1. (770 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (456 aa)
TPH2Tryptophan 5-hydroxylase 2 isoform X1. (497 aa)
TRPC1Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
ERASGTPase ERas. (233 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LOC110571781Cytochrome P450 2J2; Belongs to the cytochrome P450 family. (502 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
LOC110571954Cytochrome P450 2W1; Belongs to the cytochrome P450 family. (501 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
LOC110573035Amine oxidase. (411 aa)
PLA2G4APhospholipase A2. (733 aa)
MAOAAmine oxidase. (527 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (392 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
HTR1D5-hydroxytryptamine receptor 1D. (399 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
LOC110575026LOW QUALITY PROTEIN: cytochrome P450 4X1-like. (513 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
TPH1Tryptophan 5-hydroxylase 1. (444 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
LOC110578248LOW QUALITY PROTEIN: cytochrome P450 2D15; Belongs to the cytochrome P450 family. (491 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2334 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (600 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (34%) [HD]