STRINGSTRING
ITPR1 ITPR1 CACNA1D CACNA1D LOC110582495 LOC110582495 ALOX12 ALOX12 HTR3C HTR3C LOC110584496 LOC110584496 CASP3 CASP3 GNB5 GNB5 HTR1E HTR1E BRAF BRAF PLA2G4F PLA2G4F PRKACB PRKACB LOC110582613 LOC110582613 ADCY5 ADCY5 LOC110582484 LOC110582484 GNB4 GNB4 HRAS HRAS GNG5 GNG5 LOC110582001 LOC110582001 GNGT1 GNGT1 NRAS NRAS GNG11 GNG11 GNG10 GNG10 PLCB1 PLCB1 PTGS1 PTGS1 CACNA1B CACNA1B GNB3 GNB3 CACNA1C CACNA1C ITPR2 ITPR2 KRAS KRAS HTR2B HTR2B GNAI3 GNAI3 CSDE1 CSDE1 GNAI1 GNAI1 HTR1F HTR1F MAPK1 MAPK1 LOC110578248 LOC110578248 PLCB4 PLCB4 PRKCB PRKCB GNG3 GNG3 LOC110584449 LOC110584449 ALOX12B ALOX12B ALOX15B ALOX15B PLA2G4E PLA2G4E LOC110585772 LOC110585772 HTR2A HTR2A GNG13 GNG13 SLC18A1 SLC18A1 GABRB2 GABRB2 MAPK3 MAPK3 GNG2 GNG2 SLC18A2 SLC18A2 ALOX5 ALOX5 HTR7 HTR7 GABRB1 GABRB1 KCNJ3 KCNJ3 DDC DDC SLC6A4 SLC6A4 HTR1A HTR1A GNGT2 GNGT2 RAPGEF3 RAPGEF3 CACNA1A CACNA1A PRKACA PRKACA GNAO1 GNAO1 GNG7 GNG7 GNG14 GNG14 PLA2G4B PLA2G4B PLA2G4D PLA2G4D GNG4 GNG4 HTR3A HTR3A KCNJ5 KCNJ5 HTR3B HTR3B HTR1B HTR1B JMJD7 JMJD7 HTR4 HTR4 PLCB2 PLCB2 HTR5A HTR5A RAF1 RAF1 GNAI2 GNAI2 HTR2C HTR2C TPH1 TPH1 GNB1 GNB1 PLCB3 PLCB3 ITPR3 ITPR3 PTGS2 PTGS2 PRKCG PRKCG LOC110575026 LOC110575026 CACNA1S CACNA1S HTR1D HTR1D HTR6 HTR6 KCNJ9 KCNJ9 MAOA MAOA PLA2G4A PLA2G4A LOC110573035 LOC110573035 GABRB3 GABRB3 GNG12 GNG12 GNG8 GNG8 LOC110571954 LOC110571954 ARAF ARAF GNB2 GNB2 LOC110571781 LOC110571781 PRKCA PRKCA ERAS ERAS CACNA1F CACNA1F TRPC1 TRPC1 TPH2 TPH2 KCNJ6 KCNJ6 APP APP LOC110569839 LOC110569839 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
LOC110582495LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (373 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type isoform X1. (663 aa)
HTR3CLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
LOC110584496LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, epidermal-type-like. (453 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
PLA2G4FPhospholipase A2. (860 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LOC1105826135-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
LOC110582484LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC110582001LOW QUALITY PROTEIN: cytochrome P450 2K1-like; Belongs to the cytochrome P450 family. (511 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
NRASGTPase NRas. (189 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (600 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2334 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KRASGTPase KRas. (188 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110578248LOW QUALITY PROTEIN: cytochrome P450 2D15; Belongs to the cytochrome P450 family. (491 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC110584449Arachidonate 15-lipoxygenase. (663 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R-type. (699 aa)
ALOX15BLOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B. (677 aa)
PLA2G4EPhospholipase A2. (841 aa)
LOC1105857725-hydroxytryptamine receptor 5B. (370 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (525 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SLC18A2Synaptic vesicular amine transporter. (517 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
HTR75-hydroxytryptamine receptor 7 isoform X1; Belongs to the G-protein coupled receptor 1 family. (448 aa)
GABRB1Gamma-aminobutyric acid receptor subunit beta-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
KCNJ3LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 1. (501 aa)
DDCaromatic-L-amino-acid decarboxylase. (480 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (118 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (881 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (100 aa)
PLA2G4BPhospholipase A2. (782 aa)
PLA2G4DPhospholipase A2. (817 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (443 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (404 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
TPH1Tryptophan 5-hydroxylase 1. (444 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC110575026LOW QUALITY PROTEIN: cytochrome P450 4X1-like. (513 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
HTR1D5-hydroxytryptamine receptor 1D. (399 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (392 aa)
MAOAAmine oxidase. (527 aa)
PLA2G4APhospholipase A2. (733 aa)
LOC110573035Amine oxidase. (411 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC110571954Cytochrome P450 2W1; Belongs to the cytochrome P450 family. (501 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
LOC110571781Cytochrome P450 2J2; Belongs to the cytochrome P450 family. (502 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ERASGTPase ERas. (233 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
TRPC1Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
TPH2Tryptophan 5-hydroxylase 2 isoform X1. (497 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (456 aa)
APPAmyloid beta A4 protein isoform X1. (770 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (28%) [HD]