STRINGSTRING
INSR INSR ACACA ACACA CRK CRK PRKAG1 PRKAG1 INPPL1 INPPL1 ACACB ACACB PHKB PHKB TRIP10 TRIP10 PTPRS PTPRS PRKACA PRKACA RPS6KB1 RPS6KB1 SHC2 SHC2 INPP5A INPP5A PRKAG3 PRKAG3 MKNK2 MKNK2 CRYBB3 CRYBB3 PRKAB1 PRKAB1 RHEBL1 RHEBL1 MAP2K2 MAP2K2 LOC110592076 LOC110592076 PRKCI PRKCI RRAD RRAD FLOT2 FLOT2 GCK GCK KIAA1671 KIAA1671 RHOQ RHOQ LOC110592210 LOC110592210 AKT2 AKT2 G6PC2 G6PC2 LOC110592156 LOC110592156 LOC110591392 LOC110591392 TBCA TBCA ALKBH4 ALKBH4 LOC110591391 LOC110591391 PIK3R1 PIK3R1 BUD23 BUD23 SORBS1 SORBS1 BMT2 BMT2 SOCS4 SOCS4 SOS2 SOS2 PYGL PYGL HK3 HK3 PYGB PYGB MAPK3 MAPK3 SH2B2 SH2B2 PHKG1 PHKG1 PPP1CC PPP1CC MAPK8 MAPK8 HK1 HK1 PHKG2 PHKG2 HKDC1 HKDC1 PPP1R3C PPP1R3C PPP1R3A PPP1R3A HK2 HK2 SOS1 SOS1 PPP1R3G PPP1R3G LIPE LIPE SORBS3 SORBS3 TSC2 TSC2 SOCS1 SOCS1 CBL CBL PDPK1 PDPK1 PPP1CB PPP1CB PPP1R3E PPP1R3E FLOT1 FLOT1 LOC110586587 LOC110586587 CALML5 CALML5 SLC2A4 SLC2A4 TMEM145 TMEM145 PRKAA1 PRKAA1 CALML4 CALML4 MYO9A MYO9A IRS2 IRS2 EIF4E1B EIF4E1B PCK2 PCK2 RAF1 RAF1 RHEB RHEB SREBF1 SREBF1 SHC3 SHC3 SORBS2 SORBS2 PPP1R3B PPP1R3B MAP2K1 MAP2K1 SHC4 SHC4 CEP152 CEP152 RAPGEF1 RAPGEF1 PRKAG2 PRKAG2 CRYGN CRYGN EIF4E2 EIF4E2 BRAF BRAF PRKACB PRKACB GSK3B GSK3B CBLB CBLB PIK3CA PIK3CA LOC110582265 LOC110582265 HRAS HRAS NRAS NRAS REM1 REM1 TSC1 TSC1 GEM GEM GYS2 GYS2 KRAS KRAS CSDE1 CSDE1 MAPK9 MAPK9 SOCS2 SOCS2 MAPK1 MAPK1 PRKAB2 PRKAB2 CRKL CRKL PTPN1 PTPN1 ELK3 ELK3 SREBF2 SREBF2 INS INS BAD BAD PRKAR2A PRKAR2A PPP1R14B PPP1R14B PIK3CD PIK3CD MKNK1 MKNK1 PIK3R3 PIK3R3 PDE3B PDE3B PTPRF PTPRF MTOR MTOR MYO9B MYO9B RPS6KB2 RPS6KB2 PPP1CA PPP1CA PYGM PYGM PRKCZ PRKCZ CALML6 CALML6 LOC110573816 LOC110573816 PRKAA2 PRKAA2 PHKA2 PHKA2 PKLR PKLR PTPRD PTPRD SHC1 SHC1 PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 IRS1 IRS1 PRKAR2B PRKAR2B AKT3 AKT3 G6PC G6PC RPS6 RPS6 GRB2 GRB2 RPTOR RPTOR G6PC3 G6PC3 IKBKB IKBKB AKT1 AKT1 GYS1 GYS1 FASN FASN EXOC7 EXOC7 ELK1 ELK1 SOCS3 SOCS3 LOC110572425 LOC110572425 PPARGC1A PPARGC1A ARAF ARAF EIF4E EIF4E PRKAR1B PRKAR1B LOC110571849 LOC110571849 PHKA1 PHKA1 CALM1 CALM1 LOC110570537 LOC110570537 PIK3CB PIK3CB PPP1R3F PPP1R3F EFCAB13 EFCAB13 ERAS ERAS FBP1 FBP1 IRS4 IRS4 EFCAB3 EFCAB3 PRKAR1A PRKAR1A FOXO1 FOXO1 FBP2 FBP2 PCK1 PCK1 PPP1R3D PPP1R3D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRTyrosine-protein kinase receptor. (1368 aa)
ACACALOW QUALITY PROTEIN: acetyl-CoA carboxylase 1. (2346 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1264 aa)
ACACBacetyl-CoA carboxylase 2. (2456 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1086 aa)
TRIP10Cdc42-interacting protein 4 isoform X3. (601 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1874 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SHC2SHC-transforming protein 2. (551 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase. (293 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1. (586 aa)
CRYBB3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (211 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
RHEBL1GTPase RhebL1. (183 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC110592076Calmodulin-like; Belongs to the calmodulin family. (210 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
GCKPhosphotransferase. (465 aa)
KIAA1671LOW QUALITY PROTEIN: uncharacterized protein KIAA1671 homolog. (1827 aa)
RHOQRho-related GTP-binding protein RhoQ. (205 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (129 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (302 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
BUD23Probable 18S rRNA (Guanine-N(7))-methyltransferase isoform X1. (282 aa)
SORBS1Sorbin and SH3 domain-containing protein 1. (1282 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
HK3Hexokinase-3. (924 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SH2B2SH2B adapter protein 2. (937 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily. (390 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HK1Hexokinase-1. (917 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Belongs to the protein kinase superfamily. (406 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (917 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1121 aa)
HK2Hexokinase-2. (917 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (351 aa)
LIPEHormone-sensitive lipase isoform X1. (806 aa)
SORBS3Vinexin isoform X1. (675 aa)
TSC2Tuberin isoform X1. (1789 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (277 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CALML5Calmodulin-like protein 5. (149 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
TMEM145Transmembrane protein 145. (508 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
MYO9AUnconventional myosin-IXa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2558 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RHEBGTP-binding protein Rheb. (184 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X3. (1180 aa)
SHC3SHC-transforming protein 3. (469 aa)
SORBS2Sorbin and SH3 domain-containing protein 2 isoform X1. (1227 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1025 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
CRYGNGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (183 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC11058226540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
TSC1Hamartin. (1168 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
CRKLCrk-like protein. (303 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (453 aa)
ELK3ETS domain-containing protein Elk-3 isoform X1. (402 aa)
SREBF2Sterol regulatory element-binding protein 2. (1131 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (401 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (418 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PDE3BPhosphodiesterase. (1167 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1917 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
MYO9BUnconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2154 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
CALML6Calmodulin-like protein 6. (232 aa)
LOC110573816Receptor-type tyrosine-protein phosphatase S-like. (443 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1113 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (573 aa)
PTPRDReceptor-type tyrosine-protein phosphatase delta. (1584 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (387 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
FASNFatty acid synthase. (2519 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (435 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit. (377 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1053 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
LOC110570537cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X2. (328 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (406 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium-binding domain-containing protein 13. (906 aa)
ERASGTPase ERas. (233 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
IRS4Insulin receptor substrate 4. (1244 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3 isoform X1. (646 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1. (381 aa)
FOXO1Forkhead box protein O1. (663 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (622 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (26%) [HD]