STRINGSTRING
VAMP2 VAMP2 CACNA1D CACNA1D KCNMB2 KCNMB2 PLCB2 PLCB2 ADCY4 ADCY4 CHRM3 CHRM3 RYR2 RYR2 FXYD2 FXYD2 GNA11 GNA11 ATF2 ATF2 PRKACA PRKACA FAP FAP CREB3L3 CREB3L3 ADCY1 ADCY1 ATP1B2 ATP1B2 CAMK2A CAMK2A ADCY3 ADCY3 LOC110585337 LOC110585337 ARSI ARSI ATF6B ATF6B KCNMA1 KCNMA1 PTRHD1 PTRHD1 CAMK2G CAMK2G KCNMB1 KCNMB1 ADCY9 ADCY9 STX1A STX1A RAB3C RAB3C KCNN2 KCNN2 ADCY2 ADCY2 SLC2A2 SLC2A2 FFAR1 FFAR1 TNIK TNIK RAPGEF4 RAPGEF4 CREB1 CREB1 GCG GCG GCK GCK CAMK2B CAMK2B GIP GIP ADCY7 ADCY7 ADCY6 ADCY6 GNAS GNAS LOC110569839 LOC110569839 KCNMB4 KCNMB4 CCK CCK CACNA1F CACNA1F PDX1 PDX1 PRKCA PRKCA CCKAR CCKAR ATP1B3 ATP1B3 TRPM4 TRPM4 LOC110573336 LOC110573336 ATP1A4 ATP1A4 CREB3L4 CREB3L4 KCNN4 KCNN4 ATP1B1 ATP1B1 KCNN1 KCNN1 KCNN3 KCNN3 KCNU1 KCNU1 CACNA1S CACNA1S PRKCG PRKCG RAB3B RAB3B SLC2A1 SLC2A1 RAB3A RAB3A CREB3L1 CREB3L1 PLCB3 PLCB3 GPR119 GPR119 ABCC8 ABCC8 GLP1R GLP1R ADCYAP1 ADCYAP1 CAMK2D CAMK2D INS INS KCNJ11 KCNJ11 ATP1B4 ATP1B4 RIMS2 RIMS2 PRKCB PRKCB PLCB4 PLCB4 SNAP25 SNAP25 ATF4 ATF4 ADCYAP1R1 ADCYAP1R1 PCLO PCLO CREB5 CREB5 ATP1A1 ATP1A1 CACNA1C CACNA1C ADCY8 ADCY8 LOC110579709 LOC110579709 PLCB1 PLCB1 CREB3 CREB3 ATP1A3 ATP1A3 ADCY5 ADCY5 PRKACB PRKACB CREB3L2 CREB3L2 VAMP1 VAMP1 KCNMB3 KCNMB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAMP2Vesicle-associated membrane protein 2. (71 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
RYR2Ryanodine receptor 2. (5000 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
FAPLOW QUALITY PROTEIN: prolyl endopeptidase FAP; Belongs to the peptidase S9B family. (760 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
LOC110585337Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ARSIArylsulfatase I. (575 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X2. (1262 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
STX1Asyntaxin-1A; Belongs to the syntaxin family. (258 aa)
RAB3CRas-related protein Rab-3C. (219 aa)
KCNN2Small conductance calcium-activated potassium channel protein 2. (845 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
TNIKTRAF2 and NCK-interacting protein kinase. (1360 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
GCGGlucagon isoform X1. (180 aa)
GCKPhosphotransferase. (465 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
GIPGastric inhibitory polypeptide. (145 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
CCKCholecystokinin. (116 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (428 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3. (350 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1211 aa)
LOC110573336Sodium/potassium-transporting ATPase subunit alpha. (1073 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
KCNN4Intermediate conductance calcium-activated potassium channel protein 4. (427 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
KCNN1Small conductance calcium-activated potassium channel protein 1. (547 aa)
KCNN3Small conductance calcium-activated potassium channel protein 3. (705 aa)
KCNU1LOW QUALITY PROTEIN: potassium channel subfamily U member 1. (881 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
RAB3BRas-related protein Rab-3B. (219 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GPR119Glucose-dependent insulinotropic receptor; Belongs to the G-protein coupled receptor 1 family. (334 aa)
ABCC8ATP-binding cassette sub-family C member 8 isoform X1. (1602 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (390 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X1. (1607 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3; Belongs to the G-protein coupled receptor 2 family. (497 aa)
PCLOLOW QUALITY PROTEIN: protein piccolo. (4914 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
LOC110579709Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha-3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1121 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
VAMP1Vesicle-associated membrane protein 1 isoform X1. (218 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (185 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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