STRINGSTRING
PRKCD PRKCD GNAS GNAS LOC110569839 LOC110569839 KCNJ6 KCNJ6 ERAS ERAS TFF1 TFF1 FOS FOS PIK3CB PIK3CB CALM1 CALM1 PGR PGR HSP90AA1 HSP90AA1 GPER1 GPER1 LOC110572425 LOC110572425 AKT1 AKT1 KRT38 KRT38 LOC110573247 LOC110573247 KRT9 KRT9 LOC110573280 LOC110573280 LOC110573279 LOC110573279 LOC110573324 LOC110573324 KRT15 KRT15 KRT19 KRT19 CREB3L4 CREB3L4 GRB2 GRB2 AKT3 AKT3 LOC110573249 LOC110573249 LOC110573277 LOC110573277 LOC110573283 LOC110573283 LOC110573323 LOC110573323 KCNJ9 KCNJ9 PIK3R2 PIK3R2 SHC1 SHC1 LOC110573248 LOC110573248 LOC110573282 LOC110573282 LOC110573327 LOC110573327 JUN JUN CALML6 CALML6 ITPR3 ITPR3 FKBP5 FKBP5 CREB3L1 CREB3L1 PLCB3 PLCB3 PIK3R3 PIK3R3 PIK3CD PIK3CD BCL2 BCL2 KRT18 KRT18 GNAI2 GNAI2 HSP90B1 HSP90B1 EBAG9 EBAG9 NCOA2 NCOA2 SP1 SP1 PLCB4 PLCB4 MMP9 MMP9 ATF4 ATF4 SRC SRC NCOA3 NCOA3 MAPK1 MAPK1 GNAI1 GNAI1 CREB5 CREB5 CSDE1 CSDE1 GNAI3 GNAI3 KRAS KRAS ITPR2 ITPR2 ADCY8 ADCY8 PLCB1 PLCB1 CREB3 CREB3 GABBR2 GABBR2 NRAS NRAS HSP90AB1 HSP90AB1 HRAS HRAS PIK3CA PIK3CA ADCY5 ADCY5 PRKACB PRKACB IFITM10 IFITM10 CREB3L2 CREB3L2 FKBP4 FKBP4 NOS3 NOS3 ESR1 ESR1 GRM1 GRM1 CEP152 CEP152 SHC4 SHC4 MAP2K1 MAP2K1 SHC3 SHC3 LOC110584341 LOC110584341 ITPR1 ITPR1 RAF1 RAF1 LOC110582885 LOC110582885 PLCB2 PLCB2 CCDC170 CCDC170 ADCY4 ADCY4 OPRM1 OPRM1 CALML4 CALML4 KCNJ5 KCNJ5 CALML5 CALML5 LOC110586587 LOC110586587 GABBR1 GABBR1 LOC110586857 LOC110586857 ADCY3 ADCY3 MMP20 MMP20 HSPA8 HSPA8 HSPA1A HSPA1A SOS1 SOS1 TGFA TGFA POMC POMC ATF6B ATF6B PTRHD1 PTRHD1 NCOA1 NCOA1 ADCY9 ADCY9 HSPA6 HSPA6 MAPK3 MAPK3 SOS2 SOS2 LOC110590588 LOC110590588 HBEGF HBEGF PIK3R1 PIK3R1 ADCY2 ADCY2 HSPA2 HSPA2 LOC110592156 LOC110592156 ESR2 ESR2 CREB1 CREB1 AKT2 AKT2 KCNJ3 KCNJ3 LOC110592210 LOC110592210 RARA RARA KRT10 KRT10 EGFR EGFR KRT27 KRT27 KRT25 KRT25 KRT28 KRT28 KRT26 KRT26 KRT12 KRT12 KRT40 KRT40 KRT39 KRT39 MMP2 MMP2 ADCY7 ADCY7 MAP2K2 MAP2K2 ADCY6 ADCY6 ADCY1 ADCY1 CREB3L3 CREB3L3 SHC2 SHC2 PRKACA PRKACA KRT23 KRT23 KRT24 KRT24 GNAO1 GNAO1 ATF2 ATF2 KRT20 KRT20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (456 aa)
ERASGTPase ERas. (233 aa)
TFF1Trefoil factor 1. (88 aa)
FOSProto-oncogene c-Fos. (380 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PGRProgesterone receptor isoform X1. (930 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRT38Keratin, type I cuticular Ha8; Belongs to the intermediate filament family. (457 aa)
LOC110573247Keratin, type I cytoskeletal 16; Belongs to the intermediate filament family. (465 aa)
KRT9LOW QUALITY PROTEIN: keratin, type I cytoskeletal 9; Belongs to the intermediate filament family. (564 aa)
LOC110573280Keratin, type I cuticular Ha8-like; Belongs to the intermediate filament family. (440 aa)
LOC110573279Keratin, type I cuticular Ha2-like; Belongs to the intermediate filament family. (441 aa)
LOC110573324Keratin, type I cytoskeletal 14; Belongs to the intermediate filament family. (470 aa)
KRT15Keratin, type I cytoskeletal 15; Belongs to the intermediate filament family. (465 aa)
KRT19Keratin, type I cytoskeletal 19; Belongs to the intermediate filament family. (407 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC110573249Keratin, type I cuticular Ha5; Belongs to the intermediate filament family. (455 aa)
LOC110573277LOW QUALITY PROTEIN: keratin, type I cytoskeletal 42-like; Belongs to the intermediate filament family. (462 aa)
LOC110573283Keratin, type I cuticular Ha1-like; Belongs to the intermediate filament family. (341 aa)
LOC110573323Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (436 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (392 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
LOC110573248Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (467 aa)
LOC110573282Keratin, type I cuticular Ha8-like; Belongs to the intermediate filament family. (437 aa)
LOC110573327Keratin, type I cytoskeletal 13; Belongs to the intermediate filament family. (445 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
CALML6Calmodulin-like protein 6. (232 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
FKBP5Peptidylprolyl isomerase. (456 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (315 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
HSP90B1LOW QUALITY PROTEIN: endoplasmin. (804 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells isoform X1. (308 aa)
NCOA2Nuclear receptor coactivator. (1459 aa)
SP1Transcription factor Sp1. (786 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
SRCTyrosine-protein kinase. (536 aa)
NCOA3Nuclear receptor coactivator. (1402 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (840 aa)
NRASGTPase NRas. (189 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
IFITM10Interferon-induced transmembrane protein 10. (176 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1190 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC3SHC-transforming protein 3. (469 aa)
LOC110584341Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (430 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
LOC110582885Cathepsin E-like. (174 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
CCDC170Coiled-coil domain-containing protein 170. (716 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
OPRM1Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (419 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (963 aa)
LOC110586857Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (646 aa)
HSPA1AHeat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (641 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
TGFAProtransforming growth factor alpha. (160 aa)
POMCPro-opiomelanocortin. (265 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
LOC110590588Coiled-coil domain-containing protein 170-like. (607 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
ESR2Estrogen receptor beta isoform X1. (530 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
KCNJ3LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 1. (501 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
KRT10Keratin, type I cytoskeletal 10 isoform X1; Belongs to the intermediate filament family. (571 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
KRT27Keratin, type I cytoskeletal 27; Belongs to the intermediate filament family. (450 aa)
KRT25LOW QUALITY PROTEIN: keratin, type I cytoskeletal 25; Belongs to the intermediate filament family. (450 aa)
KRT28Keratin, type I cytoskeletal 28; Belongs to the intermediate filament family. (464 aa)
KRT26Keratin, type I cytoskeletal 26; Belongs to the intermediate filament family. (464 aa)
KRT12Keratin, type I cytoskeletal 12; Belongs to the intermediate filament family. (489 aa)
KRT40Keratin, type I cytoskeletal 40; Belongs to the intermediate filament family. (430 aa)
KRT39Keratin, type I cytoskeletal 39; Belongs to the intermediate filament family. (484 aa)
MMP272 kDa type IV collagenase. (661 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
SHC2SHC-transforming protein 2. (551 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
KRT23Keratin, type I cytoskeletal 23; Belongs to the intermediate filament family. (420 aa)
KRT24Keratin, type I cytoskeletal 24; Belongs to the intermediate filament family. (517 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
KRT20Keratin, type I cytoskeletal 20; Belongs to the intermediate filament family. (428 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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