STRINGSTRING
PPARGC1A PPARGC1A PDHA2 PDHA2 PPP3CA PPP3CA SIK1 SIK1 LOC110571842 LOC110571842 PHKA1 PHKA1 CALM1 CALM1 PFKL PFKL FBP1 FBP1 LOC110569775 LOC110569775 FOXO1 FOXO1 LOC110569839 LOC110569839 FBP2 FBP2 GNAS GNAS ACACA ACACA PRKAG1 PRKAG1 PFKM PFKM ACACB ACACB PHKB PHKB ATF2 ATF2 PRKACA PRKACA PRKAG3 PRKAG3 PCK1 PCK1 FAP FAP CREB3L3 CREB3L3 PRKAB1 PRKAB1 PGAM2 PGAM2 CAMK2B CAMK2B GCK GCK LOC110592210 LOC110592210 GCG GCG AKT2 AKT2 CREB1 CREB1 G6PC2 G6PC2 LOC110592156 LOC110592156 PPP4R3B PPP4R3B TNIK TNIK PPP4C PPP4C SLC2A2 SLC2A2 ADCY2 ADCY2 PPP3CB PPP3CB PGAM1 PGAM1 PFKFB1 PFKFB1 SIRT1 SIRT1 PPP3R1 PPP3R1 LOC110590435 LOC110590435 PYGL PYGL PYGB PYGB PHKG1 PHKG1 PHKG2 PHKG2 CAMK2G CAMK2G ARSI ARSI PARP8 PARP8 PPP3CC PPP3CC CREBBP CREBBP SIK2 SIK2 LOC110588028 LOC110588028 PDHB PDHB CAMK2A CAMK2A LOC110586587 LOC110586587 CALML5 CALML5 PRKAA1 PRKAA1 CALML4 CALML4 PLCB2 PLCB2 PCK2 PCK2 ITPR1 ITPR1 PARP6 PARP6 PKM PKM LOC110583041 LOC110583041 PRKAG2 PRKAG2 CREB3L2 CREB3L2 PRKACB PRKACB LDHB LDHB PPP3R2 PPP3R2 CREB3 CREB3 PLCB1 PLCB1 PFKP PFKP ITPR2 ITPR2 GYS2 GYS2 CREB5 CREB5 ATF4 ATF4 PLCB4 PLCB4 EP300 EP300 PRKAB2 PRKAB2 CPT1B CPT1B CPT1A CPT1A PPARA PPARA LDHC LDHC CAMK2D CAMK2D PDE3B PDE3B LDHA LDHA PDHA1 PDHA1 PYGM PYGM PLCB3 PLCB3 CREB3L1 CREB3L1 ITPR3 ITPR3 CALML6 CALML6 SLC2A1 SLC2A1 PRKAA2 PRKAA2 PHKA2 PHKA2 CPT1C CPT1C AKT3 AKT3 G6PC G6PC GCGR GCGR CRTC2 CRTC2 CREB3L4 CREB3L4 G6PC3 G6PC3 PRMT1 PRMT1 AKT1 AKT1 GYS1 GYS1 LOC110572425 LOC110572425 PPP4R3A PPP4R3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
PPP3CASerine/threonine-protein phosphatase. (526 aa)
SIK1Serine/threonine-protein kinase SIK1. (777 aa)
LOC110571842L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1053 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
LOC110569775Serine/threonine-protein phosphatase 4 regulatory subunit 3B-like. (728 aa)
FOXO1Forkhead box protein O1. (663 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
ACACALOW QUALITY PROTEIN: acetyl-CoA carboxylase 1. (2346 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (853 aa)
ACACBacetyl-CoA carboxylase 2. (2456 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1086 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (622 aa)
FAPLOW QUALITY PROTEIN: prolyl endopeptidase FAP; Belongs to the peptidase S9B family. (760 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
GCKPhosphotransferase. (465 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
GCGGlucagon isoform X1. (180 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
PPP4R3BSerine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1. (817 aa)
TNIKTRAF2 and NCK-interacting protein kinase. (1360 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1. (471 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (746 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
LOC110590435L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (274 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily. (390 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Belongs to the protein kinase superfamily. (406 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
ARSIArylsulfatase I. (575 aa)
PARP8Poly [ADP-ribose] polymerase. (854 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
SIK2Serine/threonine-protein kinase SIK2. (914 aa)
LOC110588028L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (344 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CALML5Calmodulin-like protein 5. (149 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
LOC110583041L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (375 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (790 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
PDE3BPhosphodiesterase. (1167 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
CALML6Calmodulin-like protein 6. (232 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1113 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (456 aa)
CRTC2CREB-regulated transcription coactivator 2. (695 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
PPP4R3ASerine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1. (833 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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