STRINGSTRING
PLCB3 PLCB3 MAP2K7 MAP2K7 GNG14 GNG14 GNG7 GNG7 ATF2 ATF2 GNAO1 GNAO1 NOS2 NOS2 PRKACA PRKACA SHC2 SHC2 CREB3L3 CREB3L3 ADCY1 ADCY1 RLN3 RLN3 GNA15 GNA15 ADCY6 ADCY6 MAP2K2 MAP2K2 ADCY7 ADCY7 MMP2 MMP2 ARRB1 ARRB1 GNGT2 GNGT2 COL1A1 COL1A1 EGFR EGFR AKT2 AKT2 CREB1 CREB1 COL3A1 COL3A1 ADCY2 ADCY2 LOC110591392 LOC110591392 LOC110591391 LOC110591391 PIK3R1 PIK3R1 GNG2 GNG2 SOS2 SOS2 TGFB1 TGFB1 MAPK3 MAPK3 MAPK8 MAPK8 NOS1 NOS1 ADCY9 ADCY9 PTRHD1 PTRHD1 EDNRB EDNRB ATF6B ATF6B SOS1 SOS1 RXFP1 RXFP1 FBXO21 FBXO21 MMP20 MMP20 GNG13 GNG13 COL4A1 COL4A1 COL4A2 COL4A2 NFKBIA NFKBIA ADCY3 ADCY3 EDN1 EDN1 MAP2K4 MAP2K4 ARRB2 ARRB2 LOC110586384 LOC110586384 MMP13 MMP13 LOC110586222 LOC110586222 GNG4 GNG4 ADCY4 ADCY4 LOC110583310 LOC110583310 PLCB2 PLCB2 RXFP3 RXFP3 RAF1 RAF1 RLN1 RLN1 SHC3 SHC3 VEGFC VEGFC GNB5 GNB5 MAP2K1 MAP2K1 TGFBR1 TGFBR1 SHC4 SHC4 CEP152 CEP152 VEGFA VEGFA NOS3 NOS3 CREB3L2 CREB3L2 PRKACB PRKACB ADCY5 ADCY5 GNB4 GNB4 PIK3CA PIK3CA HRAS HRAS GNG5 GNG5 GNGT1 GNGT1 NRAS NRAS GNG11 GNG11 CREB3 CREB3 GNG10 GNG10 PLCB1 PLCB1 ADCY8 ADCY8 GNB3 GNB3 KRAS KRAS GNAI3 GNAI3 CSDE1 CSDE1 MAPK9 MAPK9 CREB5 CREB5 GNAI1 GNAI1 COL1A2 COL1A2 MAPK1 MAPK1 MAPK11 MAPK11 SRC SRC ATF4 ATF4 MMP9 MMP9 PLCB4 PLCB4 MAPK12 MAPK12 SMAD2 SMAD2 GNG3 GNG3 GNAI2 GNAI2 PIK3CD PIK3CD PIK3R3 PIK3R3 GNB1 GNB1 VEGFB VEGFB RELA RELA CREB3L1 CREB3L1 MAPK14 MAPK14 PRKCZ PRKCZ MAPK13 MAPK13 INSL3 INSL3 COL4A4 COL4A4 JUN JUN SHC1 SHC1 PIK3R2 PIK3R2 MFF MFF COL4A3 COL4A3 AKT3 AKT3 GRB2 GRB2 CREB3L4 CREB3L4 NFKB1 NFKB1 GNG12 GNG12 AKT1 AKT1 GNG8 GNG8 VEGFD VEGFD ARR3 ARR3 TGFBR2 TGFBR2 GNB2 GNB2 WDR78 WDR78 INSL5 INSL5 PIK3CB PIK3CB FOS FOS COL4A6 COL4A6 PRKCA PRKCA RXFP2 RXFP2 ERAS ERAS COL4A5 COL4A5 LOC110569839 LOC110569839 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (440 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (100 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SHC2SHC-transforming protein 2. (551 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
RLN3Relaxin-3. (159 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MMP272 kDa type IV collagenase. (661 aa)
ARRB1Beta-arrestin-1. (418 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (118 aa)
COL1A1Collagen alpha-1(I) chain. (1460 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NOS1Nitric oxide synthase, brain isoform X1. (1467 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
EDNRBLOW QUALITY PROTEIN: endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (540 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
RXFP1Relaxin receptor 1. (758 aa)
FBXO21F-box only protein 21 isoform X1. (627 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
COL4A1Collagen alpha-1(IV) chain. (1669 aa)
COL4A2Collagen alpha-2(IV) chain. (1712 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
EDN1Endothelin-1. (202 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
ARRB2Beta-arrestin-2. (409 aa)
LOC110586384LOW QUALITY PROTEIN: interstitial collagenase-like. (464 aa)
MMP13Collagenase 3. (470 aa)
LOC110586222Interstitial collagenase-like. (466 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
RXFP3Relaxin-3 receptor 1. (495 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RLN1Prorelaxin H1 isoform X1. (186 aa)
SHC3SHC-transforming protein 3. (469 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
NRASGTPase NRas. (189 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
KRASGTPase KRas. (188 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SRCTyrosine-protein kinase. (536 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
RELATranscription factor p65. (531 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
INSL3Insulin-like 3. (130 aa)
COL4A4Collagen alpha-4(IV) chain. (1688 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
MFFMitochondrial fission factor isoform X1. (302 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (357 aa)
ARR3arrestin-C. (392 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
WDR78LOW QUALITY PROTEIN: WD repeat-containing protein 78. (786 aa)
INSL5LOW QUALITY PROTEIN: insulin-like peptide INSL5. (133 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
COL4A6Collagen alpha-6(IV) chain. (1566 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
RXFP2Relaxin receptor 2. (735 aa)
ERASGTPase ERas. (233 aa)
COL4A5Collagen alpha-5(IV) chain isoform X1. (1691 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (32%) [HD]