STRINGSTRING
PTH1R PTH1R GNAS GNAS LOC110569839 LOC110569839 LOC110569858 LOC110569858 NACA2 NACA2 GNA13 GNA13 PRKCA PRKCA SLC9A3R1 SLC9A3R1 FOS FOS PDE4B PDE4B ARR3 ARR3 SLC34A2 SLC34A2 AKAP13 AKAP13 ARAF ARAF GNA12 GNA12 FGFR1 FGFR1 MEF2A MEF2A CREB3L4 CREB3L4 BGLAP BGLAP ARHGEF11 ARHGEF11 JUND JUND SOST SOST MEF2D MEF2D PRKCG PRKCG RXRB RXRB CDKN1A CDKN1A ITPR3 ITPR3 CREB3L1 CREB3L1 PLCB3 PLCB3 PDE4C PDE4C LRP5 LRP5 BCL2 BCL2 LRP5L LRP5L GNAI2 GNAI2 PTH PTH NACA NACA LOC110577862 LOC110577862 LOC110577921 LOC110577921 MMP16 MMP16 SP1 SP1 PRKCB PRKCB PLCB4 PLCB4 ATF4 ATF4 MMP24 MMP24 MAPK1 MAPK1 GNAI1 GNAI1 CREB5 CREB5 GNAI3 GNAI3 ITPR2 ITPR2 PTHLH PTHLH ADCY8 ADCY8 SLC34A3 SLC34A3 LOC110579709 LOC110579709 PLCB1 PLCB1 CREB3 CREB3 MAFB MAFB RXRA RXRA GCM1 GCM1 ARHGEF1 ARHGEF1 LRP6 LRP6 FGF23 FGF23 ADCY5 ADCY5 PRKACB PRKACB BRAF BRAF CREB3L2 CREB3L2 TRPV5 TRPV5 RUNX2 RUNX2 CASR CASR ITPR1 ITPR1 RAF1 RAF1 PLCB2 PLCB2 MMP14 MMP14 ADCY4 ADCY4 LOC110583493 LOC110583493 MMP13 MMP13 GATA3 GATA3 ARRB2 ARRB2 PLD2 PLD2 MMP17 MMP17 ADCY3 ADCY3 MMP25 MMP25 SLC34A1 SLC34A1 MEF2C MEF2C ATF6B ATF6B GCM2 GCM2 PTRHD1 PTRHD1 ADCY9 ADCY9 RXRG RXRG TNFSF11 TNFSF11 MAPK3 MAPK3 HBEGF HBEGF PDE4D PDE4D ADCY2 ADCY2 PLD1 PLD1 CREB1 CREB1 EGR1 EGR1 EGFR EGFR MMP15 MMP15 NR4A2 NR4A2 ARRB1 ARRB1 ADCY7 ADCY7 ADCY6 ADCY6 PDE4A PDE4A ADCY1 ADCY1 CREB3L3 CREB3L3 PRKACA PRKACA ATF2 ATF2 VDR VDR GNA11 GNA11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Belongs to the G-protein coupled receptor 2 family. (589 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
LOC1105698581,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (514 aa)
NACA2LOW QUALITY PROTEIN: nascent polypeptide-associated complex subunit alpha-2. (216 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1. (280 aa)
FOSProto-oncogene c-Fos. (380 aa)
PDE4BPhosphodiesterase. (737 aa)
ARR3arrestin-C. (392 aa)
SLC34A2Sodium-dependent phosphate transport protein 2B. (693 aa)
AKAP13A-kinase anchor protein 13. (2819 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
MEF2ALOW QUALITY PROTEIN: myocyte-specific enhancer factor 2A. (486 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11 isoform X5. (1534 aa)
JUNDTranscription factor jun-D. (347 aa)
SOSTSclerostin. (213 aa)
MEF2DMyocyte-specific enhancer factor 2D isoform X1. (515 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
RXRBLOW QUALITY PROTEIN: retinoic acid receptor RXR-beta. (532 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PDE4CPhosphodiesterase. (724 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (979 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
LRP5LLOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein. (453 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
NACANascent polypeptide-associated complex subunit alpha. (215 aa)
LOC11057786225-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
LOC110577921Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (106 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
SP1Transcription factor Sp1. (786 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MMP24Matrix metalloproteinase-24. (578 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PTHLHParathyroid hormone-related protein. (177 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
SLC34A3Sodium-dependent phosphate transport protein 2C. (289 aa)
LOC110579709Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
MAFBTranscription factor MafB. (323 aa)
RXRARetinoic acid receptor RXR-alpha. (413 aa)
GCM1Chorion-specific transcription factor GCMa. (435 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (974 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (522 aa)
CASRExtracellular calcium-sensing receptor isoform X1. (1084 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
LOC110583493Sodium-dependent phosphate transport protein 2C-like. (311 aa)
MMP13Collagenase 3. (470 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
ARRB2Beta-arrestin-2. (409 aa)
PLD2Phospholipase. (933 aa)
MMP17Matrix metalloproteinase-17. (595 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
MMP25Matrix metalloproteinase-25. (559 aa)
SLC34A1Sodium-dependent phosphate transport protein 2A. (639 aa)
MEF2CMyocyte-specific enhancer factor 2C. (463 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
GCM2Chorion-specific transcription factor GCMb. (589 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
PDE4DPhosphodiesterase. (811 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PLD1Phospholipase. (1040 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
MMP15Matrix metalloproteinase-15. (673 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ARRB1Beta-arrestin-1. (418 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
PDE4APhosphodiesterase. (871 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
VDRVitamin D3 receptor. (427 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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