STRINGSTRING
IKBKB IKBKB G6PC3 G6PC3 MLX MLX SLC27A3 SLC27A3 CREB3L4 CREB3L4 CRTC2 CRTC2 RPS6KA3 RPS6KA3 NR1H2 NR1H2 G6PC G6PC AKT3 AKT3 IRS1 IRS1 SLC27A1 SLC27A1 PIK3R2 PIK3R2 STAT3 STAT3 PRKAA2 PRKAA2 RPS6KA1 RPS6KA1 SLC2A1 SLC2A1 LOC110575329 LOC110575329 PRKCZ PRKCZ CREB3L1 CREB3L1 RELA RELA PYGM PYGM PPP1CA PPP1CA RPS6KB2 RPS6KB2 MTOR MTOR PTPRF PTPRF PIK3R3 PIK3R3 PIK3CD PIK3CD NR1H3 NR1H3 INS INS PPARA PPARA CPT1A CPT1A PTPN1 PTPN1 CPT1B CPT1B PRKAB2 PRKAB2 PRKCB PRKCB TRIB3 TRIB3 CD36 CD36 IL6 IL6 CREB5 CREB5 MAPK9 MAPK9 GFPT2 GFPT2 TNFRSF1A TNFRSF1A GYS2 GYS2 CREB3 CREB3 PIK3CA PIK3CA GSK3B GSK3B CREB3L2 CREB3L2 PRKAG2 PRKAG2 NOS3 NOS3 RPS6KA2 RPS6KA2 RPS6KA6 RPS6KA6 SLC27A4 SLC27A4 SLC27A5 SLC27A5 SLC27A2 SLC27A2 PTPA PTPA PPP1R3B PPP1R3B SREBF1 SREBF1 PRKCD PRKCD PCK2 PCK2 PPARGC1B PPARGC1B IRS2 IRS2 AGT AGT PRKAA1 PRKAA1 SLC2A4 SLC2A4 PRKCQ PRKCQ TNF TNF NFKBIA NFKBIA PPP1R3E PPP1R3E PPP1CB PPP1CB PDPK1 PDPK1 PTEN PTEN PTPN11 PTPN11 MLXIP MLXIP PPP1R3G PPP1R3G NFU1 NFU1 GFPT1 GFPT1 PPP1R3A PPP1R3A PPP1R3C PPP1R3C TBC1D4 TBC1D4 MGEA5 MGEA5 MAPK8 MAPK8 PPP1CC PPP1CC MLXIPL MLXIPL PYGB PYGB PRKCE PRKCE PYGL PYGL SLC27A6 SLC27A6 PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591392 LOC110591392 SLC2A2 SLC2A2 TNIK TNIK G6PC2 G6PC2 CREB1 CREB1 AKT2 AKT2 PRKAB1 PRKAB1 CREB3L3 CREB3L3 PRKAG3 PRKAG3 RPS6KB1 RPS6KB1 PTPRS PTPRS PRKAG1 PRKAG1 INSR INSR PPP1R3D PPP1R3D PCK1 PCK1 FOXO1 FOXO1 LOC110570219 LOC110570219 PIK3CB PIK3CB PPARGC1A PPARGC1A OGT OGT SOCS3 SOCS3 GYS1 GYS1 AKT1 AKT1 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MLXMax-like protein X isoform X1. (321 aa)
SLC27A3Long-chain fatty acid transport protein 3 isoform X1. (649 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
CRTC2CREB-regulated transcription coactivator 2. (695 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (454 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
SLC27A1Long-chain fatty acid transport protein 1. (646 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
RELATranscription factor p65. (531 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1917 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (447 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (453 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
TRIB3Tribbles homolog 3. (358 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
IL6Interleukin-6 isoform X1. (212 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GFPT2Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2. (686 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (568 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
RPS6KA2Ribosomal protein S6 kinase. (727 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
SLC27A5Bile acyl-CoA synthetase. (687 aa)
SLC27A2Very long-chain acyl-CoA synthetase isoform X1. (620 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (323 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X3. (1180 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (1023 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (277 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
MLXIPMLX-interacting protein. (917 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (351 aa)
NFU1NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1. (253 aa)
GFPT1Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1. (820 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1121 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
TBC1D4TBC1 domain family member 4. (1235 aa)
MGEA5Protein O-GlcNAcase. (916 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MLXIPLLOW QUALITY PROTEIN: carbohydrate-responsive element-binding protein. (857 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
SLC27A6Long-chain fatty acid transport protein 6. (619 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
TNIKTRAF2 and NCK-interacting protein kinase. (1360 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (485 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1874 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
INSRTyrosine-protein kinase receptor. (1368 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (622 aa)
FOXO1Forkhead box protein O1. (663 aa)
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (1046 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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