STRINGSTRING
PIK3CD PIK3CD MFF MFF COL4A3 COL4A3 LOC110573272 LOC110573272 AKT3 AKT3 SELE SELE LOC110573273 LOC110573273 XK XK NFKB1 NFKB1 BAX BAX AKT1 AKT1 VEGFD VEGFD TGFBR2 TGFBR2 NOX4 NOX4 PIK3CB PIK3CB TGFB3 TGFB3 COL4A6 COL4A6 PRKCA PRKCA ERAS ERAS COL4A5 COL4A5 FOXO1 FOXO1 PLCD1 PLCD1 LOC110573186 LOC110573186 PIK3R2 PIK3R2 STAT3 STAT3 JUN JUN COL4A4 COL4A4 MAPK13 MAPK13 PIM1 PIM1 PRKCZ PRKCZ MAPK14 MAPK14 PLCB3 PLCB3 RELA RELA VEGFB VEGFB PIK3R3 PIK3R3 AGTR1 AGTR1 CDC42 CDC42 SMAD4 SMAD4 BCL2 BCL2 NOX1 NOX1 CDKN1C CDKN1C CDK4 CDK4 NFATC1 NFATC1 CCND1 CCND1 SMAD2 SMAD2 MAPK12 MAPK12 PRKCB PRKCB PLCB4 PLCB4 PLCG1 PLCG1 MAPK11 MAPK11 MAPK1 MAPK1 LOC110579958 LOC110579958 COL1A2 COL1A2 IL6 IL6 MAPK9 MAPK9 F3 F3 CSDE1 CSDE1 KRAS KRAS LOC110579526 LOC110579526 PLCB1 PLCB1 NRAS NRAS HRAS HRAS PIK3CA PIK3CA VCAM1 VCAM1 CDKN1B CDKN1B NOS3 NOS3 NOX3 NOX3 VEGFA VEGFA TGFBR1 TGFBR1 CASP3 CASP3 VEGFC VEGFC JAK2 JAK2 SERPINE1 SERPINE1 PRKCD PRKCD PLCB2 PLCB2 LOC110583310 LOC110583310 SMAD3 SMAD3 AGT AGT TNF TNF EDN1 EDN1 AGER AGER IL1B IL1B COL4A2 COL4A2 COL4A1 COL4A1 MMP20 MMP20 IL1A IL1A TGFB2 TGFB2 MAPK8 MAPK8 PLCE1 PLCE1 MAPK3 MAPK3 TGFB1 TGFB1 PRKCE PRKCE PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591392 LOC110591392 THBD THBD COL3A1 COL3A1 STAT1 STAT1 FN1 FN1 PLCD4 PLCD4 AKT2 AKT2 EGR1 EGR1 DIAPH1 DIAPH1 CXCL8 CXCL8 LOC110592974 LOC110592974 COL1A1 COL1A1 MMP2 MMP2 ICAM1 ICAM1 PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MFFMitochondrial fission factor isoform X1. (302 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SELEE-selectin. (609 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
XKXK-related protein. (444 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (357 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
COL4A6Collagen alpha-6(IV) chain. (1566 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ERASGTPase ERas. (233 aa)
COL4A5Collagen alpha-5(IV) chain isoform X1. (1691 aa)
FOXO1Forkhead box protein O1. (663 aa)
PLCD1Phosphoinositide phospholipase C. (777 aa)
LOC110573186Cytochrome b-245 heavy chain. (570 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
COL4A4Collagen alpha-4(IV) chain. (1688 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (320 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
RELATranscription factor p65. (531 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
NOX1NADPH oxidase 1. (572 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (891 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
IL6Interleukin-6 isoform X1. (212 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VCAM1Vascular cell adhesion protein 1. (776 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
NOX3NADPH oxidase 3. (566 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
EDN1Endothelin-1. (202 aa)
AGERLOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor. (407 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
COL4A2Collagen alpha-2(IV) chain. (1712 aa)
COL4A1Collagen alpha-1(IV) chain. (1669 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
THBDThrombomodulin. (668 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
FN1Fibronectin isoform X7. (2476 aa)
PLCD4Phosphoinositide phospholipase C. (775 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
DIAPH1Protein diaphanous homolog 1. (1260 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
LOC110592974C-C motif chemokine. (101 aa)
COL1A1Collagen alpha-1(I) chain. (1460 aa)
MMP272 kDa type IV collagenase. (661 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (18%) [HD]