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LOC110579747 LOC110579747 MAP2K1 MAP2K1 LOC110583983 LOC110583983 DVL2 DVL2 AIPL1 AIPL1 RASD1 RASD1 CACNA1D CACNA1D WNT5A WNT5A ITPR1 ITPR1 WNT7A WNT7A PLCB2 PLCB2 ADCY4 ADCY4 USP8 USP8 AGT AGT WNT9A WNT9A CAMK2A CAMK2A ADCY3 ADCY3 E2F3 E2F3 LOC110586781 LOC110586781 FZD3 FZD3 ARSI ARSI POMC POMC ATF6B ATF6B WNT16 WNT16 TCF7L1 TCF7L1 CACNA1H CACNA1H PTRHD1 PTRHD1 PDE8B PDE8B TCF7L2 TCF7L2 CAMK2G CAMK2G KCNK3 KCNK3 LOC110589350 LOC110589350 ADCY9 ADCY9 FZD9 FZD9 FZD10 FZD10 ARMC5 ARMC5 AXIN1 AXIN1 MAPK3 MAPK3 ORAI1 ORAI1 SCARB1 SCARB1 CCNE1 CCNE1 WNT2 WNT2 WNT8A WNT8A WNT8B WNT8B ADCY2 ADCY2 NCEH1 NCEH1 WNT10A WNT10A PDE11A PDE11A APC APC WNT6 WNT6 CREB1 CREB1 TCF7 TCF7 CAMK2B CAMK2B EGFR EGFR CACNA1G CACNA1G WNT10B WNT10B ADCY7 ADCY7 MAP2K2 MAP2K2 ADCY6 ADCY6 APC2 APC2 LDLR LDLR FZD7 FZD7 ADCY1 ADCY1 CREB3L3 CREB3L3 PRKACA PRKACA FZD5 FZD5 ATF2 ATF2 WNT11 WNT11 WNT2B WNT2B AHR AHR HSD3B2 HSD3B2 DVL3 DVL3 KCNA10 KCNA10 ADCY5 ADCY5 WDR5B WDR5B GSK3B GSK3B PRKACB PRKACB BRAF BRAF CDKN1B CDKN1B CREB3L2 CREB3L2 WDR5 WDR5 WNT1 WNT1 GNA11 GNA11 NR4A1 NR4A1 GNAS GNAS LOC110569839 LOC110569839 CTNNB1 CTNNB1 LOC110570357 LOC110570357 WNT9B WNT9B RAP1B RAP1B CACNA1F CACNA1F MRAP MRAP LOC110571031 LOC110571031 WNT3 WNT3 AXIN2 AXIN2 STAR STAR FZD2 FZD2 PDE8A PDE8A CREB3L4 CREB3L4 LOC110572649 LOC110572649 KCNK2 KCNK2 ASH2L ASH2L FH FH MC2R MC2R E2F2 E2F2 CACNA1S CACNA1S DVL1 DVL1 CDKN1A CDKN1A ITPR3 ITPR3 CREB3L1 CREB3L1 PLCB3 PLCB3 CDKN2C CDKN2C MEN1 MEN1 WNT4 WNT4 LEF1 LEF1 AGTR1 AGTR1 KCNA4 KCNA4 FZD4 FZD4 CAMK2D CAMK2D AIP AIP RBBP5 RBBP5 GNAI2 GNAI2 CDKN1C CDKN1C CDK2 CDK2 CDK4 CDK4 CCND1 CCND1 CACNA1I CACNA1I WNT7B WNT7B FZD8 FZD8 ARNT ARNT LOC110578691 LOC110578691 LOC110578976 LOC110578976 CRH CRH CCNE2 CCNE2 SP1 SP1 PLCB4 PLCB4 ATF4 ATF4 MAPK1 MAPK1 RB1 RB1 CDK6 CDK6 GNAI1 GNAI1 FZD1 FZD1 FZD6 FZD6 CREB5 CREB5 KCNA3 KCNA3 KCNA2 KCNA2 RAP1A RAP1A GNAI3 GNAI3 KCNA5 KCNA5 WNT5B WNT5B ITPR2 ITPR2 KCNA1 KCNA1 CACNA1C CACNA1C ADCY8 ADCY8 LOC110579709 LOC110579709 PLCB1 PLCB1 CREB3 CREB3 CRHR2 CRHR2 E2F1 E2F1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC110579747Aryl hydrocarbon receptor-like. (237 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC110583983Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
RASD1Dexamethasone-induced Ras-related protein 1. (279 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
LOC110586781Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (474 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ARSIArylsulfatase I. (575 aa)
POMCPro-opiomelanocortin. (265 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2301 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PDE8BPhosphodiesterase. (911 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
KCNK3Potassium channel subfamily K member. (402 aa)
LOC110589350Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (508 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ARMC5Armadillo repeat-containing protein 5. (943 aa)
AXIN1Axin-1 isoform X1. (867 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (452 aa)
PDE11APhosphodiesterase. (934 aa)
APCAdenomatous polyposis coli protein. (2844 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
TCF7Transcription factor 7. (419 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
APC2Adenomatous polyposis coli protein 2 isoform X1. (2265 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
AHRAryl hydrocarbon receptor. (843 aa)
HSD3B23 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; Belongs to the 3-beta-HSD family. (373 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
WDR5BWD repeat-containing protein 5B. (382 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
WDR5WD repeat-containing protein 5. (334 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC110570357Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family. (421 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
MRAPMelanocortin-2 receptor accessory protein. (90 aa)
LOC110571031Aryl hydrocarbon receptor-like. (606 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
AXIN2Axin-2 isoform X1. (840 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
PDE8APhosphodiesterase. (835 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
LOC110572649Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (422 aa)
ASH2Lset1/Ash2 histone methyltransferase complex subunit ASH2. (628 aa)
FHFumarate hydratase, mitochondrial isoform X1. (508 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
E2F2Transcription factor E2F2. (449 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
MEN1Menin isoform X1. (616 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (424 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (655 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
AIPAH receptor-interacting protein isoform X1. (330 aa)
RBBP5Retinoblastoma-binding protein 5. (531 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2187 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD8Frizzled-8. (243 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (786 aa)
LOC110578691Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (338 aa)
LOC110578976Cytochrome P450 11B1, mitochondrial-like isoform X1; Belongs to the cytochrome P450 family. (503 aa)
CRHCorticoliberin. (196 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
SP1Transcription factor Sp1. (786 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RB1Retinoblastoma-associated protein. (934 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (580 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2 isoform X1; Belongs to the potassium channel family. (499 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
LOC110579709Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (411 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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