STRINGSTRING
ADCY1 ADCY1 FZD7 FZD7 LDLR LDLR APC2 APC2 ADCY6 ADCY6 MAP2K2 MAP2K2 ADCY7 ADCY7 WNT10B WNT10B CACNA1G CACNA1G EGFR EGFR CAMK2B CAMK2B TCF7 TCF7 CREB1 CREB1 WNT6 WNT6 APC APC PDE11A PDE11A WNT10A WNT10A NCEH1 NCEH1 ADCY2 ADCY2 WNT8B WNT8B WNT8A WNT8A WNT2 WNT2 CCNE1 CCNE1 SCARB1 SCARB1 ORAI1 ORAI1 MAPK3 MAPK3 AXIN1 AXIN1 ARMC5 ARMC5 FZD10 FZD10 FZD9 FZD9 ADCY9 ADCY9 LOC110589350 LOC110589350 KCNK3 KCNK3 CAMK2G CAMK2G TCF7L2 TCF7L2 PDE8B PDE8B PTRHD1 PTRHD1 CACNA1H CACNA1H TCF7L1 TCF7L1 WNT16 WNT16 ATF6B ATF6B POMC POMC ARSI ARSI FZD3 FZD3 LOC110586781 LOC110586781 E2F3 E2F3 ADCY3 ADCY3 CAMK2A CAMK2A WNT9A WNT9A AGT AGT USP8 USP8 ADCY4 ADCY4 PLCB2 PLCB2 WNT7A WNT7A ITPR1 ITPR1 WNT5A WNT5A CACNA1D CACNA1D RASD1 RASD1 AIPL1 AIPL1 DVL2 DVL2 LOC110583983 LOC110583983 MAP2K1 MAP2K1 WDR5 WDR5 CREB3L2 CREB3L2 CDKN1B CDKN1B BRAF BRAF PRKACB PRKACB GSK3B GSK3B WDR5B WDR5B ADCY5 ADCY5 KCNA10 KCNA10 DVL3 DVL3 HSD3B2 HSD3B2 AHR AHR WNT2B WNT2B LOC110579747 LOC110579747 E2F1 E2F1 CRHR2 CRHR2 CREB3 CREB3 PLCB1 PLCB1 LOC110579709 LOC110579709 ADCY8 ADCY8 CACNA1C CACNA1C KCNA1 KCNA1 ITPR2 ITPR2 WNT5B WNT5B KCNA5 KCNA5 GNAI3 GNAI3 RAP1A RAP1A KCNA2 KCNA2 KCNA3 KCNA3 CREB5 CREB5 FZD6 FZD6 FZD1 FZD1 GNAI1 GNAI1 CDK6 CDK6 RB1 RB1 MAPK1 MAPK1 ATF4 ATF4 PLCB4 PLCB4 SP1 SP1 CCNE2 CCNE2 CRH CRH LOC110578976 LOC110578976 LOC110578691 LOC110578691 ARNT ARNT FZD8 FZD8 WNT7B WNT7B CACNA1I CACNA1I CCND1 CCND1 CDK4 CDK4 CDK2 CDK2 CDKN1C CDKN1C GNAI2 GNAI2 RBBP5 RBBP5 AIP AIP CAMK2D CAMK2D FZD4 FZD4 KCNA4 KCNA4 AGTR1 AGTR1 LEF1 LEF1 WNT4 WNT4 MEN1 MEN1 CDKN2C CDKN2C PLCB3 PLCB3 CREB3L1 CREB3L1 ITPR3 ITPR3 CDKN1A CDKN1A DVL1 DVL1 CACNA1S CACNA1S E2F2 E2F2 MC2R MC2R FH FH ASH2L ASH2L KCNK2 KCNK2 LOC110572649 LOC110572649 CREB3L4 CREB3L4 PDE8A PDE8A FZD2 FZD2 STAR STAR AXIN2 AXIN2 WNT3 WNT3 LOC110571031 LOC110571031 MRAP MRAP CACNA1F CACNA1F RAP1B RAP1B WNT9B WNT9B LOC110570357 LOC110570357 CTNNB1 CTNNB1 LOC110569839 LOC110569839 GNAS GNAS GNA11 GNA11 WNT1 WNT1 NR4A1 NR4A1 WNT11 WNT11 ATF2 ATF2 FZD5 FZD5 PRKACA PRKACA CREB3L3 CREB3L3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY1Adenylate cyclase type 1. (921 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
APC2Adenomatous polyposis coli protein 2 isoform X1. (2265 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (651 aa)
TCF7Transcription factor 7. (419 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
APCAdenomatous polyposis coli protein. (2844 aa)
PDE11APhosphodiesterase. (934 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (452 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AXIN1Axin-1 isoform X1. (867 aa)
ARMC5Armadillo repeat-containing protein 5. (943 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
LOC110589350Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (508 aa)
KCNK3Potassium channel subfamily K member. (402 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (606 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
PDE8BPhosphodiesterase. (911 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2301 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
POMCPro-opiomelanocortin. (265 aa)
ARSIArylsulfatase I. (575 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
LOC110586781Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (474 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
RASD1Dexamethasone-induced Ras-related protein 1. (279 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
LOC110583983Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WDR5WD repeat-containing protein 5. (334 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
WDR5BWD repeat-containing protein 5B. (382 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
HSD3B23 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; Belongs to the 3-beta-HSD family. (373 aa)
AHRAryl hydrocarbon receptor. (843 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LOC110579747Aryl hydrocarbon receptor-like. (237 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (411 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC110579709Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2 isoform X1; Belongs to the potassium channel family. (499 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (580 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RB1Retinoblastoma-associated protein. (934 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
SP1Transcription factor Sp1. (786 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
CRHCorticoliberin. (196 aa)
LOC110578976Cytochrome P450 11B1, mitochondrial-like isoform X1; Belongs to the cytochrome P450 family. (503 aa)
LOC110578691Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (338 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (786 aa)
FZD8Frizzled-8. (243 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2187 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
RBBP5Retinoblastoma-binding protein 5. (531 aa)
AIPAH receptor-interacting protein isoform X1. (330 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (525 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (655 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (424 aa)
MEN1Menin isoform X1. (616 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
E2F2Transcription factor E2F2. (449 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
FHFumarate hydratase, mitochondrial isoform X1. (508 aa)
ASH2Lset1/Ash2 histone methyltransferase complex subunit ASH2. (628 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (422 aa)
LOC110572649Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
PDE8APhosphodiesterase. (835 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
AXIN2Axin-2 isoform X1. (840 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
LOC110571031Aryl hydrocarbon receptor-like. (606 aa)
MRAPMelanocortin-2 receptor accessory protein. (90 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
LOC110570357Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family. (421 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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