STRINGSTRING
FOS FOS PRKCA PRKCA ERAS ERAS CACNA1F CACNA1F IRS4 IRS4 MAP2K6 MAP2K6 LOC110569839 LOC110569839 GNAS GNAS SSTR5 SSTR5 SHC1 SHC1 STAT3 STAT3 CACNA1S CACNA1S PRKCG PRKCG MAPK13 MAPK13 MAPK14 MAPK14 ITPR3 ITPR3 CREB3L1 CREB3L1 PLCB3 PLCB3 ADCY3 ADCY3 GHRL GHRL MAP2K4 MAP2K4 IRS2 IRS2 ADCY4 ADCY4 PLCB2 PLCB2 RAF1 RAF1 ITPR1 ITPR1 CACNA1D CACNA1D SST SST JAK2 JAK2 MAP2K3 MAP2K3 SHC3 SHC3 MAP2K1 MAP2K1 SHC4 SHC4 CEP152 CEP152 CREB3L2 CREB3L2 PRKACB PRKACB GSK3B GSK3B ADCY5 ADCY5 PIK3CA PIK3CA HRAS HRAS GHRHR GHRHR LOC110582045 LOC110582045 LOC110581983 LOC110581983 LOC110581981 LOC110581981 LOC110581982 LOC110581982 NRAS NRAS CREB3 CREB3 PLCB1 PLCB1 LOC110579709 LOC110579709 MTOR MTOR PIK3R3 PIK3R3 PIK3CD PIK3CD GNAI2 GNAI2 MAPK12 MAPK12 CRKL CRKL PRKCB PRKCB EP300 EP300 PLCB4 PLCB4 PLCG1 PLCG1 ATF4 ATF4 MAPK11 MAPK11 MAPK1 MAPK1 POU1F1 POU1F1 LOC110579958 LOC110579958 GNAI1 GNAI1 SOCS2 SOCS2 IGF1 IGF1 SSTR3 SSTR3 CREB5 CREB5 MAPK9 MAPK9 CSDE1 CSDE1 GNAI3 GNAI3 PTK2 PTK2 KRAS KRAS ITPR2 ITPR2 CACNA1C CACNA1C ADCY8 ADCY8 LOC110579526 LOC110579526 GHRH GHRH SOCS1 SOCS1 CREBBP CREBBP SOS1 SOS1 ATF6B ATF6B PTRHD1 PTRHD1 ADCY9 ADCY9 MAPK8 MAPK8 IGFALS IGFALS MAPK3 MAPK3 GHR GHR SOS2 SOS2 MAP3K1 MAP3K1 PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591392 LOC110591392 ADCY2 ADCY2 STAT1 STAT1 SSTR1 SSTR1 CREB1 CREB1 AKT2 AKT2 IGFBP3 IGFBP3 BCAR1 BCAR1 ADCY7 ADCY7 MAP2K2 MAP2K2 GHSR GHSR ADCY6 ADCY6 ADCY1 ADCY1 CREB3L3 CREB3L3 SHC2 SHC2 PRKACA PRKACA ATF2 ATF2 CRK CRK JUNB JUNB GNA11 GNA11 PLCG2 PLCG2 PIK3R2 PIK3R2 IRS1 IRS1 LOC110573272 LOC110573272 AKT3 AKT3 ADCY10 ADCY10 GRB2 GRB2 CREB3L4 CREB3L4 LOC110573273 LOC110573273 AKT1 AKT1 SOCS3 SOCS3 LOC110571849 LOC110571849 PIK3CB PIK3CB SSTR2 SSTR2 LOC110570393 LOC110570393
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSProto-oncogene c-Fos. (380 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ERASGTPase ERas. (233 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
IRS4Insulin receptor substrate 4. (1244 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
SSTR5Somatostatin receptor type 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2584 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GHRLAppetite-regulating hormone isoform X1. (117 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
IRS2Insulin receptor substrate 2. (1330 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SSTSomatostatin. (116 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
SHC3SHC-transforming protein 3. (469 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
LOC110582045Uncharacterized protein LOC110582045. (205 aa)
LOC110581983Adenylate cyclase type 10-like. (162 aa)
LOC110581981Adenylate cyclase type 10-like. (131 aa)
LOC110581982Adenylate cyclase type 10-like. (313 aa)
NRASGTPase NRas. (189 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC110579709Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CRKLCrk-like protein. (303 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
POU1F1POU domain protein. (317 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
SSTR3Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (422 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
GHRHSomatoliberin. (106 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit. (602 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GHRGrowth hormone receptor. (638 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1393 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (164 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (865 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
SHC2SHC-transforming protein 2. (551 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
JUNBTranscription factor jun-B. (347 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1200 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ADCY10Adenylate cyclase type 10 isoform X1. (1610 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC110571849Insulin receptor substrate 1-like. (404 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
LOC110570393Somatotropin. (216 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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