STRINGSTRING
ATP1A4 ATP1A4 IRS1 IRS1 PIK3R2 PIK3R2 PRKCG PRKCG SCNN1D SCNN1D SFN SFN PIK3R3 PIK3R3 PIK3CD PIK3CD NEDD4L NEDD4L INS INS ATP1B4 ATP1B4 SCNN1B SCNN1B PRKCB PRKCB SCNN1G SCNN1G MAPK1 MAPK1 IGF1 IGF1 ATP1A1 ATP1A1 KRAS KRAS SCNN1A SCNN1A ATP1A3 ATP1A3 PIK3CA PIK3CA LOC110583232 LOC110583232 LOC110582160 LOC110582160 LOC110583655 LOC110583655 FXYD2 FXYD2 KCNJ1 KCNJ1 ATP1B2 ATP1B2 LOC110585337 LOC110585337 PDPK1 PDPK1 SLC9A3R2 SLC9A3R2 NR3C2 NR3C2 MAPK3 MAPK3 PIK3R1 PIK3R1 HSD11B2 HSD11B2 INSR INSR PRKCA PRKCA ATP1B3 ATP1B3 PIK3CB PIK3CB LOC110573336 LOC110573336 ATP1B1 ATP1B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
IRS1Insulin receptor substrate 1. (1236 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SCNN1DAmiloride-sensitive sodium channel subunit delta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (629 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like. (975 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
SCNN1GAmiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
KRASGTPase KRas. (188 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha-3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1121 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC110583232Uncharacterized protein LOC110583232. (149 aa)
LOC110582160FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
LOC110583655LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like. (445 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
KCNJ1ATP-sensitive inward rectifier potassium channel 1. (391 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
LOC110585337Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF2. (226 aa)
NR3C2Mineralocorticoid receptor. (984 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
HSD11B2Corticosteroid 11-beta-dehydrogenase isozyme 2. (407 aa)
INSRTyrosine-protein kinase receptor. (1368 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3. (350 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC110573336Sodium/potassium-transporting ATPase subunit alpha. (1073 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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