(51 nodes) Cocaine addiction network (Neomonachus schauinslandi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATF4	Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
	GRIN3B	Glutamate receptor ionotropic, NMDA 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (910 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	CREB3L3	Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
	PPP1R1B	Protein phosphatase 1 regulatory subunit 1B. (169 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (308 aa)
	DDC	aromatic-L-amino-acid decarboxylase. (480 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (370 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1. (327 aa)
	SLC18A2	Synaptic vesicular amine transporter. (517 aa)
	RGS11	Regulator of G-protein signaling 11. (447 aa)
	ATF6B	Cyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
	GRIA2	Glutamate receptor 2 isoform X1. (940 aa)
	SLC18A1	Chromaffin granule amine transporter isoform X1. (525 aa)
	DRD1	D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	GRIN2A	Glutamate receptor ionotropic, NMDA 2A. (1464 aa)
	GRM2	Metabotropic glutamate receptor 2. (871 aa)
	DRD2	D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	CDK5	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	DLG4	Disks large homolog 4 isoform X2; Belongs to the MAGUK family. (766 aa)
	GRIN1	Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
	CREB3L2	Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	GNAS	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
	GRIN3A	Glutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
	CREB3	Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
	PDYN	proenkephalin-B. (256 aa)
	GPSM1	G-protein-signaling modulator 1 isoform X2. (671 aa)
	GRIN2B	Glutamate receptor ionotropic, NMDA 2B. (1484 aa)
	GNAI3	Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5. (501 aa)
	GRM3	Metabotropic glutamate receptor 3. (879 aa)
	GNAI1	Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (589 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
	TH	Tyrosine 3-monooxygenase isoform X1. (515 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
	RELA	Transcription factor p65. (531 aa)
	CREB3L1	Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
	JUN	Transcription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
	MAOA	Amine oxidase. (527 aa)
	GRIN2D	Glutamate receptor ionotropic, NMDA 2D. (930 aa)
	GRIN2C	Glutamate receptor ionotropic, NMDA 2C isoform X2. (1227 aa)
	CREB3L4	Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
	LOC110573035	Amine oxidase. (411 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
	FOSB	Protein fosB. (338 aa)
	RGS9	Regulator of G-protein signaling 9 isoform X1. (612 aa)
	LOC110569839	Neuroendocrine secretory protein 55. (246 aa)

Your Current Organism:

Neomonachus schauinslandi

NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	GNAI1	A0A2Y9H9D3	A0A2Y9H147	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-1.	0.812
ADCY5	GNAI2	A0A2Y9H9D3	A0A2Y9GTD0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.812
ADCY5	GNAI3	A0A2Y9H9D3	A0A2Y9H2Y1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.812
ADCY5	GNAS	A0A2Y9H9D3	A0A2Y9G3E6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1.	0.999
ADCY5	LOC110569839	A0A2Y9H9D3	A0A2Y9G3M4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Neuroendocrine secretory protein 55.	0.906
ADCY5	PRKACA	A0A2Y9H9D3	A0A2Y9IBD9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.929
ADCY5	PRKACB	A0A2Y9H9D3	A0A2Y9H9M4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	0.929
ATF2	ATF4	A0A2Y9ICB7	A0A2Y9GZZ6	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-dependent transcription factor ATF-4.	0.936
ATF2	ATF6B	A0A2Y9ICB7	A0A2Y9HTZ3	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-dependent transcription factor ATF-6 beta isoform X1.	0.946
ATF2	CREB1	A0A2Y9ICB7	A0A2Y9I4T9	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 1.	0.965
ATF2	CREB3	A0A2Y9ICB7	A0A2Y9H5S1	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 3 isoform X2.	0.944
ATF2	CREB3L1	A0A2Y9ICB7	A0A2Y9GMU2	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 3-like protein 1.	0.927
ATF2	CREB3L2	A0A2Y9ICB7	A0A2Y9HA82	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 3-like protein 2.	0.912
ATF2	CREB3L3	A0A2Y9ICB7	A0A2Y9IAT3	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 3-like protein 3.	0.944
ATF2	CREB3L4	A0A2Y9ICB7	A0A2Y9GF45	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2.	0.826
ATF2	CREB5	A0A2Y9ICB7	A0A2Y9H1S1	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Cyclic AMP-responsive element-binding protein 5.	0.970
ATF2	JUN	A0A2Y9ICB7	A0A2Y9GKE7	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Transcription factor AP-1 isoform X1; Belongs to the bZIP family.	0.995
ATF2	PRKACA	A0A2Y9ICB7	A0A2Y9IBD9	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.935
ATF2	PRKACB	A0A2Y9ICB7	A0A2Y9H9M4	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	0.935
ATF4	ATF2	A0A2Y9GZZ6	A0A2Y9ICB7	Cyclic AMP-dependent transcription factor ATF-4.	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	0.936