STRINGSTRING
HDAC6 HDAC6 ERAS ERAS HDAC4 HDAC4 LOC110570999 LOC110570999 CALM1 CALM1 GNB2 GNB2 LOC110572105 LOC110572105 GNG4 GNG4 ARAF ARAF HDAC8 HDAC8 LOC110572425 LOC110572425 FOSB FOSB GNG8 GNG8 LOC110572885 LOC110572885 HYPM HYPM GNG12 GNG12 LOC110573035 LOC110573035 CREB3L4 CREB3L4 GRB2 GRB2 GRIN2C GRIN2C GRIN2D GRIN2D MAOA MAOA SHC1 SHC1 HDAC5 HDAC5 CALML6 CALML6 CREB3L1 CREB3L1 PPP1CA PPP1CA SLC29A2 SLC29A2 GNB1 GNB1 HDAC1 HDAC1 GNAI2 GNAI2 GNG3 GNG3 TH TH BDNF BDNF LOC110577892 LOC110577892 LOC110578172 LOC110578172 ADORA2A ADORA2A LOC110578727 LOC110578727 PKIA PKIA LOC110578855 LOC110578855 ZC2HC1A ZC2HC1A SLC6A3 SLC6A3 CRH CRH LOC110578114 LOC110578114 ATF4 ATF4 MAPK1 MAPK1 LOC110578552 LOC110578552 GNAI1 GNAI1 HDAC10 HDAC10 HDAC9 HDAC9 CREB5 CREB5 CSDE1 CSDE1 GNAI3 GNAI3 LOC110578551 LOC110578551 KRAS KRAS GRIN2B GRIN2B LOC110580915 LOC110580915 GNB3 GNB3 PDYN PDYN GNG10 GNG10 CREB3 CREB3 GRIN3A GRIN3A GNG11 GNG11 NPY NPY NRAS NRAS GNGT1 GNGT1 SLC29A1 SLC29A1 GNG5 GNG5 HRAS HRAS LOC110580256 LOC110580256 GNB4 GNB4 ADCY5 ADCY5 PRKACB PRKACB BRAF BRAF LOC110582778 LOC110582778 LOC110580854 LOC110580854 CREB3L2 CREB3L2 GRIN1 GRIN1 LOC110583630 LOC110583630 LOC110583566 LOC110583566 CEP152 CEP152 SHC4 SHC4 GNB5 GNB5 LOC110584164 LOC110584164 LOC110581816 LOC110581816 LOC110584201 LOC110584201 SHC3 SHC3 LOC110584545 LOC110584545 ADORA2B ADORA2B ABCF2 ABCF2 RAF1 RAF1 HDAC11 HDAC11 LOC110583620 LOC110583620 HDAC2 HDAC2 CALML4 CALML4 GNAS GNAS LOC110569839 LOC110569839 LOC110570026 LOC110570026 NTRK2 NTRK2 GNG14 GNG14 GRIN3B GRIN3B GNG7 GNG7 LOC110592591 LOC110592591 ATF2 ATF2 GNAO1 GNAO1 PRKACA PRKACA SHC2 SHC2 CREB3L3 CREB3L3 HAT1 HAT1 HDAC7 HDAC7 CAMKK1 CAMKK1 GNGT2 GNGT2 PPP1R1B PPP1R1B DDC DDC LOC110592210 LOC110592210 CREB1 CREB1 LOC110592156 LOC110592156 LOC110589700 LOC110589700 HDAC3 HDAC3 LOC110591142 LOC110591142 SLC18A2 SLC18A2 GNG2 GNG2 CAMK4 CAMK4 SOS2 SOS2 MAPK3 MAPK3 PPP1CC PPP1CC SLC29A3 SLC29A3 LOC110589322 LOC110589322 ATF6B ATF6B SOS1 SOS1 LOC110586609 LOC110586609 LOC110588638 LOC110588638 LOC110586859 LOC110586859 SLC18A1 SLC18A1 LOC110586373 LOC110586373 LOC110586608 LOC110586608 CAMKK2 CAMKK2 DRD1 DRD1 GNG13 GNG13 GRIN2A GRIN2A PPP1CB PPP1CB LOC110585342 LOC110585342 LOC110586604 LOC110586604 LOC110586648 LOC110586648 LOC110586611 LOC110586611 LOC110586605 LOC110586605 LOC110586587 LOC110586587 CALML5 CALML5 DRD2 DRD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC6Histone deacetylase 6 isoform X1. (288 aa)
ERASGTPase ERas. (233 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1028 aa)
LOC110570999Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (484 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
LOC110572105Histone H2A; Belongs to the histone H2A family. (128 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (377 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
FOSBProtein fosB. (338 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC110572885Histone H2A; Belongs to the histone H2A family. (116 aa)
HYPMHuntingtin-interacting protein M. (113 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC110573035Amine oxidase. (411 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C isoform X2. (1227 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (930 aa)
MAOAAmine oxidase. (527 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1134 aa)
CALML6Calmodulin-like protein 6. (232 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SLC29A2Equilibrative nucleoside transporter 2. (456 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
THTyrosine 3-monooxygenase isoform X1. (515 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
LOC110577892Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC110578172Late histone H2B.L4-like; Belongs to the histone H2B family. (136 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
LOC110578727Histone deacetylase 6-like. (546 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
LOC110578855Histone H2B type 2-F-like; Belongs to the histone H2B family. (89 aa)
ZC2HC1AZinc finger C2HC domain-containing protein 1A isoform X2. (324 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (589 aa)
CRHCorticoliberin. (196 aa)
LOC110578114Histone H1.5. (107 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110578552Histone H2B; Belongs to the histone H2B family. (126 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
HDAC10Histone deacetylase 10. (683 aa)
HDAC9Histone deacetylase 9 isoform X1. (611 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC110578551Histone H3; Belongs to the histone H3 family. (136 aa)
KRASGTPase KRas. (188 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1484 aa)
LOC110580915Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
PDYNproenkephalin-B. (256 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
NPYPro-neuropeptide Y. (97 aa)
NRASGTPase NRas. (189 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SLC29A1Equilibrative nucleoside transporter 1 isoform X1. (490 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC110580256Histone H3; Belongs to the histone H3 family. (136 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
LOC110582778Histone H2B; Belongs to the histone H2B family. (173 aa)
LOC110580854Histone H2A; Belongs to the histone H2A family. (129 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
LOC110583630Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC110583566LOW QUALITY PROTEIN: zinc finger C2HC domain-containing protein 1A-like. (325 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
LOC110584164Histone H2A; Belongs to the histone H2A family. (113 aa)
LOC110581816Histone H3; Belongs to the histone H3 family. (136 aa)
LOC110584201Histone H3-like. (69 aa)
SHC3SHC-transforming protein 3. (469 aa)
LOC110584545Histone deacetylase 5-like. (117 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
ABCF2ATP-binding cassette sub-family F member 2. (624 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
HDAC11Histone deacetylase 11. (347 aa)
LOC110583620Histone H2B; Belongs to the histone H2B family. (127 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
LOC110570026Late histone H2B.L4-like; Belongs to the histone H2B family. (174 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (100 aa)
GRIN3BGlutamate receptor ionotropic, NMDA 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (910 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC110592591Histone H2A; Belongs to the histone H2A family. (128 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SHC2SHC-transforming protein 2. (551 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (914 aa)
CAMKK1Calcium/calmodulin-dependent protein kinase kinase 1. (505 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (118 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B. (169 aa)
DDCaromatic-L-amino-acid decarboxylase. (480 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
LOC110589700Histone H2B subacrosomal variant-like; Belongs to the histone H2B family. (122 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
LOC110591142Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
SLC18A2Synaptic vesicular amine transporter. (517 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (470 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
SLC29A3Equilibrative nucleoside transporter 3. (575 aa)
LOC110589322Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (711 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
LOC110586609Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC110588638Histone H3.3C-like. (129 aa)
LOC110586859Histone H2A; Belongs to the histone H2A family. (128 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (525 aa)
LOC110586373Histone H2A; Belongs to the histone H2A family. (143 aa)
LOC110586608Histone H3; Belongs to the histone H3 family. (136 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (578 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC110585342Histone H3; Belongs to the histone H3 family. (128 aa)
LOC110586604Histone H1.1. (215 aa)
LOC110586648Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC110586611Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC110586605Histone H1t. (207 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CALML5Calmodulin-like protein 5. (149 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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