STRINGSTRING
WASL WASL MYD88 MYD88 MAP2K6 MAP2K6 TBK1 TBK1 WAS WAS FOS FOS PIK3CB PIK3CB RAC1 RAC1 LOC110572224 LOC110572224 RAC3 RAC3 AKT1 AKT1 NFKB1 NFKB1 IKBKB IKBKB ACTB ACTB BAIAP2 BAIAP2 RPS6KA3 RPS6KA3 IRF3 IRF3 IL10 IL10 ACTG1 ACTG1 IL2 IL2 AKT3 AKT3 IKBKG IKBKG IRAK1 IRAK1 PIK3R2 PIK3R2 JUN JUN WASF2 WASF2 RPS6KA1 RPS6KA1 MAPK13 MAPK13 MAPK14 MAPK14 ACTL8 ACTL8 LPXN LPXN RELA RELA NLRP10 NLRP10 PIK3R3 PIK3R3 NFATC2 NFATC2 PIK3CD PIK3CD ITGB1 ITGB1 CDC42 CDC42 ROCK1 ROCK1 TRAF6 TRAF6 NFATC1 NFATC1 MAPK12 MAPK12 CRKL CRKL PIP5K1A PIP5K1A ITGA5 ITGA5 PLCG1 PLCG1 RAC2 RAC2 SRC SRC MAPK11 MAPK11 MAPK1 MAPK1 TAB1 TAB1 WIPF3 WIPF3 SKAP2 SKAP2 IL6 IL6 MAPK9 MAPK9 VAV3 VAV3 PTK2 PTK2 CD4 CD4 ELMO2 ELMO2 TRAF2 TRAF2 TLR4 TLR4 NLRP3 NLRP3 PKN2 PKN2 ARHGEF1 ARHGEF1 PIK3CA PIK3CA GSK3B GSK3B RPS6KA2 RPS6KA2 RPS6KA6 RPS6KA6 TAB2 TAB2 VAV2 VAV2 MAP3K7 MAP3K7 MAP2K1 MAP2K1 PIP5K1B PIP5K1B MAP2K3 MAP2K3 ACTR3B ACTR3B LOC110585438 LOC110585438 ARHGEF7 ARHGEF7 ACTR3 ACTR3 FYB1 FYB1 IL18 IL18 MAP2K4 MAP2K4 TNF TNF IFNB1 IFNB1 IL1B IL1B NFKBIA NFKBIA CD8B CD8B ROCK2 ROCK2 MEFV MEFV ARHGEF12 ARHGEF12 PTK2B PTK2B ACTR2 ACTR2 CD8A CD8A NLRC4 NLRC4 CHUK CHUK MAPK8 MAPK8 LCP2 LCP2 LAT LAT DOCK5 DOCK5 MAPK3 MAPK3 LOC110589905 LOC110589905 ELMO1 ELMO1 LOC110590429 LOC110590429 PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591392 LOC110591392 LIMK1 LIMK1 FN1 FN1 AKT2 AKT2 ARHGEF28 ARHGEF28 ARF6 ARF6 CXCL8 CXCL8 LOC110592974 LOC110592974 ACTBL2 ACTBL2 BCAR1 BCAR1 ITGA4 ITGA4 IRAK4 IRAK4 MAP2K2 MAP2K2 GIT2 GIT2 WIPF1 WIPF1 WIPF2 WIPF2 NFATC3 NFATC3 PXN PXN RHOG RHOG DOCK1 DOCK1 PKN1 PKN1 CRK CRK TICAM1 TICAM1 PIP5K1C PIP5K1C MAP2K7 MAP2K7 VAV1 VAV1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WASLNeural Wiskott-Aldrich syndrome protein. (505 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
WASwiskott-Aldrich syndrome protein. (410 aa)
FOSProto-oncogene c-Fos. (380 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
LOC110572224Rho-related GTP-binding protein RhoG-like. (200 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (195 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
ACTBActin, cytoplasmic 1. (375 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (535 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
IRF3Interferon regulatory factor 3 isoform X1. (458 aa)
IL10Interleukin-10. (178 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (726 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (499 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
RELATranscription factor p65. (531 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (648 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (920 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (891 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CRKLCrk-like protein. (303 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
SRCTyrosine-protein kinase. (536 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
WIPF3WAS/WASL-interacting protein family member 3. (351 aa)
SKAP2Src kinase-associated phosphoprotein 2. (359 aa)
IL6Interleukin-6 isoform X1. (212 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
VAV3Guanine nucleotide exchange factor VAV3. (847 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
ELMO2Engulfment and cell motility protein 2. (720 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3. (1036 aa)
PKN2Serine/threonine-protein kinase N2. (984 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (974 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RPS6KA2Ribosomal protein S6 kinase. (727 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
VAV2Guanine nucleotide exchange factor VAV2. (862 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (418 aa)
LOC110585438Uncharacterized protein LOC110585438. (271 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (646 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
FYB1FYN-binding protein isoform X1. (820 aa)
IL18Interleukin-18 isoform X1. (344 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNB1Interferon beta. (182 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
CD8BT-cell surface glycoprotein CD8 beta chain. (210 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1391 aa)
MEFVPyrin isoform X2. (786 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1543 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1010 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (240 aa)
NLRC4LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4. (912 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
LATLinker for activation of T-cells family member 1. (256 aa)
DOCK5Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (1902 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC110589905Apoptosis-associated speck-like protein containing a CARD. (194 aa)
ELMO1Engulfment and cell motility protein 1. (727 aa)
LOC110590429Tyrosine-protein kinase. (616 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
LIMK1LIM domain kinase 1. (644 aa)
FN1Fibronectin isoform X7. (2476 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1388 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
LOC110592974C-C motif chemokine. (101 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (865 aa)
ITGA4LOW QUALITY PROTEIN: integrin alpha-4; Belongs to the integrin alpha chain family. (1039 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GIT2ARF GTPase-activating protein GIT2 isoform X6. (759 aa)
WIPF1WAS/WASL-interacting protein family member 1. (492 aa)
WIPF2WAS/WASL-interacting protein family member 2. (440 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
PXNPaxillin isoform X1; Belongs to the paxillin family. (599 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
DOCK1Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1908 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (950 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (767 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (701 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (440 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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