STRINGSTRING
NR1H3 NR1H3 PIK3CD PIK3CD PIK3R3 PIK3R3 CD81 CD81 CASP9 CASP9 FADD FADD RELA RELA CDKN1A CDKN1A RNASEL RNASEL BAK1 BAK1 E2F2 E2F2 CLDN19 CLDN19 FASLG FASLG MAP2K2 MAP2K2 LDLR LDLR YWHAE YWHAE TICAM1 TICAM1 STAT3 STAT3 PIK3R2 PIK3R2 PSME3 PSME3 EGF EGF IKBKG IKBKG AKT3 AKT3 IRF3 IRF3 GRB2 GRB2 IKBKB IKBKB PPP2R1A PPP2R1A NFKB1 NFKB1 JAK1 JAK1 BAX BAX AKT1 AKT1 EIF2AK1 EIF2AK1 SOCS3 SOCS3 EIF2S1 EIF2S1 ARAF ARAF MX2 MX2 TRAF3 TRAF3 PIK3CB PIK3CB IFNAR2 IFNAR2 MX1 MX1 ERAS ERAS PPP2R2C PPP2R2C CLDN18 CLDN18 TBK1 TBK1 IFNG IFNG CTNNB1 CTNNB1 CLDN2 CLDN2 CLDN8 CLDN8 IFNAR1 IFNAR1 CLDN14 CLDN14 CLDN34 CLDN34 IKBKE IKBKE BAD BAD CDK2 CDK2 CDK4 CDK4 STAT2 STAT2 TRAF6 TRAF6 PPARA PPARA APAF1 APAF1 CCND1 CCND1 MYC MYC YWHAZ YWHAZ EIF3E EIF3E YWHAB YWHAB MAPK1 MAPK1 RB1 RB1 CDK6 CDK6 CUNH7orf31 CUNH7orf31 CSDE1 CSDE1 BID BID KRAS KRAS TNFRSF1A TNFRSF1A CLDN17 CLDN17 TRAF2 TRAF2 LOC110579961 LOC110579961 MAVS MAVS RXRA RXRA E2F1 E2F1 NRAS NRAS HRAS HRAS PIK3CA PIK3CA CLDN1 CLDN1 LOC110582476 LOC110582476 GSK3B GSK3B BRAF BRAF CLDN5 CLDN5 CLDN20 CLDN20 DDX58 DDX58 MAP2K1 MAP2K1 CASP3 CASP3 PPP2CB PPP2CB IRF7 IRF7 LOC110584242 LOC110584242 TP53 TP53 CLDN16 CLDN16 RAF1 RAF1 EIF2AK4 EIF2AK4 PIAS1 PIAS1 FAS FAS LOC110586049 LOC110586049 PPP2R1B PPP2R1B TLR3 TLR3 LOC110584232 LOC110584232 CLDN23 CLDN23 CLDN7 CLDN7 RIPK1 RIPK1 TNF TNF IFNB1 IFNB1 EIF2AK3 EIF2AK3 EIF2AK2 EIF2AK2 NFKBIA NFKBIA RSAD2 RSAD2 YWHAQ YWHAQ IRF9 IRF9 CLDN10 CLDN10 LOC110586048 LOC110586048 CLDN9 CLDN9 LOC110586047 LOC110586047 CLDN25 CLDN25 OAS1 OAS1 OAS3 OAS3 OAS2 OAS2 PPP2R2A PPP2R2A E2F3 E2F3 LOC110587131 LOC110587131 SOS1 SOS1 IFNA5 IFNA5 CHUK CHUK CLDN6 CLDN6 OCLN OCLN MAPK3 MAPK3 CLDN3 CLDN3 SCARB1 SCARB1 SOS2 SOS2 LOC110589308 LOC110589308 PIK3R1 PIK3R1 YWHAG YWHAG PPP2R2B PPP2R2B CLDN11 CLDN11 CLDN4 CLDN4 LOC110592054 LOC110592054 STAT1 STAT1 CFLAR CFLAR AKT2 AKT2 YWHAH YWHAH EGFR EGFR PPP1R14B PPP1R14B TRADD TRADD PPP2CA PPP2CA CASP8 CASP8 CXCL10 CXCL10 TYK2 TYK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR1H3Oxysterols receptor LXR-alpha isoform X1. (447 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
CD81Tetraspanin. (165 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (447 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
RELATranscription factor p65. (531 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RNASELLOW QUALITY PROTEIN: 2-5A-dependent ribonuclease. (730 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
E2F2Transcription factor E2F2. (449 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (281 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (767 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
PSME3Proteasome activator complex subunit 3. (254 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRF3Interferon regulatory factor 3 isoform X1. (458 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1. (630 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
MX2Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (516 aa)
MX1Interferon-induced GTP-binding protein Mx1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
ERASGTPase ERas. (233 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CTNNB1Catenin beta-1. (781 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
CLDN34Claudin-34. (215 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (774 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RB1Retinoblastoma-associated protein. (934 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog. (590 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (240 aa)
KRASGTPase KRas. (188 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
LOC110579961Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (547 aa)
RXRARetinoic acid receptor RXR-alpha. (413 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC110582476Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (155 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (309 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
DDX58Probable ATP-dependent RNA helicase DDX58. (995 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
IRF7Interferon regulatory factor 7. (496 aa)
LOC110584242Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (384 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
EIF2AK4eIF-2-alpha kinase GCN2. (1653 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (651 aa)
FASTumor necrosis factor receptor superfamily member 6. (314 aa)
LOC110586049Interferon-induced protein with tetratricopeptide repeats 1-like. (480 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
LOC110584232Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (291 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNB1Interferon beta. (182 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1114 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (541 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (363 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
IRF9Interferon regulatory factor 9. (410 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
LOC110586048Interferon-induced protein with tetratricopeptide repeats 1B-like isoform X1. (501 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
LOC110586047Interferon-induced protein with tetratricopeptide repeats 3-like isoform X1. (499 aa)
CLDN25Putative claudin-25. (228 aa)
OAS12'-5'-oligoadenylate synthase 1. (444 aa)
OAS3LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3. (1089 aa)
OAS22'-5'-oligoadenylate synthase 2. (685 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
LOC110587131Interferon alpha-16-like. (182 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
IFNA5LOW QUALITY PROTEIN: interferon alpha-5. (187 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
LOC110589308Interferon-induced protein with tetratricopeptide repeats 5. (482 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
LOC110592054Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (312 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CASP8LOW QUALITY PROTEIN: caspase-8; Belongs to the peptidase C14A family. (486 aa)
CXCL10C-X-C motif chemokine. (98 aa)
TYK2Tyrosine-protein kinase. (1189 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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