STRINGSTRING
MYD88 MYD88 IFNAR1 IFNAR1 SLC25A6 SLC25A6 KPNA2 KPNA2 NXT2 NXT2 IFNG IFNG TBK1 TBK1 RAE1 RAE1 IFNGR2 IFNGR2 TMPRSS2 TMPRSS2 MX1 MX1 IFNAR2 IFNAR2 PRKCA PRKCA CPSF4L CPSF4L DNAJB4 DNAJB4 PIK3CB PIK3CB TRAF3 TRAF3 MX2 MX2 KPNA7 KPNA7 CPSF4 CPSF4 EIF2S1 EIF2S1 LOC110572446 LOC110572446 SOCS3 SOCS3 KLK8 KLK8 AKT1 AKT1 BAX BAX JAK1 JAK1 KLK14 KLK14 NFKB1 NFKB1 KLK12 KLK12 KLK11 KLK11 SLC25A31 SLC25A31 IKBKB IKBKB ACTB ACTB FDPS FDPS ADAR ADAR IL33 IL33 IRF3 IRF3 TRIM65 TRIM65 ACTG1 ACTG1 KLK13 KLK13 AKT3 AKT3 IKBKG IKBKG KLK15 KLK15 PIK3R2 PIK3R2 KPNA6 KPNA6 FASLG FASLG LOC110575560 LOC110575560 BAK1 BAK1 LOC110575557 LOC110575557 LOC110575634 LOC110575634 LOC110575559 LOC110575559 RNASEL RNASEL ACTL8 ACTL8 RELA RELA FADD FADD LOC110576115 LOC110576115 TLR7 TLR7 CASP9 CASP9 SLC25A5 SLC25A5 NXF1 NXF1 NLRP10 NLRP10 PIK3R3 PIK3R3 LOC110575569 LOC110575569 PIK3CD PIK3CD LOC110575638 LOC110575638 LOC110575567 LOC110575567 LOC110576070 LOC110576070 IKBKE IKBKE LOC110575636 LOC110575636 CDK4 CDK4 STAT2 STAT2 APAF1 APAF1 TMEM223 TMEM223 PRKCB PRKCB EP300 EP300 MAPK1 MAPK1 CDK6 CDK6 IL6 IL6 CUNH7orf31 CUNH7orf31 BID BID TNFRSF1A TNFRSF1A LOC110579961 LOC110579961 MAVS MAVS TLR4 TLR4 NLRP3 NLRP3 PIK3CA PIK3CA PRSS37 PRSS37 PRSS2 PRSS2 LOC110582989 LOC110582989 DDX58 DDX58 RAB11A RAB11A STOML1 STOML1 CCND3 CCND3 MAP2K1 MAP2K1 CASP3 CASP3 IRF7 IRF7 LOC110581940 LOC110581940 JAK2 JAK2 NXF3 NXF3 KPNA1 KPNA1 RAF1 RAF1 PLG PLG IFNGR1 IFNGR1 LOC110585402 LOC110585402 KPNA5 KPNA5 LOC110585694 LOC110585694 DNAJC3 DNAJC3 FAS FAS TMPRSS4 TMPRSS4 PML PML SLC25A4 SLC25A4 TLR3 TLR3 IL18 IL18 TNF TNF LOC110586769 LOC110586769 IFNB1 IFNB1 IL1B IL1B EIF2AK2 EIF2AK2 NFKBIA NFKBIA RSAD2 RSAD2 IRF9 IRF9 LOC110587829 LOC110587829 LOC110588010 LOC110588010 CREBBP CREBBP NLRX1 NLRX1 OAS1 OAS1 OAS3 OAS3 OAS2 OAS2 LOC110586514 LOC110586514 LOC110587131 LOC110587131 IL1A IL1A IFNA5 IFNA5 LOC110587672 LOC110587672 LOC110587828 LOC110587828 NXF5 NXF5 CHUK CHUK IL12B IL12B MAPK3 MAPK3 LOC110589905 LOC110589905 NXT1 NXT1 XPO1 XPO1 PIK3R1 PIK3R1 LOC110591358 LOC110591358 LOC110591359 LOC110591359 LOC110591357 LOC110591357 LOC110591413 LOC110591413 LOC110591485 LOC110591485 NFKBIB NFKBIB IFIH1 IFIH1 LOC110592054 LOC110592054 STAT1 STAT1 HNRNPUL1 HNRNPUL1 AKT2 AKT2 VDAC1 VDAC1 CXCL8 CXCL8 LOC110591355 LOC110591355 TRIM25 TRIM25 LOC110592974 LOC110592974 TRADD TRADD IL12A IL12A CCL5 CCL5 ACTBL2 ACTBL2 TMPRSS11D TMPRSS11D DNAJB13 DNAJB13 CASP8 CASP8 CXCL10 CXCL10 IRAK4 IRAK4 TYK2 TYK2 TNFSF10 TNFSF10 MAP2K2 MAP2K2 PABPN1L PABPN1L ICAM1 ICAM1 CALCOCO2 CALCOCO2 COIL COIL RNF135 RNF135 NUP98 NUP98 TICAM1 TICAM1 RAB11B RAB11B DNAJB1 DNAJB1 LOC110594300 LOC110594300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (284 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
NXT2NTF2-related export protein 2. (257 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
RAE1mRNA export factor. (368 aa)
IFNGR2Interferon gamma receptor 2 isoform X1. (356 aa)
TMPRSS2Transmembrane protease serine 2; Belongs to the peptidase S1 family. (521 aa)
MX1Interferon-induced GTP-binding protein Mx1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (516 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CPSF4Lannotation not available (165 aa)
DNAJB4dnaJ homolog subfamily B member 4 isoform X1. (337 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
MX2Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (523 aa)
CPSF4Cleavage and polyadenylation specificity factor subunit 4 isoform X3. (244 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
LOC110572446LOW QUALITY PROTEIN: E3 ubiquitin/ISG15 ligase TRIM25-like. (604 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
KLK8Kallikrein-8; Belongs to the peptidase S1 family. (235 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
KLK14Kallikrein-14; Belongs to the peptidase S1 family. (251 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
KLK12Kallikrein-12; Belongs to the peptidase S1 family. (264 aa)
KLK11Kallikrein-11; Belongs to the peptidase S1 family. (249 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
ACTBActin, cytoplasmic 1. (375 aa)
FDPSFarnesyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family. (420 aa)
ADARDouble-stranded RNA-specific adenosine deaminase isoform X1. (1171 aa)
IL33Interleukin-33. (267 aa)
IRF3Interferon regulatory factor 3 isoform X1. (458 aa)
TRIM65Tripartite motif-containing protein 65 isoform X1. (521 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
KLK13Kallikrein-13; Belongs to the peptidase S1 family. (278 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
KLK15Kallikrein-15 isoform X1; Belongs to the peptidase S1 family. (255 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (536 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (281 aa)
LOC110575560HLA class II histocompatibility antigen, DO beta chain. (273 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
LOC110575557HLA class II histocompatibility antigen, DQ alpha 2 chain-like; Belongs to the MHC class II family. (255 aa)
LOC110575634HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (291 aa)
LOC110575559HLA class II histocompatibility antigen, DQ beta 1 chain-like. (269 aa)
RNASELLOW QUALITY PROTEIN: 2-5A-dependent ribonuclease. (730 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
RELATranscription factor p65. (531 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
LOC110576115Nuclear RNA export factor 3-like. (254 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (447 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (294 aa)
NXF1Nuclear RNA export factor 1. (618 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (648 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
LOC110575569HLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (261 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC110575638LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like. (245 aa)
LOC110575567HLA class II histocompatibility antigen, DM beta chain. (263 aa)
LOC110576070Tumor necrosis factor receptor superfamily member 1A-like isoform X1. (459 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (774 aa)
LOC110575636HLA class II histocompatibility antigen, DP alpha 1 chain; Belongs to the MHC class II family. (269 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
TMEM223Transmembrane protein 223. (196 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
EP300Histone acetyltransferase p300. (2420 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IL6Interleukin-6 isoform X1. (212 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog. (590 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (240 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
LOC110579961Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (547 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3. (1036 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRSS37Probable inactive serine protease 37. (235 aa)
PRSS2Trypsin-2; Belongs to the peptidase S1 family. (248 aa)
LOC110582989Cationic trypsin isoform X1; Belongs to the peptidase S1 family. (246 aa)
DDX58Probable ATP-dependent RNA helicase DDX58. (995 aa)
RAB11ARas-related protein Rab-11A. (216 aa)
STOML1Stomatin-like protein 1 isoform X1. (398 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (291 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
IRF7Interferon regulatory factor 7. (496 aa)
LOC110581940Tripartite motif-containing protein 47. (645 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
NXF3LOW QUALITY PROTEIN: nuclear RNA export factor 3. (581 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
IFNGR1LOW QUALITY PROTEIN: interferon gamma receptor 1. (474 aa)
LOC110585402Polyadenylate-binding protein 2. (306 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
LOC110585694Importin subunit alpha-8-like. (365 aa)
DNAJC3dnaJ homolog subfamily C member 3 isoform X1. (504 aa)
FASTumor necrosis factor receptor superfamily member 6. (314 aa)
TMPRSS4Transmembrane protease serine 4 isoform X1; Belongs to the peptidase S1 family. (446 aa)
PMLProtein PML isoform X1. (880 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
IL18Interleukin-18 isoform X1. (344 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC110586769LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
IFNB1Interferon beta. (182 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (541 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (363 aa)
IRF9Interferon regulatory factor 9. (410 aa)
LOC110587829MHC class II transactivator-like. (1121 aa)
LOC110588010Tryptase-like; Belongs to the peptidase S1 family. (275 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
NLRX1NLR family member X1 isoform X1. (975 aa)
OAS12'-5'-oligoadenylate synthase 1. (444 aa)
OAS3LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3. (1089 aa)
OAS22'-5'-oligoadenylate synthase 2. (685 aa)
LOC110586514Importin subunit alpha; Functions in nuclear protein import. (483 aa)
LOC110587131Interferon alpha-16-like. (182 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IFNA5LOW QUALITY PROTEIN: interferon alpha-5. (187 aa)
LOC110587672Nuclear RNA export factor 2-like. (561 aa)
LOC110587828MHC class II transactivator-like. (103 aa)
NXF5Nuclear RNA export factor 5. (560 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC110589905Apoptosis-associated speck-like protein containing a CARD. (194 aa)
NXT1NTF2-related export protein 1. (140 aa)
XPO1Exportin-1. (1071 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591358Transmembrane protease serine; Belongs to the peptidase S1 family. (400 aa)
LOC110591359LOW QUALITY PROTEIN: transmembrane protease serine 11B-like; Belongs to the peptidase S1 family. (516 aa)
LOC110591357LOW QUALITY PROTEIN: transmembrane protease serine 11A-like; Belongs to the peptidase S1 family. (445 aa)
LOC110591413Transmembrane protease serine; Belongs to the peptidase S1 family. (422 aa)
LOC110591485Transmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X1. (354 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1026 aa)
LOC110592054Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
HNRNPUL1Heterogeneous nuclear ribonucleoprotein U-like protein 1. (856 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
LOC110591355Transmembrane protease serine; Belongs to the peptidase S1 family. (439 aa)
TRIM25E3 ubiquitin/ISG15 ligase TRIM25. (636 aa)
LOC110592974C-C motif chemokine. (101 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (312 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
CCL5C-C motif chemokine. (91 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
DNAJB13dnaJ homolog subfamily B member 13. (316 aa)
CASP8LOW QUALITY PROTEIN: caspase-8; Belongs to the peptidase C14A family. (486 aa)
CXCL10C-X-C motif chemokine. (98 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
TYK2Tyrosine-protein kinase. (1189 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (286 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PABPN1LLOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2. (310 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2. (449 aa)
COILCoilin. (576 aa)
RNF135E3 ubiquitin-protein ligase RNF135. (402 aa)
NUP98Nuclear pore complex protein Nup98-Nup96 isoform X1. (1817 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (767 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
DNAJB1dnaJ homolog subfamily B member 1. (340 aa)
LOC110594300LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like. (282 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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