STRINGSTRING
PLD1 PLD1 BRCA2 BRCA2 TGFB3 TGFB3 PIK3CB PIK3CB GADD45A GADD45A TGFBR2 TGFBR2 RAC1 RAC1 ARAF ARAF RAC3 RAC3 AKT1 AKT1 BAX BAX JAK1 JAK1 NFKB1 NFKB1 IKBKB IKBKB AKT3 AKT3 IKBKG IKBKG PIK3R2 PIK3R2 STAT3 STAT3 E2F2 E2F2 EGF EGF BAK1 BAK1 CDKN1A CDKN1A DDB2 DDB2 RELA RELA RPS6KB2 RPS6KB2 CASP9 CASP9 MTOR MTOR PIK3R3 PIK3R3 PIK3CD PIK3CD CDC42 CDC42 SMAD4 SMAD4 PPP1R14B PPP1R14B ARHGEF6 ARHGEF6 BAD BAD CDK4 CDK4 CCND1 CCND1 SMAD2 SMAD2 RAC2 RAC2 MAPK1 MAPK1 RB1 RB1 RALBP1 RALBP1 CDK6 CDK6 MAPK9 MAPK9 KRAS KRAS RALGDS RALGDS BCL2L1 BCL2L1 E2F1 E2F1 PIK3CA PIK3CA BRAF BRAF VEGFA VEGFA TGFBR1 TGFBR1 GADD45G GADD45G TP53 TP53 RAF1 RAF1 RAD51 RAD51 LOC110583310 LOC110583310 SMAD3 SMAD3 PLD2 PLD2 POLK POLK RALB RALB E2F3 E2F3 TGFA TGFA CHUK CHUK TGFB2 TGFB2 MAPK8 MAPK8 MAPK3 MAPK3 TGFB1 TGFB1 PIK3R1 PIK3R1 LOC110591391 LOC110591391 LOC110591392 LOC110591392 STAT1 STAT1 AKT2 AKT2 RALA RALA EGFR EGFR ERBB2 ERBB2 RPS6KB1 RPS6KB1 GADD45B GADD45B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLD1Phospholipase. (1040 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3446 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (195 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
E2F2Transcription factor E2F2. (449 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
DDB2DNA damage-binding protein 2. (412 aa)
RELATranscription factor p65. (531 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (447 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (771 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RB1Retinoblastoma-associated protein. (934 aa)
RALBP1ralA-binding protein 1 isoform X1. (634 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
KRASGTPase KRas. (188 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (886 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma isoform X1. (175 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
LOC110583310Mothers against decapentaplegic homolog. (451 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PLD2Phospholipase. (933 aa)
POLKDNA polymerase kappa. (826 aa)
RALBRas-related protein Ral-B. (206 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
TGFAProtransforming growth factor alpha. (160 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RALARas-related protein Ral-A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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