STRINGSTRING
MMP10 MMP10 FOXO1 FOXO1 LOC110570219 LOC110570219 CTNNB1 CTNNB1 LOC110570615 LOC110570615 ERAS ERAS TMPRSS2 TMPRSS2 MDM2 MDM2 PIK3CB PIK3CB HSP90AA1 HSP90AA1 PDGFA PDGFA ERG ERG ARAF ARAF IGF1R IGF1R AR AR AKT1 AKT1 IL1R2 IL1R2 NFKB1 NFKB1 PLAT PLAT IKBKB IKBKB FGFR1 FGFR1 INSRR INSRR CREB3L4 CREB3L4 GRB2 GRB2 AKT3 AKT3 IKBKG IKBKG PIK3R2 PIK3R2 E2F2 E2F2 EGF EGF CDKN1A CDKN1A CREB3L1 CREB3L1 RELA RELA LOC110576050 LOC110576050 LOC110576049 LOC110576049 CASP9 CASP9 MTOR MTOR PIK3R3 PIK3R3 LEF1 LEF1 PIK3CD PIK3CD BCL2 BCL2 PPP1R14B PPP1R14B ZEB1 ZEB1 BAD BAD CDKN1C CDKN1C INS INS CDK2 CDK2 HSP90B1 HSP90B1 CCND1 CCND1 CCNE2 CCNE2 EP300 EP300 MMP9 MMP9 ATF4 ATF4 MAPK1 MAPK1 RB1 RB1 IGF1 IGF1 PDGFB PDGFB CREB5 CREB5 CSDE1 CSDE1 KRAS KRAS CREB3 CREB3 E2F1 E2F1 NRAS NRAS HSP90AB1 HSP90AB1 HRAS HRAS PIK3CA PIK3CA GSK3B GSK3B BRAF BRAF CDKN1B CDKN1B CREB3L2 CREB3L2 MAP2K1 MAP2K1 TP53 TP53 RAF1 RAF1 SPINT1 SPINT1 LOC110586166 LOC110586166 MMP12 MMP12 PDGFD PDGFD PDGFRB PDGFRB NFKBIA NFKBIA PDPK1 PDPK1 PTEN PTEN CREBBP CREBBP PDGFC PDGFC E2F3 E2F3 NKX3-1 NKX3-1 SOS1 SOS1 TGFA TGFA TCF7L1 TCF7L1 PLAU PLAU CHUK CHUK TCF7L2 TCF7L2 SRD5A2 SRD5A2 NKX2-3 NKX2-3 MAPK3 MAPK3 CCNE1 CCNE1 SOS2 SOS2 PIK3R1 PIK3R1 CREB1 CREB1 AKT2 AKT2 PDGFRA PDGFRA TCF7 TCF7 EGFR EGFR FGFR2 FGFR2 ERBB2 ERBB2 MAP2K2 MAP2K2 CREB3L3 CREB3L3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP10Stromelysin-2. (476 aa)
FOXO1Forkhead box protein O1. (663 aa)
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC110570615Glutathione S-transferase P-like; Belongs to the GST superfamily. (180 aa)
ERASGTPase ERas. (233 aa)
TMPRSS2Transmembrane protease serine 2; Belongs to the peptidase S1 family. (521 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
ERGTranscriptional regulator ERG. (393 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ARAndrogen receptor isoform X1. (921 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL1R2Interleukin-1 receptor type 2 isoform X1. (418 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
INSRRTyrosine-protein kinase receptor. (1300 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2. (394 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
E2F2Transcription factor E2F2. (449 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
RELATranscription factor p65. (531 aa)
LOC110576050Glutathione S-transferase P; Belongs to the GST superfamily. (210 aa)
LOC110576049Glutathione S-transferase P-like. (210 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (447 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (905 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
HSP90B1LOW QUALITY PROTEIN: endoplasmin. (804 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
EP300Histone acetyltransferase p300. (2420 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RB1Retinoblastoma-associated protein. (934 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (501 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (352 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
NRASGTPase NRas. (189 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
SPINT1Kunitz-type protease inhibitor 1 isoform X1. (511 aa)
LOC110586166Stromelysin-1. (476 aa)
MMP12Macrophage metalloelastase. (470 aa)
PDGFDPlatelet-derived growth factor D. (335 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CREBBPCREB-binding protein isoform X3. (2433 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
TGFAProtransforming growth factor alpha. (160 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
PLAUUrokinase-type plasminogen activator. (432 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
NKX2-3Homeobox protein Nkx-2.3. (369 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TCF7Transcription factor 7. (419 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (302 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.