STRINGSTRING
GADD45B GADD45B BAX BAX GADD45A GADD45A ERAS ERAS CTNNB1 CTNNB1 LOC110593709 LOC110593709 CDH1 CDH1 MAP2K2 MAP2K2 TCF7 TCF7 NCOA4 NCOA4 MAPK3 MAPK3 RXRG RXRG RET RET TCF7L2 TCF7L2 CCDC6 CCDC6 TCF7L1 TCF7L1 POLK POLK PAX8 PAX8 PPARG PPARG TP53 TP53 GADD45G GADD45G MAP2K1 MAP2K1 BRAF BRAF TFG TFG HRAS HRAS NRAS NRAS RXRA RXRA KRAS KRAS CSDE1 CSDE1 MAPK1 MAPK1 MYC MYC CCND1 CCND1 LEF1 LEF1 DDB2 DDB2 CDKN1A CDKN1A RXRB RXRB TPR TPR BAK1 BAK1 NTRK1 NTRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
ERASGTPase ERas. (233 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC110593709LOW QUALITY PROTEIN: cadherin-1-like. (506 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TCF7Transcription factor 7. (419 aa)
NCOA4Nuclear receptor coactivator 4 isoform X1. (634 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1131 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
CCDC6Coiled-coil domain-containing protein 6. (476 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
POLKDNA polymerase kappa. (826 aa)
PAX8Paired box protein Pax-8. (490 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (542 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma isoform X1. (175 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
TFGProtein TFG. (401 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
RXRARetinoic acid receptor RXR-alpha. (413 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
DDB2DNA damage-binding protein 2. (412 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RXRBLOW QUALITY PROTEIN: retinoic acid receptor RXR-beta. (532 aa)
TPRNucleoprotein TPR isoform X3. (2363 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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