STRINGSTRING
WNT10A WNT10A KIF27 KIF27 CTNNB1 CTNNB1 WNT9B WNT9B PTCH1 PTCH1 WNT3 WNT3 AXIN2 AXIN2 GADD45A GADD45A KIF7 KIF7 HHIP HHIP BAX BAX FZD2 FZD2 PTCH2 PTCH2 DVL1 DVL1 BAK1 BAK1 CDKN1A CDKN1A DDB2 DDB2 WNT4 WNT4 LEF1 LEF1 FZD4 FZD4 GLI1 GLI1 WNT7B WNT7B FZD8 FZD8 LOC110578691 LOC110578691 BMP2 BMP2 FZD1 FZD1 FZD6 FZD6 WNT5B WNT5B WNT2B WNT2B DVL3 DVL3 GSK3B GSK3B GADD45G GADD45G DVL2 DVL2 TP53 TP53 WNT5A WNT5A WNT7A WNT7A GLI2 GLI2 WNT9A WNT9A POLK POLK FZD3 FZD3 WNT16 WNT16 TCF7L1 TCF7L1 SUFU SUFU TCF7L2 TCF7L2 FZD9 FZD9 FZD10 FZD10 AXIN1 AXIN1 SMO SMO WNT2 WNT2 WNT8A WNT8A WNT8B WNT8B APC APC WNT6 WNT6 TCF7 TCF7 GLI3 GLI3 BMP4 BMP4 WNT10B WNT10B APC2 APC2 FZD7 FZD7 FZD5 FZD5 WNT11 WNT11 WNT1 WNT1 GADD45B GADD45B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (452 aa)
KIF27Kinesin-like protein KIF27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
PTCH1Protein patched homolog 1. (1301 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
AXIN2Axin-2 isoform X1. (840 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
KIF7Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1301 aa)
HHIPHedgehog-interacting protein. (700 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
PTCH2LOW QUALITY PROTEIN: protein patched homolog 2. (1207 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
DDB2DNA damage-binding protein 2. (412 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (424 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
GLI1LOW QUALITY PROTEIN: zinc finger protein GLI1. (1105 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD8Frizzled-8. (243 aa)
LOC110578691Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (338 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma isoform X1. (175 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
GLI2Zinc finger protein GLI2. (1415 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
POLKDNA polymerase kappa. (826 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
AXIN1Axin-1 isoform X1. (867 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
APCAdenomatous polyposis coli protein. (2844 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
TCF7Transcription factor 7. (419 aa)
GLI3Transcriptional activator GLI3. (1589 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
APC2Adenomatous polyposis coli protein 2 isoform X1. (2265 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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