STRINGSTRING
FGF23 FGF23 FGF22 FGF22 GADD45B GADD45B LOC110593709 LOC110593709 CDH1 CDH1 MAP2K2 MAP2K2 EGFR EGFR PDGFRA PDGFRA AKT2 AKT2 FGF5 FGF5 PIK3R1 PIK3R1 FGF1 FGF1 MAPK3 MAPK3 FGF8 FGF8 MET MET FGF17 FGF17 E2F3 E2F3 PDGFC PDGFC FGF10 FGF10 FGF18 FGF18 PTEN PTEN POLK POLK MITF MITF PDGFRB PDGFRB PDGFD PDGFD RAF1 RAF1 TP53 TP53 FGF20 FGF20 GADD45G GADD45G MAP2K1 MAP2K1 FGF7 FGF7 GALK2 GALK2 FGF6 FGF6 BRAF BRAF PIK3CA PIK3CA HRAS HRAS NRAS NRAS E2F1 E2F1 HGF HGF KRAS KRAS CSDE1 CSDE1 PDGFB PDGFB IGF1 IGF1 CDK6 CDK6 RB1 RB1 MAPK1 MAPK1 FGF16 FGF16 CCND1 CCND1 CDK4 CDK4 BAD BAD FGF19 FGF19 FGF4 FGF4 PPP1R14B PPP1R14B PIK3CD PIK3CD PIK3R3 PIK3R3 FGF3 FGF3 DDB2 DDB2 CDKN1A CDKN1A BAK1 BAK1 EGF EGF E2F2 E2F2 PIK3R2 PIK3R2 AKT3 AKT3 FGF2 FGF2 FGFR1 FGFR1 BAX BAX FGF21 FGF21 AKT1 AKT1 IGF1R IGF1R ARAF ARAF PDGFA PDGFA GADD45A GADD45A PIK3CB PIK3CB MDM2 MDM2 ERAS ERAS LOC110570219 LOC110570219 FGF9 FGF9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
LOC110593709LOW QUALITY PROTEIN: cadherin-1-like. (506 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
METHepatocyte growth factor receptor. (1382 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
POLKDNA polymerase kappa. (826 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (504 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
PDGFDPlatelet-derived growth factor D. (335 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma isoform X1. (175 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GALK2N-acetylgalactosamine kinase. (461 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RB1Retinoblastoma-associated protein. (934 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
DDB2DNA damage-binding protein 2. (412 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
E2F2Transcription factor E2F2. (449 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (374 aa)
FGFR1Fibroblast growth factor receptor. (735 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
ERASGTPase ERas. (233 aa)
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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