STRINGSTRING
DAPK3 DAPK3 LOC110593709 LOC110593709 DAPK1 DAPK1 FGFR3 FGFR3 ERAS ERAS MDM2 MDM2 RPS6KA5 RPS6KA5 ARAF ARAF E2F2 E2F2 EGF EGF CDKN1A CDKN1A CDK4 CDK4 CCND1 CCND1 UPK3A UPK3A MYC MYC RASSF1 RASSF1 MMP9 MMP9 SRC SRC MAPK1 MAPK1 RB1 RB1 CSDE1 CSDE1 KRAS KRAS E2F1 E2F1 NRAS NRAS HRAS HRAS BRAF BRAF VEGFA VEGFA DAPK2 DAPK2 MAP2K1 MAP2K1 TP53 TP53 RAF1 RAF1 THBS1 THBS1 LOC110586222 LOC110586222 LOC110586384 LOC110586384 MMP20 MMP20 E2F3 E2F3 MAPK3 MAPK3 HBEGF HBEGF CXCL8 CXCL8 EGFR EGFR ERBB2 ERBB2 MMP2 MMP2 MAP2K2 MAP2K2 CDH1 CDH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
LOC110593709LOW QUALITY PROTEIN: cadherin-1-like. (506 aa)
DAPK1Death-associated protein kinase 1. (1370 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
ERASGTPase ERas. (233 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
E2F2Transcription factor E2F2. (449 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
UPK3AUroplakin-3a isoform X1. (287 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (340 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
SRCTyrosine-protein kinase. (536 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RB1Retinoblastoma-associated protein. (934 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
DAPK2Death-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (365 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
THBS1Thrombospondin-1. (1170 aa)
LOC110586222Interstitial collagenase-like. (466 aa)
LOC110586384LOW QUALITY PROTEIN: interstitial collagenase-like. (464 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
MMP272 kDa type IV collagenase. (661 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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