STRINGSTRING
BAX BAX NFKB1 NFKB1 IKBKB IKBKB LOC110573273 LOC110573273 GRB2 GRB2 AKT3 AKT3 IKBKG IKBKG LOC110573272 LOC110573272 PIK3R2 PIK3R2 SHC1 SHC1 E2F2 E2F2 LOC110575329 LOC110575329 BAK1 BAK1 CDKN1A CDKN1A DDB2 DDB2 RELA RELA HDAC1 HDAC1 PIK3R3 PIK3R3 PIK3CD PIK3CD SMAD4 SMAD4 PPP1R14B PPP1R14B BAD BAD CDKN1C CDKN1C CDK4 CDK4 CCND1 CCND1 BCR BCR CRKL CRKL MYC MYC MAPK1 MAPK1 RB1 RB1 LOC110579958 LOC110579958 CDK6 CDK6 CSDE1 CSDE1 KRAS KRAS LOC110579526 LOC110579526 ABL1 ABL1 BCL2L1 BCL2L1 E2F1 E2F1 NRAS NRAS HRAS HRAS PIK3CA PIK3CA BRAF BRAF CDKN1B CDKN1B CEP152 CEP152 SHC4 SHC4 TGFBR1 TGFBR1 MAP2K1 MAP2K1 GADD45G GADD45G SHC3 SHC3 TP53 TP53 RAF1 RAF1 SMAD3 SMAD3 HDAC2 HDAC2 NFKBIA NFKBIA POLK POLK CBL CBL PTPN11 PTPN11 E2F3 E2F3 SOS1 SOS1 CHUK CHUK TGFB2 TGFB2 MAPK3 MAPK3 TGFB1 TGFB1 SOS2 SOS2 PIK3R1 PIK3R1 AKT2 AKT2 MECOM MECOM GAB2 GAB2 MAP2K2 MAP2K2 SHC2 SHC2 CTBP2 CTBP2 CRK CRK GADD45B GADD45B MDM2 MDM2 ERAS ERAS CTBP1 CTBP1 LOC110570078 LOC110570078 TGFB3 TGFB3 RUNX1 RUNX1 PIK3CB PIK3CB GADD45A GADD45A TGFBR2 TGFBR2 ARAF ARAF AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXApoptosis regulator BAX isoform X1. (192 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
E2F2Transcription factor E2F2. (449 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
DDB2DNA damage-binding protein 2. (412 aa)
RELATranscription factor p65. (531 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (263 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BCRBreakpoint cluster region protein isoform X1. (1282 aa)
CRKLCrk-like protein. (303 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RB1Retinoblastoma-associated protein. (934 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
ABL1Tyrosine-protein kinase. (1137 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
E2F1LOW QUALITY PROTEIN: transcription factor E2F1. (483 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma isoform X1. (175 aa)
SHC3SHC-transforming protein 3. (469 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
POLKDNA polymerase kappa. (826 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
E2F3Transcription factor E2F3 isoform X1. (466 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MECOMMDS1 and EVI1 complex locus protein EVI1. (1238 aa)
GAB2GRB2-associated-binding protein 2. (678 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (551 aa)
CTBP2C-terminal-binding protein 2 isoform X1. (979 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
ERASGTPase ERas. (233 aa)
CTBP1C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
LOC110570078Runt-related transcription factor 1. (284 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
RUNX1Runt-related transcription factor 1. (193 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.