STRINGSTRING
KIT KIT NFKB1 NFKB1 CCNA2 CCNA2 IKBKB IKBKB BCL2A1 BCL2A1 LOC110573273 LOC110573273 JUP JUP GRB2 GRB2 AKT3 AKT3 IKBKG IKBKG LOC110573272 LOC110573272 SPIB SPIB EIF4EBP1 EIF4EBP1 CCNA1 CCNA1 PIK3R2 PIK3R2 STAT3 STAT3 PIM1 PIM1 PPARD PPARD SPI1 SPI1 RELA RELA RPS6KB2 RPS6KB2 MTOR MTOR PIK3R3 PIK3R3 LEF1 LEF1 PIK3CD PIK3CD PPP1R14B PPP1R14B BAD BAD DUSP6 DUSP6 CCND1 CCND1 LOC110578553 LOC110578553 RUNX1T1 RUNX1T1 MYC MYC MAPK1 MAPK1 LOC110579958 LOC110579958 CSDE1 CSDE1 KRAS KRAS LOC110579526 LOC110579526 NRAS NRAS HRAS HRAS PIK3CA PIK3CA BRAF BRAF MAP2K1 MAP2K1 RAF1 RAF1 PML PML ZBTB16 ZBTB16 CEBPE CEBPE SOS1 SOS1 TCF7L1 TCF7L1 CHUK CHUK TCF7L2 TCF7L2 MAPK3 MAPK3 CSF1R CSF1R CEBPA CEBPA SOS2 SOS2 AKT1 AKT1 CD14 CD14 CSF2 CSF2 PIK3R1 PIK3R1 ITGAM ITGAM AKT2 AKT2 TCF7 TCF7 RARA RARA MPO MPO LOC110570078 LOC110570078 RUNX1 RUNX1 LOC110591202 LOC110591202 MAP2K2 MAP2K2 RPS6KB1 RPS6KB1 FLT3 FLT3 PER2 PER2 ERAS ERAS PIK3CB PIK3CB PIM2 PIM2 ARAF ARAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
BCL2A1Bcl-2-related protein A1. (210 aa)
LOC110573273Signal transducer and activator of transcription 5B. (600 aa)
JUPJunction plakoglobin. (744 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
LOC110573272Signal transducer and activator of transcription 5A. (478 aa)
SPIBTranscription factor Spi-B. (262 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (320 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
SPI1Transcription factor PU.1 isoform X1. (271 aa)
RELATranscription factor p65. (531 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PPP1R14BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (203 aa)
BADBcl2-associated agonist of cell death isoform X1. (205 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC110578553High affinity immunoglobulin gamma Fc receptor I-like. (350 aa)
RUNX1T1LOW QUALITY PROTEIN: protein CBFA2T1. (663 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110579958Signal transducer and activator of transcription 5B-like. (204 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
LOC110579526Signal transducer and activator of transcription 5A-like. (153 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRAFSerine/threonine-protein kinase B-raf. (764 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
PMLProtein PML isoform X1. (880 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
TCF7L1Transcription factor 7-like 1. (463 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
TCF7L2Transcription factor 7-like 2. (446 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
CEBPACCAAT/enhancer-binding protein alpha. (356 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ITGAMLOW QUALITY PROTEIN: integrin alpha-M; Belongs to the integrin alpha chain family. (1154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TCF7Transcription factor 7. (419 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
MPOMyeloperoxidase. (718 aa)
LOC110570078Runt-related transcription factor 1. (284 aa)
RUNX1Runt-related transcription factor 1. (193 aa)
LOC110591202Interleukin-3-like. (143 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PER2Period circadian protein homolog 2. (1277 aa)
ERASGTPase ERas. (233 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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