STRINGSTRING
PDGFD PDGFD PIP5K1C PIP5K1C PCYT1B PCYT1B SLC44A2 SLC44A2 RPS6KB1 RPS6KB1 PLPP2 PLPP2 RHEBL1 RHEBL1 MAP2K2 MAP2K2 DGKE DGKE SLC22A4 SLC22A4 EGFR EGFR HIF1A HIF1A PDGFRA PDGFRA AKT2 AKT2 PLD1 PLD1 LOC110591392 LOC110591392 PLPP1 PLPP1 LOC110591391 LOC110591391 PIK3R1 PIK3R1 SLC22A5 SLC22A5 SOS2 SOS2 MAPK3 MAPK3 MAPK8 MAPK8 DGKH DGKH SOS1 SOS1 PDGFC PDGFC TSC2 TSC2 PDPK1 PDPK1 PLA2G4E PLA2G4E SLC44A4 SLC44A4 PDGFRB PDGFRB PLD2 PLD2 PLA2G4D PLA2G4D PLA2G4B PLA2G4B PLA2G4F PLA2G4F JMJD7 JMJD7 WASF1 WASF1 RAF1 RAF1 RHEB RHEB DGKG DGKG PIP5K1B PIP5K1B PCYT1A PCYT1A MAP2K1 MAP2K1 SLC22A2 SLC22A2 SLC22A3 SLC22A3 SLC22A1 SLC22A1 DGKI DGKI PIK3CA PIK3CA HRAS HRAS NRAS NRAS TSC1 TSC1 RALGDS RALGDS DGKB DGKB SLC44A1 SLC44A1 KRAS KRAS CSDE1 CSDE1 SLC44A3 SLC44A3 MAPK9 MAPK9 PDGFB PDGFB CHPT1 CHPT1 MAPK1 MAPK1 RAC2 RAC2 GPCPD1 GPCPD1 PLCG1 PLCG1 PRKCB PRKCB SP1 SP1 LYPLA1 LYPLA1 PIP5K1A PIP5K1A CHKB CHKB DGKA DGKA CHKA CHKA PIK3CD PIK3CD PIK3R3 PIK3R3 MTOR MTOR DGKZ DGKZ RPS6KB2 RPS6KB2 EGF EGF PLPP3 PLPP3 WASF2 WASF2 PRKCG PRKCG JUN JUN PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 PLA2G4A PLA2G4A AKT3 AKT3 GRB2 GRB2 AKT1 AKT1 RAC3 RAC3 SLC5A7 SLC5A7 RAC1 RAC1 PDGFA PDGFA PIK3CB PIK3CB FOS FOS SLC44A5 SLC44A5 DGKK DGKK WAS WAS PRKCA PRKCA WASF3 WASF3 ERAS ERAS DGKD DGKD DGKQ DGKQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFDPlatelet-derived growth factor D. (335 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (701 aa)
PCYT1BCholine-phosphate cytidylyltransferase B. (369 aa)
SLC44A2Choline transporter-like protein 2 isoform X1; Belongs to the CTL (choline transporter-like) family. (711 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PLPP2Phospholipid phosphatase 2 isoform X1. (288 aa)
RHEBL1GTPase RhebL1. (183 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
DGKEDiacylglycerol kinase. (572 aa)
SLC22A4Solute carrier family 22 member 4. (553 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLD1Phospholipase. (1040 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
PLPP1Phospholipid phosphatase 1 isoform X1. (285 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
SLC22A5Solute carrier family 22 member 5. (557 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1338 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DGKHDiacylglycerol kinase. (1220 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
TSC2Tuberin isoform X1. (1789 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (571 aa)
PLA2G4EPhospholipase A2. (841 aa)
SLC44A4Choline transporter-like protein 4 isoform X1; Belongs to the CTL (choline transporter-like) family. (709 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
PLD2Phospholipase. (933 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLA2G4BPhospholipase A2. (782 aa)
PLA2G4FPhospholipase A2. (860 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RHEBGTP-binding protein Rheb. (184 aa)
DGKGDiacylglycerol kinase. (790 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
PCYT1ACholine-phosphate cytidylyltransferase A. (367 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SLC22A2Solute carrier family 22 member 2 isoform X1. (554 aa)
SLC22A3Solute carrier family 22 member 3. (550 aa)
SLC22A1LOW QUALITY PROTEIN: solute carrier family 22 member 1. (554 aa)
DGKIDiacylglycerol kinase. (1058 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X1. (189 aa)
NRASGTPase NRas. (189 aa)
TSC1Hamartin. (1168 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (886 aa)
DGKBDiacylglycerol kinase. (803 aa)
SLC44A1Choline transporter-like protein 1 isoform X1; Belongs to the CTL (choline transporter-like) family. (719 aa)
KRASGTPase KRas. (188 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
SLC44A3Choline transporter-like protein 3; Belongs to the CTL (choline transporter-like) family. (606 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CHPT1Cholinephosphotransferase 1 isoform X1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (406 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GPCPD1. (673 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (634 aa)
SP1Transcription factor Sp1. (786 aa)
LYPLA1Acyl-protein thioesterase 1. (230 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
CHKBCholine/ethanolamine kinase. (395 aa)
DGKADiacylglycerol kinase. (733 aa)
CHKACholine kinase alpha. (410 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
DGKZDiacylglycerol kinase. (1130 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (499 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PLA2G4APhospholipase A2. (733 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (195 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
SLC44A5Choline transporter-like protein 5; Belongs to the CTL (choline transporter-like) family. (731 aa)
DGKKDiacylglycerol kinase. (1098 aa)
WASwiskott-Aldrich syndrome protein. (410 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
WASF3wiskott-Aldrich syndrome protein family member 3. (502 aa)
ERASGTPase ERas. (233 aa)
DGKDDiacylglycerol kinase. (1111 aa)
DGKQDiacylglycerol kinase. (945 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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