STRINGSTRING
NFATC3 NFATC3 RPS6KB1 RPS6KB1 MAP2K2 MAP2K2 EGFR EGFR LOC110591311 LOC110591311 HIF1A HIF1A TICAM2 TICAM2 AKT2 AKT2 CD28 CD28 STAT1 STAT1 NFKBIB NFKBIB RAF1 RAF1 IFNGR1 IFNGR1 LOC110585438 LOC110585438 CD3E CD3E PRKCQ PRKCQ LY6G5B LY6G5B LOC110584772 LOC110584772 NFKBIA NFKBIA ALK ALK RASGRP1 RASGRP1 LTK LTK EML4 EML4 PTEN PTEN PTPN11 PTPN11 CD3D CD3D TIRAP TIRAP CD3G CD3G TLR2 TLR2 PPP3CC PPP3CC CSNK2B CSNK2B CHUK CHUK LAT LAT MAPK3 MAPK3 LOC110588386 LOC110588386 LOC110590429 LOC110590429 PPP3R1 PPP3R1 PPP3CB PPP3CB PIK3R1 PIK3R1 MYD88 MYD88 LOC110570219 LOC110570219 MAP3K3 MAP3K3 MAP2K6 MAP2K6 IFNG IFNG IFNGR2 IFNGR2 ERAS ERAS LOC110570943 LOC110570943 FOS FOS PIK3CB PIK3CB LOC110570944 LOC110570944 PPP3CA PPP3CA BATF BATF AKT1 AKT1 JAK1 JAK1 NFKB1 NFKB1 IKBKB IKBKB BATF3 BATF3 AKT3 AKT3 IKBKG IKBKG PIK3R2 PIK3R2 STAT3 STAT3 JUN JUN LOC110575329 LOC110575329 CD247 CD247 EGF EGF MAPK13 MAPK13 MAPK14 MAPK14 RELA RELA BATF2 BATF2 RPS6KB2 RPS6KB2 MTOR MTOR PIK3R3 PIK3R3 NFATC2 NFATC2 PIK3CD PIK3CD TRAF6 TRAF6 NFATC1 NFATC1 MAPK12 MAPK12 PLCG1 PLCG1 CSNK2A1 CSNK2A1 MAPK11 MAPK11 MAPK1 MAPK1 CSDE1 CSDE1 KRAS KRAS CD4 CD4 PPP3R2 PPP3R2 TLR4 TLR4 NRAS NRAS HRAS HRAS PIK3CA PIK3CA PTPN6 PTPN6 NFKBIE NFKBIE MAP2K1 MAP2K1 CD274 CD274 MAP2K3 MAP2K3 JAK2 JAK2 CSNK2A2 CSNK2A2 TICAM1 TICAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
LOC110591311Transmembrane emp24 domain-containing protein 7. (224 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
TICAM2TIR domain-containing adapter molecule 2. (238 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CD28T-cell-specific surface glycoprotein CD28. (221 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X1. (354 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
IFNGR1LOW QUALITY PROTEIN: interferon gamma receptor 1. (474 aa)
LOC110585438Uncharacterized protein LOC110585438. (271 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
LOC110584772Toll-like receptor 9 isoform X1. (1328 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
ALKTyrosine-protein kinase receptor. (1606 aa)
RASGRP1RAS guanyl-releasing protein 1. (956 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. (834 aa)
EML4Echinoderm microtubule-associated protein-like 4. (987 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (223 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (182 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
LATLinker for activation of T-cells family member 1. (256 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC110588386LOW QUALITY PROTEIN: toll-like receptor 2. (348 aa)
LOC110590429Tyrosine-protein kinase. (616 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
LOC110570219Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (470 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (626 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IFNGR2Interferon gamma receptor 2 isoform X1. (356 aa)
ERASGTPase ERas. (233 aa)
LOC110570943Programmed cell death protein 1-like. (235 aa)
FOSProto-oncogene c-Fos. (380 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC110570944Programmed cell death protein 1-like. (204 aa)
PPP3CASerine/threonine-protein phosphatase. (526 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
JAK1Tyrosine-protein kinase. (1156 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3. (125 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
LOC110575329Tyrosine-protein phosphatase non-receptor type 11-like. (582 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (182 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1197 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RELATranscription factor p65. (531 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (275 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
MTORSerine/threonine-protein kinase mTOR. (2557 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (920 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (891 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (398 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
KRASGTPase KRas. (188 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
NRASGTPase NRas. (189 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CD274Programmed cell death 1 ligand 1. (260 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
CSNK2A2Casein kinase II subunit alpha. (213 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (767 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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