STRINGSTRING
ITGA2 ITGA2 ITGA6 ITGA6 ADCY1 ADCY1 DES DES ADCY6 ADCY6 ADCY7 ADCY7 ITGA4 ITGA4 ACTBL2 ACTBL2 CACNB1 CACNB1 SGCA SGCA ITGA3 ITGA3 LRRC66 LRRC66 CACNB4 CACNB4 ITGB6 ITGB6 ADCY2 ADCY2 ATP2A1 ATP2A1 SGCB SGCB TGFB1 TGFB1 CACNB3 CACNB3 ATP2A3 ATP2A3 ITGAV ITGAV PRKACA PRKACA GNAS GNAS DMD DMD LOC110569839 LOC110569839 SGCG SGCG ITGB3 ITGB3 CACNG1 CACNG1 CACNG4 CACNG4 ITGA9 ITGA9 CACNA1F CACNA1F TGFB3 TGFB3 CACNG5 CACNG5 SLC8A3 SLC8A3 ACTB ACTB ITGA2B ITGA2B LMNA LMNA TPM3 TPM3 TNNT1 TNNT1 SLC8A2 SLC8A2 CACNG6 CACNG6 ITGB4 ITGB4 TNNI3 TNNI3 ACTG1 ACTG1 TNNT2 TNNT2 TPM4 TPM4 CACNG7 CACNG7 CACNG8 CACNG8 CACNA1S CACNA1S ACTL8 ACTL8 MYBPC3 MYBPC3 TNNT3 TNNT3 ITGB1 ITGB1 LAMA1 LAMA1 CACNG3 CACNG3 DAG1 DAG1 CACNA2D2 CACNA2D2 CACNG2 CACNG2 ITGA10 ITGA10 ITGB7 ITGB7 ITGA7 ITGA7 ITGA5 ITGA5 LOC110579361 LOC110579361 LOC110579416 LOC110579416 EMD EMD IGF1 IGF1 ITGB8 ITGB8 CACNA2D4 CACNA2D4 CACNA1C CACNA1C ADCY8 ADCY8 TPM2 TPM2 CACNA2D1 CACNA2D1 LOC110581854 LOC110581854 ITGB5 ITGB5 ADCY5 ADCY5 PRKACB PRKACB LAMA2 LAMA2 PLN PLN LOC110583555 LOC110583555 TPM1 TPM1 LOC110581756 LOC110581756 LOC110584476 LOC110584476 LOC110584475 LOC110584475 LOC110584711 LOC110584711 CACNA1D CACNA1D LOC110584712 LOC110584712 CACNA2D3 CACNA2D3 MYH15 MYH15 LOC110582926 LOC110582926 TNNC1 TNNC1 LOC110585145 LOC110585145 LOC110585144 LOC110585144 UTRN UTRN ADCY4 ADCY4 ITGA11 ITGA11 RYR2 RYR2 AGT AGT ITGA8 ITGA8 SLC39A12 SLC39A12 TNF TNF LOC110584677 LOC110584677 SGCD SGCD ADCY3 ADCY3 ITGA1 ITGA1 SLC8A1 SLC8A1 ATP2A2 ATP2A2 CACNB2 CACNB2 PTRHD1 PTRHD1 ADCY9 ADCY9 TGFB2 TGFB2 MYL2 MYL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1105 aa)
ITGA6Integrin alpha-6 isoform X2; Belongs to the integrin alpha chain family. (1073 aa)
ADCY1Adenylate cyclase type 1. (921 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ITGA4LOW QUALITY PROTEIN: integrin alpha-4; Belongs to the integrin alpha chain family. (1039 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (598 aa)
SGCALOW QUALITY PROTEIN: alpha-sarcoglycan. (386 aa)
ITGA3LOW QUALITY PROTEIN: integrin alpha-3; Belongs to the integrin alpha chain family. (1050 aa)
LRRC66Leucine-rich repeat-containing protein 66. (1020 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1088 aa)
SGCBBeta-sarcoglycan. (376 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1038 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1047 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1003 aa)
DMDDystrophin isoform X1. (3680 aa)
LOC110569839Neuroendocrine secretory protein 55. (246 aa)
SGCGGamma-sarcoglycan. (309 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ITGA9Integrin alpha-9; Belongs to the integrin alpha chain family. (934 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (668 aa)
LMNALamin; Belongs to the intermediate filament family. (666 aa)
TPM3Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (285 aa)
TNNT1Troponin T, slow skeletal muscle. (227 aa)
SLC8A2Sodium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit. (153 aa)
ITGB4Integrin beta. (800 aa)
TNNI3Troponin I, cardiac muscle isoform X1. (211 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
TNNT2Troponin T, cardiac muscle isoform X1. (484 aa)
TPM4Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit. (267 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
MYBPC3Myosin-binding protein C, cardiac-type. (1270 aa)
TNNT3Troponin T, fast skeletal muscle isoform X1. (258 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LAMA1LOW QUALITY PROTEIN: laminin subunit alpha-1. (3077 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
DAG1Dystroglycan. (891 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1. (1081 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ITGA10Integrin alpha-10 isoform X1; Belongs to the integrin alpha chain family. (1162 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (882 aa)
ITGA7Integrin alpha-7 isoform X1; Belongs to the integrin alpha chain family. (1181 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
LOC110579361Myosin-1-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (127 aa)
LOC110579416Integrin alpha-IIb-like. (222 aa)
EMDEmerin. (260 aa)
IGF1Insulin-like growth factor I isoform X1. (185 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1121 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2191 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
TPM2Tropomyosin beta chain isoform X1; Belongs to the tropomyosin family. (284 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2. (1110 aa)
LOC110581854Integrin beta-4-like. (1125 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1205 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LAMA2Laminin subunit alpha-2. (3088 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
LOC110583555Myosin-3-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (291 aa)
TPM1Tropomyosin alpha-1 chain isoform X4; Belongs to the tropomyosin family. (284 aa)
LOC110581756Integrin beta-4-like. (1070 aa)
LOC110584476LOW QUALITY PROTEIN: myosin heavy chain, skeletal muscle-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1150 aa)
LOC110584475Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1435 aa)
LOC110584711Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
LOC110584712Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3. (1091 aa)
MYH15LOW QUALITY PROTEIN: myosin-15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2025 aa)
LOC110582926Voltage-dependent calcium channel gamma-6 subunit-like. (155 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
LOC110585145Myosin-7-like isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1945 aa)
LOC110585144Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
UTRNUtrophin. (3366 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITGA11Integrin alpha-11; Belongs to the integrin alpha chain family. (1238 aa)
RYR2Ryanodine receptor 2. (5000 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1066 aa)
SLC39A12LOW QUALITY PROTEIN: zinc transporter ZIP12. (693 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC110584677Myosin-8 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
SGCDDelta-sarcoglycan. (289 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (1289 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (965 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (661 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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