STRINGSTRING
IKBKB IKBKB PLAT PLAT NFKB1 NFKB1 BMPR1B BMPR1B IL1R2 IL1R2 AKT1 AKT1 LOC110572425 LOC110572425 RAC3 RAC3 RAC1 RAC1 PDGFA PDGFA HSP90AA1 HSP90AA1 CALM1 CALM1 PIK3CB PIK3CB FOS FOS LOC110571316 LOC110571316 MGST2 MGST2 SUMO3 SUMO3 LOC110569944 LOC110569944 GPC1 GPC1 LOC110570785 LOC110570785 LOC110570615 LOC110570615 IFNG IFNG MAP2K6 MAP2K6 PECAM1 PECAM1 CTNNB1 CTNNB1 ITGB3 ITGB3 LOC110569942 LOC110569942 LOC110569925 LOC110569925 MAP2K7 MAP2K7 KEAP1 KEAP1 LOC110582186 LOC110582186 GSTA4 GSTA4 LOC110582041 LOC110582041 HSP90AB1 HSP90AB1 LOC110582011 LOC110582011 TXNDC2 TXNDC2 ASS1 ASS1 LOC110581360 LOC110581360 SDC4 SDC4 TNFRSF1A TNFRSF1A MGST1 MGST1 PTK2 PTK2 NPPC NPPC LOC110579149 LOC110579149 ACTB ACTB LOC110578389 LOC110578389 LOC110580360 LOC110580360 MAPK9 MAPK9 PDGFB PDGFB LOC110578390 LOC110578390 MAPK11 MAPK11 SRC SRC MMP9 MMP9 RAC2 RAC2 TXN2 TXN2 HMOX1 HMOX1 LOC110579416 LOC110579416 LOC110578745 LOC110578745 SDC2 SDC2 LOC110578394 LOC110578394 MAPK12 MAPK12 LOC110578391 LOC110578391 HSP90B1 HSP90B1 NOX1 NOX1 BCL2 BCL2 PIK3CD PIK3CD PIK3R3 PIK3R3 LOC110574722 LOC110574722 LOC110576049 LOC110576049 LOC110576050 LOC110576050 RELA RELA ACTL8 ACTL8 MAPK14 MAPK14 PRKCZ PRKCZ MAPK13 MAPK13 CALML6 CALML6 PRKAA2 PRKAA2 JUN JUN ARHGEF2 ARHGEF2 PIK3R2 PIK3R2 KLF2 KLF2 IKBKG IKBKG AKT3 AKT3 MEF2A MEF2A NCF2 NCF2 SELE SELE ACTG1 ACTG1 SUMO2 SUMO2 IL1R1 IL1R1 ITGA2B ITGA2B ACVR2B ACVR2B TRPV4 TRPV4 ITGAV ITGAV CDH5 CDH5 LOC110594239 LOC110594239 NQO1 NQO1 ICAM1 ICAM1 PIAS4 PIAS4 LOC110591514 LOC110591514 MMP2 MMP2 ACTBL2 ACTBL2 ACVR1 ACVR1 LOC110592974 LOC110592974 BMP4 BMP4 NFE2L2 NFE2L2 LOC110592210 LOC110592210 AKT2 AKT2 SUMO1 SUMO1 LOC110592156 LOC110592156 BMPR2 BMPR2 NCF1 NCF1 LOC110589552 LOC110589552 THBD THBD LOC110591392 LOC110591392 LOC110591391 LOC110591391 PIK3R1 PIK3R1 LOC110589699 LOC110589699 KDR KDR MGST3 MGST3 MAPK8 MAPK8 GSTO1 GSTO1 BMPR1A BMPR1A CHUK CHUK CAV2 CAV2 MEF2C MEF2C CAV1 CAV1 IL1A IL1A MMP20 MMP20 LOC110588206 LOC110588206 SDC1 SDC1 IL1B IL1B CAV3 CAV3 EDN1 EDN1 TNF TNF LOC110586587 LOC110586587 MAP2K4 MAP2K4 CALML5 CALML5 LOC110586280 LOC110586280 PRKAA1 PRKAA1 CALML4 CALML4 MAP2K5 MAP2K5 MAPK7 MAPK7 TP53 TP53 TXNDC8 TXNDC8 VEGFA VEGFA MAP3K7 MAP3K7 LOC110583436 LOC110583436 NOXA1 NOXA1 MAP3K5 MAP3K5 NOS3 NOS3 VCAM1 VCAM1 LOC110580326 LOC110580326 SQSTM1 SQSTM1 PIK3CA PIK3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X4. (987 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IL1R2Interleukin-1 receptor type 2 isoform X1. (418 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC110572425Parvalbumin beta-like. (129 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (195 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (331 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PIK3CBLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
LOC110571316Small ubiquitin-related modifier. (95 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
SUMO3Small ubiquitin-related modifier. (111 aa)
LOC110569944Cathepsin L1-like; Belongs to the peptidase C1 family. (333 aa)
GPC1Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
LOC110570785Small ubiquitin-related modifier 2-like. (76 aa)
LOC110570615Glutathione S-transferase P-like; Belongs to the GST superfamily. (180 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (741 aa)
CTNNB1Catenin beta-1. (781 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
LOC110569942Cathepsin L1-like isoform X1; Belongs to the peptidase C1 family. (335 aa)
LOC110569925Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (440 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
LOC110582186Glutathione S-transferase. (223 aa)
GSTA4Glutathione S-transferase A4; Belongs to the GST superfamily. (222 aa)
LOC110582041Glutathione S-transferase. (246 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
LOC110582011Glutathione S-transferase 3-like. (93 aa)
TXNDC2Thioredoxin domain-containing protein 2. (560 aa)
ASS1Argininosuccinate synthase. (412 aa)
LOC110581360Thioredoxin; Belongs to the thioredoxin family. (105 aa)
SDC4Syndecan-4 isoform X1. (200 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
MGST1Microsomal glutathione S-transferase 1 isoform X1. (164 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)
NPPCC-type natriuretic peptide. (126 aa)
LOC110579149Small ubiquitin-related modifier 2-like. (70 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC110578389Glutathione S-transferase theta-3-like; Belongs to the GST superfamily. (240 aa)
LOC110580360Glutathione S-transferase. (226 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC110578390Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (242 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SRCTyrosine-protein kinase. (536 aa)
MMP9Matrix metalloproteinase-9 isoform X1. (704 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
TXN2Thioredoxin, mitochondrial. (163 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
LOC110579416Integrin alpha-IIb-like. (222 aa)
LOC110578745Small ubiquitin-related modifier 2-like. (87 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
LOC110578394LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like; Belongs to the GST superfamily. (243 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC110578391Glutathione S-transferase theta-4; Belongs to the GST superfamily. (241 aa)
HSP90B1LOW QUALITY PROTEIN: endoplasmin. (804 aa)
NOX1NADPH oxidase 1. (572 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (234 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
LOC110574722Thioredoxin-like. (68 aa)
LOC110576049Glutathione S-transferase P-like. (210 aa)
LOC110576050Glutathione S-transferase P; Belongs to the GST superfamily. (210 aa)
RELATranscription factor p65. (531 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALML6Calmodulin-like protein 6. (232 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (964 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X1. (726 aa)
KLF2Krueppel-like factor 2. (357 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MEF2ALOW QUALITY PROTEIN: myocyte-specific enhancer factor 2A. (486 aa)
NCF2Neutrophil cytosol factor 2. (526 aa)
SELEE-selectin. (609 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
IL1R1LOW QUALITY PROTEIN: interleukin-1 receptor type 1. (595 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (668 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (892 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1047 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
LOC110594239Small ubiquitin-related modifier. (101 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1. (273 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
PIAS4E3 SUMO-protein ligase PIAS4 isoform X1. (513 aa)
LOC110591514Cytochrome b-245 light chain. (190 aa)
MMP272 kDa type IV collagenase. (661 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOC110592974C-C motif chemokine. (101 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (456 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (606 aa)
LOC110592210Calmodulin-like; Belongs to the calmodulin family. (149 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
LOC110592156Calmodulin-like; Belongs to the calmodulin family. (98 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (944 aa)
NCF1Neutrophil cytosol factor 1 isoform X1. (391 aa)
LOC110589552Small ubiquitin-related modifier 1-like. (54 aa)
THBDThrombomodulin. (668 aa)
LOC110591392Mitogen-activated protein kinase. (300 aa)
LOC110591391Mitogen-activated protein kinase 10-like. (176 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC110589699Glutathione S-transferase omega-2 isoform X1; Belongs to the GST superfamily. (216 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GSTO1Glutathione S-transferase omega-1; Belongs to the GST superfamily. (241 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
MEF2CMyocyte-specific enhancer factor 2C. (463 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
LOC110588206Small ubiquitin-related modifier. (95 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (307 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
EDN1Endothelin-1. (202 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC110586587Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC110586280Small ubiquitin-related modifier 2-like. (76 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TXNDC8Thioredoxin domain-containing protein 8. (91 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (549 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC110583436Cathepsin L1-like; Belongs to the peptidase C1 family. (218 aa)
NOXA1NADPH oxidase activator 1. (466 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
VCAM1Vascular cell adhesion protein 1. (776 aa)
LOC110580326Glutathione S-transferase Mu 1-like. (218 aa)
SQSTM1Sequestosome-1. (439 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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