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rfaB rfaB ptsP ptsP uppS uppS cdsA cdsA rseP rseP yaeT yaeT hlpA hlpA lpxD lpxD fabZ fabZ lpxA lpxA lpxB lpxB gmhB gmhB lpxH lpxH lpxC lpxC yggB yggB yfiC yfiC vacJ vacJ PAU_01585 PAU_01585 msbB msbB kdsA kdsA htrB htrB ompA ompA kdsB kdsB lpxK lpxK ybhK ybhK gmhA gmhA waaQ waaQ hldE hldE rsmI rsmI PAU_03639 PAU_03639 diaA diaA yraP yraP PAU_03668 PAU_03668 PAU_03669 PAU_03669 PAU_03670 PAU_03670 PAU_03671 PAU_03671 yrbF yrbF yrbG yrbG kdsD kdsD kdsC kdsC lptC lptC yhbN yhbN yhbG yhbG yhbH yhbH ptsN ptsN rapZ rapZ ptsO ptsO rnk rnk PAU_03685 PAU_03685 yjgQ yjgQ yjgP yjgP yhbQ yhbQ hldD hldD rfaF rfaF rfaC rfaC walV walV PAU_04357 PAU_04357 rfaG rfaG walW walW kdtA kdtA kdtX kdtX rfaL rfaL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfaBLipopolysaccharide 1,6-galactosyltransferase. (357 aa)
ptsPPhosphotransferase system, enzyme I, PtsP; Phosphoenolpyruvate-protein phosphotransferase pts (phosphotransferase system, enzyme i) (enzyme i-ntr); Belongs to the PEP-utilizing enzyme family. (748 aa)
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (282 aa)
rsePMetalloendopeptidase-protease ecfe. (451 aa)
yaeTOuter membrane protein assembly factor yaet precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (797 aa)
hlpAChaperone protein skp precursorlocated in outer membrane or nucleoid; Belongs to the skp family. (203 aa)
lpxDUdp-3-o-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (342 aa)
fabZ(3r)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (150 aa)
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
lpxBlipid-A-disaccharide synthase); Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (394 aa)
gmhBD,d-heptose 1,7-bisphosphate phosphatase 1. (205 aa)
lpxHUdp-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
yggBConserved hypothetical protein. (290 aa)
yfiCConserved hypothetical protein; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). (244 aa)
vacJVacj lipoprotein. (250 aa)
PAU_01585Putative LPS biosynthesis enzyme (lipopolysaccharide core biosynthesi protein rfaq). (365 aa)
msbBLipid A biosynthesis (kdo)2-(lauroyl)-lipid iva acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (292 aa)
htrBLipid a biosynthesis lauroyl acyltransferase (heat shock protein b); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (313 aa)
ompAOuter membrane protein a (outer membrane protein ii*); Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (366 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (331 aa)
ybhKConserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (302 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (193 aa)
waaQPutative heptosyl III transferase. (316 aa)
hldEBifunctional protein HldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
rsmIConserved hypothetical Protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (288 aa)
PAU_03639Conserved hypothetical Protein; Belongs to the UPF0102 family. (126 aa)
diaADnaa initiator-associating protein diaa. (196 aa)
yraPConserved hypothetical protein; Similar to unknown protein yrap of escherichia coli. (191 aa)
PAU_03668Conserved hypothetical Protein. (97 aa)
PAU_03669Conserved hypothetical Protein. (209 aa)
PAU_03670Conserved hypothetical Protein. (172 aa)
PAU_03671Conserved hypothetical Protein. (262 aa)
yrbFHypothetical abc transporter atp-binding protein yrbf. (267 aa)
yrbGSimilar to putative cation antiporter. (324 aa)
kdsDArabinose 5-phosphate isomerase). (322 aa)
kdsC3-deoxy-d-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (187 aa)
lptCHypothetical Protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (192 aa)
yhbNProtein yhbn precursor probable transporter; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (177 aa)
yhbGProbable abc transporter atp-binding protein yhbg. (241 aa)
yhbHProbable sigma(54) modulation protein (orf3) (orf95). (95 aa)
ptsNNitrogen regulatory iia protein (enzyme iia-ntr) (phosphotransferas enzyme ii, a component). (155 aa)
rapZConserved hypothetical Protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (283 aa)
ptsOPhosphocarrier protein npr (nitrogen related hpr). (90 aa)
rnkRegulator of nucleoside diphosphate kinase; May act as an anti-Gre factor; Belongs to the Rnk family. (136 aa)
PAU_03685Conserved hypothetical Protein. (99 aa)
yjgQSimilar to putative membrane protein yjgq of escherichia coli. (358 aa)
yjgPInner membrane protein yjgp. (366 aa)
yhbQConserved hypothetical protein; Belongs to the UPF0213 family. (103 aa)
hldDADP-L-glycero-d-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (324 aa)
rfaFadp-heptose--LPS heptosyltransferase II involved in lipopolysaccharid core biosynthesis. (350 aa)
rfaCLipopolysaccharide heptosyltransferase-1. (321 aa)
walVConserved hypothetical protein. (322 aa)
PAU_04357Putative LPS biosynthesis enzyme (lipopolysaccharide core biosynthesi protein rfaq). (354 aa)
rfaGLipopolysaccharide core biosynthesis protein rfag (glucosyltransferas i). (376 aa)
walWPutative glycosyltransferase. (370 aa)
kdtA3-deoxy-d-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
kdtXLipopolysaccharide core biosynthesis glycosyl transferase kdtx. (253 aa)
rfaLLipid a-core:surface polymer ligase. (408 aa)
Your Current Organism:
Photorhabdus asymbiotica
NCBI taxonomy Id: 291112
Other names: ATCC 43950, CIP 106331, DSM 15149, P. asymbiotica, strain 3265-86
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