node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fabZ | hlpA | BPEN_290 | BPEN_288 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | 0.723 |
fabZ | lpxA | BPEN_290 | BPEN_291 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.992 |
fabZ | lpxB | BPEN_290 | BPEN_292 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.884 |
fabZ | lpxC | BPEN_290 | BPEN_151 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.934 |
fabZ | lpxD | BPEN_290 | BPEN_289 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.858 |
fabZ | lpxK | BPEN_290 | BPEN_389 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.402 |
gutQ | kdsA | BPEN_474 | BPEN_361 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 3-deoxy-D-manno-octulosonic acid 8-P synthetase; Ortholog to Escherichia coli bnum: b1215; MultiFun: Cell structure 6.1, 6.2, 6.3, 6.7; Metabolism 1.6.5; Belongs to the KdsA family. | 0.898 |
gutQ | kdsB | BPEN_474 | BPEN_387 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.912 |
gutQ | kdtA | BPEN_474 | BPEN_633 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | Kdo transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.658 |
gutQ | lpxA | BPEN_474 | BPEN_291 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.497 |
gutQ | lpxC | BPEN_474 | BPEN_151 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.468 |
gutQ | lpxD | BPEN_474 | BPEN_289 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.620 |
gutQ | lpxK | BPEN_474 | BPEN_389 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.705 |
gutQ | lpxL | BPEN_474 | BPEN_423 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). | 0.555 |
hlpA | fabZ | BPEN_288 | BPEN_290 | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.723 |
hlpA | lpxA | BPEN_288 | BPEN_291 | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.670 |
hlpA | lpxB | BPEN_288 | BPEN_292 | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.581 |
hlpA | lpxD | BPEN_288 | BPEN_289 | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.943 |
kdsA | gutQ | BPEN_361 | BPEN_474 | 3-deoxy-D-manno-octulosonic acid 8-P synthetase; Ortholog to Escherichia coli bnum: b1215; MultiFun: Cell structure 6.1, 6.2, 6.3, 6.7; Metabolism 1.6.5; Belongs to the KdsA family. | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 0.898 |
kdsA | kdsB | BPEN_361 | BPEN_387 | 3-deoxy-D-manno-octulosonic acid 8-P synthetase; Ortholog to Escherichia coli bnum: b1215; MultiFun: Cell structure 6.1, 6.2, 6.3, 6.7; Metabolism 1.6.5; Belongs to the KdsA family. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.844 |