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| | yjgF | Putative translation initiation inhibitor; Ortholog to Escherichia coli bnum: b4243. (133 aa) |
| | argI | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (341 aa) |
| | pepA | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (503 aa) |
| | folB | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. (127 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (214 aa) |
| | metC | Beta-cystathionase; Ortholog to Escherichia coli bnum: b3008; MultiFun: Metabolism 1.5.1.9. (395 aa) |
| | cysQ | CysQ; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (251 aa) |
| | ispB | Octaprenyl-diphosphate synthase; Ortholog to Escherichia coli bnum: b3187; MultiFun: Metabolism 1.5.3.19; Belongs to the FPP/GGPP synthase family. (323 aa) |
| | folP | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (279 aa) |
| | thrA | Bifunctional; ortholog to Escherichia coli bnum: b0002; MultiFun: Metabolism 1.5.1.21, 1.5.1.8; homoserine dehydrogenase I, threonine sensitive; In the C-terminal section; belongs to the homoserine dehydrogenase family. (816 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa) |
| | thrC | Threonine synthase; Ortholog to Escherichia coli bnum: b0004; MultiFun: Metabolism 1.5.1.8. (433 aa) |
| | ribF | Bifunctional: flavokinase; Ortholog to Escherichia coli bnum: b0025; MultiFun: Metabolism 1.5.3.9; Belongs to the ribF family. (324 aa) |
| | ispH | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (311 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (282 aa) |
| | carA | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. (379 aa) |
| | carB | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. (1075 aa) |
| | folA | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa) |
| | leuD | 3-isopropylmalate dehydratase subunit 1; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa) |
| | leuC | 3-isopropylmalate dehydratase subunit 2; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (366 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (212 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2. (164 aa) |
| | cysJ | Sulfite reductase, alpha subunit (flavoprotein); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (606 aa) |
| | cysI | Sulfite reductase, beta subunit, NADPH-dependent hemoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (575 aa) |
| | cysH | 3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (253 aa) |
| | cysG | Multifunctional siroheme synthase: uroporphyrinogen methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (474 aa) |
| | cysD | ATP-sulfurylase, subunit 2; Ortholog to Escherichia coli bnum: b2752; MultiFun: Metabolism 1.8.2; ATP:sulfate adenylyltransferase. (304 aa) |
| | cysN | ATP-sulfurylase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (476 aa) |
| | cysC | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (211 aa) |
| | ispD | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (235 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase, tyr-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (361 aa) |
| | tyrA | Chorismate mutase T; Bifunctional; ortholog to Escherichia coli bnum: b2600; MultiFun: Metabolism 1.5.1.13, 1.5.1.14; prephenate dehydrogenase. (375 aa) |
| | pheA | Chorismate mutase P; Bifunctional; ortholog to Escherichia coli bnum: b2599; MultiFun: Metabolism 1.5.1.13, 1.5.1.14; prephenate dehydratase. (296 aa) |
| | birA | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). (271 aa) |
| | coaA | Pantothenate kinase; Ortholog to Escherichia coli bnum: b3974; MultiFun: Metabolism 1.5.3.5. (313 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (291 aa) |
| | ribD | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (379 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (158 aa) |
| | nusB | L factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (144 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (624 aa) |
| | ispA | Geranyltranstransferase; Ortholog to Escherichia coli bnum: b0421; MultiFun: Metabolism 1.5.3.19; Belongs to the FPP/GGPP synthase family. (306 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | speB | Agmatinase; Ortholog to Escherichia coli bnum: b2937; MultiFun: Metabolism 1.7.14; Belongs to the arginase family. (306 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (429 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Ortholog to Escherichia coli bnum: b0166; MultiFun: Metabolism 1.5.1.7; Belongs to the transferase hexapeptide repeat family. (283 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (397 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa) |
| | cysS | cysteinyl-tRNA synthetase; Ortholog to Escherichia coli bnum: b0526; MultiFun: Information transfer 2.3.1; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (295 aa) |
| | ribE | Riboflavin synthase, alpha chain; Ortholog to Escherichia coli bnum: b1662; MultiFun: Metabolism 1.5.3.9. (207 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (216 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase; Ortholog to Escherichia coli bnum: b1096; MultiFun: Metabolism 1.5.3.2. (273 aa) |
| | aspC | Aspartate aminotransferase; Ortholog to Escherichia coli bnum: b0928; MultiFun: Metabolism 1.1.3, 1.5.1.5. (401 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (199 aa) |
| | trpE | Anthranilate synthase component I; Ortholog to Escherichia coli bnum: b1264; MultiFun: Metabolism 1.5.1.15. (520 aa) |
| | trpG | Anthranilate synthase component II: glutamine amidotransferase; Ortholog to Escherichia coli bnum: b1263; MultiFun: Metabolism 1.5.1.15. (198 aa) |
| | trpD | Anthranilate synthase component II: anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | Indole-3-glycerolphosphate synthetase; Bifunctional; ortholog to Escherichia coli bnum: b1262; MultiFun: Metabolism 1.5.1.15; N-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpC family. (457 aa) |
| | trpB | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (276 aa) |
| | pabB | Component of p-aminobenzoate synthase multienzyme complex; ortholog to Escherichia coli bnum: b1812; MultiFun: Metabolism 1.5.3.2. (462 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa) |
| | hisD | L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Ortholog to Escherichia coli bnum: b2021; MultiFun: Metabolism 1.5.1.16; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa) |
| | hisB | Histidinol-phosphatase; Bifunctional; ortholog to Escherichia coli bnum: b2022; MultiFun: Metabolism 1.5.1.16; imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. (356 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide; Ortholog to Escherichia coli bnum: b2024; MultiFun: Metabolism 1.5.1.16. (246 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Bifunctional; ortholog to Escherichia coli bnum: b2026; MultiFun: Metabolism 1.5.1.16; phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (213 aa) |
| | folE | GTP cyclohydrolase I; Ortholog to Escherichia coli bnum: b2153; MultiFun: Metabolism 1.5.3.2. (221 aa) |
| | folC | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (424 aa) |
| | pdxB | Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (374 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | cysK | Cysteine synthase A; Ortholog to Escherichia coli bnum: b2414; MultiFun: Metabolism 1.5.1.12; Belongs to the cysteine synthase/cystathionine beta- synthase family. (315 aa) |
| | cysA | Sulfate permease A protein, chromate resistance (ABC superfamily, atp_bind); Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (355 aa) |
| | cysW | Thiosulfate permease W protein (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b2423; MultiFun: Cell structure 6.1; Metabolism 1.8.2; Transport 4.3.A.1.m, 4.S.178. (286 aa) |
| | cysU | Thiosulfate transport protein (ABC superfamily, membrane); Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa) |
| | cysP | Thiosulfate transport protein (ABC superfamily, peri_bind); Ortholog to Escherichia coli bnum: b2425; MultiFun: Metabolism 1.8.2; Transport 4.3.A.1.p, 4.S.178. (340 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (384 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (376 aa) |
| | yfgB | Putative pyruvate formate lyase activating enzyme 2; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (373 aa) |
| | suhB | Putative myo-inositol-1(or 4)-monophosphatase; Ortholog to Escherichia coli bnum: b2533; MultiFun: Information transfer 2.2.2; Regulation 3.1.3.2; Belongs to the inositol monophosphatase superfamily. (264 aa) |
| | tadA | tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (155 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa) |
| | pdxJ | Putative pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (244 aa) |
| | pabA | Aminodeoxychorismate synthase subunit II; Component of p-aminobenzoate synthase multienzyme complex; ortholog to Escherichia coli bnum: b3360; MultiFun: Metabolism 1.5.3.2. (193 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Ortholog to Escherichia coli bnum: b3433; MultiFun: Metabolism 1.5.1.21; Metabolism 1.5.1.7, 1.5.1.8, 1.5.1.9; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | yigB | Putative hydrolase of the HAD superfamily; Ortholog to Escherichia coli bnum: b3812. (238 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (300 aa) |
| | hemD | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (249 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | ilvA | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | ilvD | Dihydroxyacid dehydratase; Ortholog to Escherichia coli bnum: b3771; MultiFun: Metabolism 1.5.1.18; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | ilvM | Acetolactate synthase II, small subunit; Ortholog to Escherichia coli bnum: b3769; MultiFun: Metabolism 1.5.1.18. (78 aa) |
| | ilvG | Acetolactate synthase II, large subunit; Ortholog to Escherichia coli bnum: b3767; MultiFun: Metabolism 1.5.1.18; cryptic genes 10. (546 aa) |
| | metF | 5,10 methylenetetrahydrofolate reductase; Ortholog to Escherichia coli bnum: b3941; MultiFun: Metabolism 1.7.17; Belongs to the methylenetetrahydrofolate reductase family. (297 aa) |
| | metB | Cystathionine gamma-synthase; Ortholog to Escherichia coli bnum: b3939; MultiFun: Metabolism 1.1.3.7, 1.5.1.9, 1.7.30. (382 aa) |
| | cysE | Serine acetyltransferase; Ortholog to Escherichia coli bnum: b3607; MultiFun: Metabolism 1.5.1.12; Belongs to the transferase hexapeptide repeat family. (249 aa) |
| | coaD | CMP-deoxy-D-manno-octulosonate-lipid A transferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (171 aa) |
| | dfp | 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa) |
| | glnA | Glutamine synthetase; Ortholog to Escherichia coli bnum: b3870; MultiFun: Metabolism 1.5.1.2, 1.8.3. (474 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (304 aa) |
