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aroF aroF tyrA tyrA aroE aroE aroQ aroQ aroA aroA pabC pabC trpE trpE trpG trpG trpD trpD trpC trpC trpB trpB trpA trpA pabB pabB hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI aroC aroC pabA pabA aroB aroB aroK aroK
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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aroFPhospho-2-dehydro-3-deoxyheptonate aldolase, tyr-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (361 aa)
tyrAChorismate mutase T; Bifunctional; ortholog to Escherichia coli bnum: b2600; MultiFun: Metabolism 1.5.1.13, 1.5.1.14; prephenate dehydrogenase. (375 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (291 aa)
aroQ3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa)
pabC4-amino-4-deoxychorismate lyase; Ortholog to Escherichia coli bnum: b1096; MultiFun: Metabolism 1.5.3.2. (273 aa)
trpEAnthranilate synthase component I; Ortholog to Escherichia coli bnum: b1264; MultiFun: Metabolism 1.5.1.15. (520 aa)
trpGAnthranilate synthase component II: glutamine amidotransferase; Ortholog to Escherichia coli bnum: b1263; MultiFun: Metabolism 1.5.1.15. (198 aa)
trpDAnthranilate synthase component II: anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa)
trpCIndole-3-glycerolphosphate synthetase; Bifunctional; ortholog to Escherichia coli bnum: b1262; MultiFun: Metabolism 1.5.1.15; N-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpC family. (457 aa)
trpBTryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (276 aa)
pabBComponent of p-aminobenzoate synthase multienzyme complex; ortholog to Escherichia coli bnum: b1812; MultiFun: Metabolism 1.5.3.2. (462 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)
hisDL-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa)
hisCHistidinol-phosphate aminotransferase; Ortholog to Escherichia coli bnum: b2021; MultiFun: Metabolism 1.5.1.16; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa)
hisBHistidinol-phosphatase; Bifunctional; ortholog to Escherichia coli bnum: b2022; MultiFun: Metabolism 1.5.1.16; imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. (356 aa)
hisHGlutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide; Ortholog to Escherichia coli bnum: b2024; MultiFun: Metabolism 1.5.1.16. (246 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Bifunctional; ortholog to Escherichia coli bnum: b2026; MultiFun: Metabolism 1.5.1.16; phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (213 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa)
pabAAminodeoxychorismate synthase subunit II; Component of p-aminobenzoate synthase multienzyme complex; ortholog to Escherichia coli bnum: b3360; MultiFun: Metabolism 1.5.3.2. (193 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa)
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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