node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | folA | BPEN_190 | BPEN_128 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.640 |
birA | folB | BPEN_190 | BPEN_062 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | 0.589 |
birA | folC | BPEN_190 | BPEN_510 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.476 |
birA | folE | BPEN_190 | BPEN_487 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | GTP cyclohydrolase I; Ortholog to Escherichia coli bnum: b2153; MultiFun: Metabolism 1.5.3.2. | 0.519 |
birA | folK | BPEN_190 | BPEN_155 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2. | 0.549 |
birA | folP | BPEN_190 | BPEN_102 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.553 |
birA | ribA | BPEN_190 | BPEN_437 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. | 0.455 |
birA | ribD | BPEN_190 | BPEN_240 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.648 |
folA | birA | BPEN_128 | BPEN_190 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | 0.640 |
folA | folB | BPEN_128 | BPEN_062 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | 0.654 |
folA | folC | BPEN_128 | BPEN_510 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.960 |
folA | folE | BPEN_128 | BPEN_487 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GTP cyclohydrolase I; Ortholog to Escherichia coli bnum: b2153; MultiFun: Metabolism 1.5.3.2. | 0.681 |
folA | folK | BPEN_128 | BPEN_155 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2. | 0.650 |
folA | folP | BPEN_128 | BPEN_102 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.706 |
folA | ribD | BPEN_128 | BPEN_240 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.541 |
folB | birA | BPEN_062 | BPEN_190 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family). | 0.589 |
folB | folA | BPEN_062 | BPEN_128 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.654 |
folB | folC | BPEN_062 | BPEN_510 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.800 |
folB | folE | BPEN_062 | BPEN_487 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | GTP cyclohydrolase I; Ortholog to Escherichia coli bnum: b2153; MultiFun: Metabolism 1.5.3.2. | 0.949 |
folB | folK | BPEN_062 | BPEN_155 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate; Ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2. | 0.995 |