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| | lolB | Outer membrane lipoprotein precursor; Ortholog to Escherichia coli bnum: b1209; MultiFun: Cell structure 6.1. (205 aa) |
| | lpp | Murein lipoprotein; Ortholog to Escherichia coli bnum: b1677; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7. (78 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (337 aa) |
| | msbA | Lipid transport protein; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (584 aa) |
| | ftsK | Cell division protein; Ortholog to Escherichia coli bnum: b0890; MultiFun: Cell processes 5.1, 5.8; Cell structure 6.1; Transport 4.9.A.16; Belongs to the FtsK/SpoIIIE/SftA family. (793 aa) |
| | oprC | OprC; Outer membrane protein. (718 aa) |
| | emtA | Membrane-bound lytic murein transglycosylase E; Ortholog to Escherichia coli bnum: b1193; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7. (214 aa) |
| | lolE | Transport protein of outer membrane lipoproteins (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1118; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106. (411 aa) |
| | lolD | Transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind); Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (233 aa) |
| | lolC | Transport protein of outer membrane lipoproteins (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1116; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106. (401 aa) |
| | ycfM | Putative fibronectin-binding protein; Ortholog to Escherichia coli bnum: b1105. (178 aa) |
| | rne | Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (866 aa) |
| | lpxL | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (307 aa) |
| | pgsA | Phosphotidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (183 aa) |
| | yciC | Putative membrane protein, transport; Ortholog to Escherichia coli bnum: b1255; MultiFun: Cell structure 6.1. (245 aa) |
| | tonB | Energy transducer; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (242 aa) |
| | cls | Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (489 aa) |
| | sppA | Protease IV; Signal peptide peptidase; ortholog to Escherichia coli bnum: b1766; MultiFun: Metabolism 1.2.3. (625 aa) |
| | dsbB | Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (174 aa) |
| | minD | MinD; Cell division inhibitor; septum site determining protein; ortholog to Escherichia coli bnum: b1175; MultiFun: Cell processes 5.1; Cell structure 6.1. (270 aa) |
| | minE | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (87 aa) |
| | yoaE | Putative transmembrane protein; Ortholog to Escherichia coli bnum: b1816; MultiFun: Cell structure 6.1. (518 aa) |
| | manX | PTS family enzyme IIA/enzyme IIB, mannose-specific; Ortholog to Escherichia coli bnum: b1817; MultiFun: Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116. (327 aa) |
| | manY | PTS family enzyme IIC, mannose-specific; Ortholog to Escherichia coli bnum: b1818; MultiFun: Cell structure 6.1; Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116. (269 aa) |
| | manZ | PTS family enzyme IID, mannose-specific; Ortholog to Escherichia coli bnum: b1819; MultiFun: Cell structure 6.1; Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116. (288 aa) |
| | htpX | Heat shock protein; Integral membrane protein; ortholog to Escherichia coli bnum: b1829; MultiFun: Cell processes 5.5.2; Cell structure 6.1. (311 aa) |
| | mviN | Putative virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (515 aa) |
| | yceL | Putative membrane transporter (MFS family); Ortholog to Escherichia coli bnum: b1065; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.1, 4.S.126. (407 aa) |
| | omp | Outer membrane protein; Ortholog to Escherichia coli bnum: b2215; MultiFun: Cell structure 6.1; Transport 4.1.B.1, 4.S.92. (373 aa) |
| | nuoN | NADH dehydrogenase I chain N, membrane subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (497 aa) |
| | nuoM | NADH dehydrogenase I chain M, membrane subunit; Ortholog to Escherichia coli bnum: b2277; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130. (513 aa) |
| | nuoL | NADH dehydrogenase I chain L, membrane subunit; Ortholog to Escherichia coli bnum: b2278; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130. (628 aa) |
| | nuoK | NADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa) |
| | nuoJ | NADH dehydrogenase I chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (183 aa) |
| | nuoI | NADH dehydrogenase I chain I, 2Fe-2S ferredoxin-related; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (181 aa) |
| | nuoH | NADH dehydrogenase I chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (323 aa) |
| | nuoG | NADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (919 aa) |
| | nuoF | NADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (443 aa) |
| | nuoE | NADH dehydrogenase I chain E; Ortholog to Escherichia coli bnum: b2285; MultiFun: Metabolism 1.3.6; Metabolism 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130. (173 aa) |
| | nuoCD | NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. (596 aa) |
| | nuoB | NADH dehydrogenase I chain B, binds FeS cluster N2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (236 aa) |
| | nuoA | NADH dehydrogenase I chain A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (146 aa) |
| | mntH | Manganese/divalent cation transport protein (NRAMP family); H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. (411 aa) |
| | nupC | Nucleoside transport protein (NUP family); Ortholog to Escherichia coli bnum: b2393; MultiFun: Cell structure 6.1; Metabolism 1.7.33; Transport 4.2.A.41, 4.S.146. (396 aa) |
| | cysA | Sulfate permease A protein, chromate resistance (ABC superfamily, atp_bind); Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (355 aa) |
| | cysW | Thiosulfate permease W protein (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b2423; MultiFun: Cell structure 6.1; Metabolism 1.8.2; Transport 4.3.A.1.m, 4.S.178. (286 aa) |
| | cysU | Thiosulfate transport protein (ABC superfamily, membrane); Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa) |
| | BPEN_535 | Conserved hypothetical protein (NT02BF0496). (103 aa) |
| | mqo | Probable malate:quinone oxidoreductase; Ortholog to Escherichia coli bnum: b2210; MultiFun: Metabolism 1.3.4; malate dehydrogenase. (515 aa) |
| | lepB | Signal peptidase I; Ortholog to Escherichia coli bnum: b2568; MultiFun: Cell structure 6.1; Information transfer 2.3.5; Transport 4.S.160; Belongs to the peptidase S26 family. (331 aa) |
| | lepA | GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (600 aa) |
| | smpA | Small membrane protein A; Ortholog to Escherichia coli bnum: b2617; MultiFun: Cell structure 6.1. (112 aa) |
| | emrE | Auxillary multidrug transport protein (SMR family); Ortholog to Escherichia coli bnum: b0543; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.7, 4.S.126. (109 aa) |
| | pssA | Phosphatidylserine synthase; Ortholog to Escherichia coli bnum: b2585; MultiFun: Cell structure 6.1; Metabolism 1.6.1; CDP-diacylglycerol-serine O-phosphatidyltransferase. (458 aa) |
| | secE | Preprotein translocase, membrane component; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (115 aa) |
| | tuf | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa) |
| | yhgN | Putative integral membrane protein; Ortholog to Escherichia coli bnum: b3434; MultiFun: Cell structure 6.1. (197 aa) |
| | corA | Mg2+/Ni2+/Co2+ transport protein (Mg transport system I) (MIT family); Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake (By similarity). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity). Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (314 aa) |
| | rfaC | ADP-heptose; Ortholog to Escherichia coli bnum: b3621; MultiFun: Cell structure 6.3; Metabolism 1.6.3.2. (323 aa) |
| | kdtA | Kdo transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (427 aa) |
| | ubiB | 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (546 aa) |
| | rpoH | RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (282 aa) |
| | ftsY | Cell division protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (308 aa) |
| | atpB | ATP synthase, F0 sector, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (269 aa) |
| | atpE | ATP synthase, F0 sector, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpF | ATP synthase, F0 sector, subunit b; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (160 aa) |
| | atpH | ATP synthase, F1 sector, delta-subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (181 aa) |
| | atpA | ATP synthase, F1 sector, alpha-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpG | ATP synthase, F1 sector, gamma-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa) |
| | atpD | ATP synthase, F1 sector, beta-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (462 aa) |
| | atpC | ATP synthase, F1 sector, epsilon-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (144 aa) |
| | yidCD | Putative protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily. (638 aa) |
| | BPEN_018 | Probable transmembrane protein. (335 aa) |
| | pitA | Low-affinity phosphate transport protein (PiT family); Ortholog to Escherichia coli bnum: b3493; MultiFun: Cell structure 6.1; Metabolism 1.8.1; Transport 4.2.A.20, 4.S.155. (540 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (290 aa) |
| | yjcE | Putative sodium:hydrogen antiporter (CPA1 family); Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (547 aa) |
| | gltP | Glutamate:aspartate symporter (DAACS family); Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (429 aa) |
| | yjgP | Putative transmembrane protein, transport; Ortholog to Escherichia coli bnum: b4261; MultiFun: Cell structure 6.1; Transport 4. (373 aa) |
| | yjgQ | Putative transmembrane protein, transport; Ortholog to Escherichia coli bnum: b4262; MultiFun: Cell structure 6.1. (357 aa) |
| | znuC | High-affinity Zn transport protein (ABC superfamily, atp_bind); Ortholog to Escherichia coli bnum: b1858; MultiFun: Metabolism 1.5.3.12; Transport 4.3.A.1.a, 4.S.191. (215 aa) |
| | znuB | High-affinity Zn transport protein (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1859; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.191. (286 aa) |
| | yhbG | Putative transport protein (ABC superfamily, atp_bind); Ortholog to Escherichia coli bnum: b3201; MultiFun: Transport 4.3.A.1.a. (241 aa) |
| | yrbK | Possible exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (205 aa) |
| | yhcB | Conserved hypothetical protein; Ortholog to Escherichia coli bnum: b3233. (132 aa) |
| | yraP | Putative periplasmic protein; Ortholog to Escherichia coli bnum: b3150; MultiFun: Transport 4.9.B. (196 aa) |
| | yqjA | Putative membrane protein; Ortholog to Escherichia coli bnum: b3095; MultiFun: Cell structure 6.1. (188 aa) |
| | ygiH | Putative membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (195 aa) |
| | bacA | Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (294 aa) |
| | plsC | 1-acyl-glycerol-3-phosphate acyltransferase; Ortholog to Escherichia coli bnum: b3018; MultiFun: Cell structure 6.1; Metabolism 1.5.4; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (245 aa) |
| | yjeP | Putative membrane protein; Ortholog to Escherichia coli bnum: b4159; MultiFun: Transport 4.9.B. (1130 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (295 aa) |
| | hflK | HflK; HflC and HflK could encode or regulate a protease. (431 aa) |
| | hflC | HflC; HflC and HflK could regulate a protease. (342 aa) |
| | ytfM | Putative outer membrane protein; Ortholog to E. coli bnum: b4220; in-frame premature UAG termination codon is located within the ytfM sequence, and a -1 frameshift would be required for synthesis of ytfM; RNA polymerase or ribosomal slippage; possible young pseudogene; MultiFun: Cell structure 6.1. (587 aa) |
| | hflB | HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (642 aa) |
| | secG | Preprotein translocase, membrane component; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (93 aa) |
| | lspA | Prolipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (165 aa) |
| | imp | Organic solvent tolerance protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (782 aa) |
| | ftsL | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (104 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (362 aa) |
| | ftsW | Cell division protein; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (398 aa) |
| | ftsQ | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (264 aa) |
| | ftsA | Cell division protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (418 aa) |
| | secA | Preprotein translocase, ATPase secretion component; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (911 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2. (164 aa) |
| | nlpD | Lipoprotein NlpD precursor; Ortholog to Escherichia coli bnum: b2742; MultiFun: Cell structure 6.1. (317 aa) |
| | yfiO | Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (247 aa) |
| | secY | Preprotein translocase, membrane component; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (445 aa) |
| | yajC | Preprotein translocase, auxillary membrane component; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (115 aa) |
| | secD | Preprotein translocase, auxillary membrane component; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (619 aa) |
| | secF | Preprotein translocase, auxillary membrane component; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (305 aa) |
| | pgpA | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (163 aa) |
| | yajR | Putative transport protein (MFS family); Ortholog to Escherichia coli bnum: b0427; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.1,4.S.49. (386 aa) |
| | cyoE | Protohaeme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (294 aa) |
| | cyoD | Cytochrome o ubiquinol oxidase, subunit IV; Ortholog to Escherichia coli bnum: b0429; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2. (100 aa) |
| | cyoC | Cytochrome o ubiquinol oxidase, subunit III; Ortholog to Escherichia coli bnum: b0430; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82. (195 aa) |
| | cyoB | Cytochrome o ubiquinol oxidase, subunit I; Ortholog to Escherichia coli bnum: b0431; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82; Belongs to the heme-copper respiratory oxidase family. (653 aa) |
| | cyoA | Cytochrome o ubiquinol oxidase, subunit II; Ortholog to Escherichia coli bnum: b0432; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82. (294 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (281 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. (286 aa) |
| | ecfE | Putative membrane protein; Ortholog to Escherichia coli bnum: b0176; MultiFun: Cell processes 5.5; Cell structure 6.1; Regulation 3.1.3.4. (457 aa) |
| | yaeT | Outer membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (807 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (387 aa) |
| | mreB | Rod shape-determining protein; Ortholog to Escherichia coli bnum: b3251; MultiFun: Cell processes 5.1; Cell processes 5.6.4. (347 aa) |
| | mreC | Rod shape-determining protein; Involved in formation and maintenance of cell shape. (271 aa) |
| | mreD | Rod shape-determining protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (159 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (250 aa) |
| | ytfF | Putative cationic amino acid transport protein; Ortholog to Escherichia coli bnum: b4210; MultiFun: Transport 4, 4.S.12. (313 aa) |
| | mrdB | Rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | mrdA | Cell elongation-specific transpeptidase of penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (616 aa) |
| | rlpB | Rare lipoprotein B precursor; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (187 aa) |
| | lnt | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (510 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b-556 subunit; Ortholog to Escherichia coli bnum: b0721; MultiFun: Cell structure 6.1; Metabolism 1.3.4, 1.3.6, 1.4.1, 1.4.3, 1.6.15.1. (135 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhA | Succinate dehydrogenase catalytic and flavoprotein subunit; Ortholog to Escherichia coli bnum: b0723; MultiFun: Metabolism 1.3.4, 1.3.6, 1.4.1; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (594 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein; Ortholog to Escherichia coli bnum: b0724; MultiFun: Metabolism 1.3.4, 1.3.6, 1.4.1. (248 aa) |
| | tolQ | TolQ; Inner membrane protein required for outer membrane integrity, uptake of group A colicins and phage DNA; ortholog to Escherichia coli bnum: b0737; MultiFun: Cell structure 6.1. (249 aa) |
| | tolR | TolR; Role in outer membrane integrity, uptake of group A colicins (TonB-independent), and phage DNA; ortholog to Escherichia coli bnum: b0738; MultiFun: Cell structure 6.1. (141 aa) |
| | pal | Pal; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (175 aa) |
| | ybhL | Putative transport protein; Ortholog to Escherichia coli bnum: b0786; MultiFun: Cell structure 6.1; Transport 4; Belongs to the BI1 family. (236 aa) |
