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sppA sppA lolC lolC ftsK ftsK msbA msbA tolR tolR tolQ tolQ lnt lnt lgt lgt cyoC cyoC cyoD cyoD yajR yajR pgpA pgpA yajC yajC folK folK ftsQ ftsQ ftsW ftsW ftsL ftsL lspA lspA hflC hflC hflK hflK bacA bacA yrbK yrbK yhbG yhbG znuB znuB znuC znuC yjgQ yjgQ yjgP yjgP secE secE emrE emrE cysW cysW cysA cysA nupC nupC nuoA nuoA nuoB nuoB nuoE nuoE nuoG nuoG nuoH nuoH nuoI nuoI nuoJ nuoJ nuoK nuoK nuoL nuoL nuoN nuoN yceL yceL mviN mviN htpX htpX manZ manZ manY manY manX manX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sppAProtease IV; Signal peptide peptidase; ortholog to Escherichia coli bnum: b1766; MultiFun: Metabolism 1.2.3. (625 aa)
lolCTransport protein of outer membrane lipoproteins (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1116; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106. (401 aa)
ftsKCell division protein; Ortholog to Escherichia coli bnum: b0890; MultiFun: Cell processes 5.1, 5.8; Cell structure 6.1; Transport 4.9.A.16; Belongs to the FtsK/SpoIIIE/SftA family. (793 aa)
msbALipid transport protein; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (584 aa)
tolRTolR; Role in outer membrane integrity, uptake of group A colicins (TonB-independent), and phage DNA; ortholog to Escherichia coli bnum: b0738; MultiFun: Cell structure 6.1. (141 aa)
tolQTolQ; Inner membrane protein required for outer membrane integrity, uptake of group A colicins and phage DNA; ortholog to Escherichia coli bnum: b0737; MultiFun: Cell structure 6.1. (249 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (510 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (281 aa)
cyoCCytochrome o ubiquinol oxidase, subunit III; Ortholog to Escherichia coli bnum: b0430; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82. (195 aa)
cyoDCytochrome o ubiquinol oxidase, subunit IV; Ortholog to Escherichia coli bnum: b0429; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2. (100 aa)
yajRPutative transport protein (MFS family); Ortholog to Escherichia coli bnum: b0427; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.1,4.S.49. (386 aa)
pgpAPhosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (163 aa)
yajCPreprotein translocase, auxillary membrane component; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (115 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2. (164 aa)
ftsQCell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (264 aa)
ftsWCell division protein; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (398 aa)
ftsLCell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (104 aa)
lspAProlipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (165 aa)
hflCHflC; HflC and HflK could regulate a protease. (342 aa)
hflKHflK; HflC and HflK could encode or regulate a protease. (431 aa)
bacABacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (294 aa)
yrbKPossible exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (205 aa)
yhbGPutative transport protein (ABC superfamily, atp_bind); Ortholog to Escherichia coli bnum: b3201; MultiFun: Transport 4.3.A.1.a. (241 aa)
znuBHigh-affinity Zn transport protein (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1859; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.191. (286 aa)
znuCHigh-affinity Zn transport protein (ABC superfamily, atp_bind); Ortholog to Escherichia coli bnum: b1858; MultiFun: Metabolism 1.5.3.12; Transport 4.3.A.1.a, 4.S.191. (215 aa)
yjgQPutative transmembrane protein, transport; Ortholog to Escherichia coli bnum: b4262; MultiFun: Cell structure 6.1. (357 aa)
yjgPPutative transmembrane protein, transport; Ortholog to Escherichia coli bnum: b4261; MultiFun: Cell structure 6.1; Transport 4. (373 aa)
secEPreprotein translocase, membrane component; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (115 aa)
emrEAuxillary multidrug transport protein (SMR family); Ortholog to Escherichia coli bnum: b0543; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.7, 4.S.126. (109 aa)
cysWThiosulfate permease W protein (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b2423; MultiFun: Cell structure 6.1; Metabolism 1.8.2; Transport 4.3.A.1.m, 4.S.178. (286 aa)
cysASulfate permease A protein, chromate resistance (ABC superfamily, atp_bind); Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (355 aa)
nupCNucleoside transport protein (NUP family); Ortholog to Escherichia coli bnum: b2393; MultiFun: Cell structure 6.1; Metabolism 1.7.33; Transport 4.2.A.41, 4.S.146. (396 aa)
nuoANADH dehydrogenase I chain A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (146 aa)
nuoBNADH dehydrogenase I chain B, binds FeS cluster N2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (236 aa)
nuoENADH dehydrogenase I chain E; Ortholog to Escherichia coli bnum: b2285; MultiFun: Metabolism 1.3.6; Metabolism 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130. (173 aa)
nuoGNADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (919 aa)
nuoHNADH dehydrogenase I chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (323 aa)
nuoINADH dehydrogenase I chain I, 2Fe-2S ferredoxin-related; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (181 aa)
nuoJNADH dehydrogenase I chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (183 aa)
nuoKNADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoLNADH dehydrogenase I chain L, membrane subunit; Ortholog to Escherichia coli bnum: b2278; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130. (628 aa)
nuoNNADH dehydrogenase I chain N, membrane subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (497 aa)
yceLPutative membrane transporter (MFS family); Ortholog to Escherichia coli bnum: b1065; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.1, 4.S.126. (407 aa)
mviNPutative virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (515 aa)
htpXHeat shock protein; Integral membrane protein; ortholog to Escherichia coli bnum: b1829; MultiFun: Cell processes 5.5.2; Cell structure 6.1. (311 aa)
manZPTS family enzyme IID, mannose-specific; Ortholog to Escherichia coli bnum: b1819; MultiFun: Cell structure 6.1; Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116. (288 aa)
manYPTS family enzyme IIC, mannose-specific; Ortholog to Escherichia coli bnum: b1818; MultiFun: Cell structure 6.1; Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116. (269 aa)
manXPTS family enzyme IIA/enzyme IIB, mannose-specific; Ortholog to Escherichia coli bnum: b1817; MultiFun: Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116. (327 aa)
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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