(12 nodes) Mixed, incl. Long hematopoietin receptor, single chain, conserved site, and Somatotropin/prolactin network (Vombatus ursinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GHR	Fibronectin type-III domain-containing protein. (646 aa)
	PRL	Uncharacterized protein. (228 aa)
	NAALADL1	N-acetylated alpha-linked acidic dipeptidase like 1. (740 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	CPQ	Peptidase_M28 domain-containing protein. (471 aa)
	MFSD8	MFS domain-containing protein. (530 aa)
	LOC114050862	Uncharacterized protein. (215 aa)
	NAALADL2	Uncharacterized protein. (778 aa)
	LEPR	Uncharacterized protein. (1162 aa)
	PRLR	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa)
	MPL	MPL proto-oncogene, thrombopoietin receptor. (651 aa)
	THPO	Uncharacterized protein. (365 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPQ	GHR	ENSVURP00010008317	ENSVURP00010001270	Peptidase_M28 domain-containing protein.	Fibronectin type-III domain-containing protein.	0.659
CPQ	LEP	ENSVURP00010008317	ENSVURP00010004545	Peptidase_M28 domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.694
CPQ	LEPR	ENSVURP00010008317	ENSVURP00010018906	Peptidase_M28 domain-containing protein.	Uncharacterized protein.	0.663
CPQ	LOC114050862	ENSVURP00010008317	ENSVURP00010013350	Peptidase_M28 domain-containing protein.	Uncharacterized protein.	0.668
CPQ	MFSD8	ENSVURP00010008317	ENSVURP00010010874	Peptidase_M28 domain-containing protein.	MFS domain-containing protein.	0.608
CPQ	MPL	ENSVURP00010008317	ENSVURP00010025480	Peptidase_M28 domain-containing protein.	MPL proto-oncogene, thrombopoietin receptor.	0.691
CPQ	PRL	ENSVURP00010008317	ENSVURP00010001694	Peptidase_M28 domain-containing protein.	Uncharacterized protein.	0.676
CPQ	PRLR	ENSVURP00010008317	ENSVURP00010019819	Peptidase_M28 domain-containing protein.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.589
CPQ	THPO	ENSVURP00010008317	ENSVURP00010030363	Peptidase_M28 domain-containing protein.	Uncharacterized protein.	0.608
GHR	CPQ	ENSVURP00010001270	ENSVURP00010008317	Fibronectin type-III domain-containing protein.	Peptidase_M28 domain-containing protein.	0.659
GHR	LEP	ENSVURP00010001270	ENSVURP00010004545	Fibronectin type-III domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.879
GHR	LEPR	ENSVURP00010001270	ENSVURP00010018906	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.518
GHR	LOC114050862	ENSVURP00010001270	ENSVURP00010013350	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.993
GHR	NAALADL1	ENSVURP00010001270	ENSVURP00010003575	Fibronectin type-III domain-containing protein.	N-acetylated alpha-linked acidic dipeptidase like 1.	0.659
GHR	NAALADL2	ENSVURP00010001270	ENSVURP00010016545	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.659
GHR	PRL	ENSVURP00010001270	ENSVURP00010001694	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.918
GHR	PRLR	ENSVURP00010001270	ENSVURP00010019819	Fibronectin type-III domain-containing protein.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.866
LEP	CPQ	ENSVURP00010004545	ENSVURP00010008317	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Peptidase_M28 domain-containing protein.	0.694
LEP	GHR	ENSVURP00010004545	ENSVURP00010001270	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Fibronectin type-III domain-containing protein.	0.879
LEP	LEPR	ENSVURP00010004545	ENSVURP00010018906	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Uncharacterized protein.	0.989