(10 nodes) PDGF/VEGF domain, and VEGF-activated platelet-derived growth factor receptor signaling pathway network (Vombatus ursinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
	VEGFC	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (418 aa)
	PDGFRB	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
	PDGFC	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	LOC114051918	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (168 aa)
	FLT4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1377 aa)
	VEGFD	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (354 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FLT4	LOC114051918	ENSVURP00010025768	ENSVURP00010022751	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.880
FLT4	PDGFB	ENSVURP00010025768	ENSVURP00010003779	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.962
FLT4	PDGFC	ENSVURP00010025768	ENSVURP00010016307	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	0.941
FLT4	PDGFD	ENSVURP00010025768	ENSVURP00010018034	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.884
FLT4	PDGFRA	ENSVURP00010025768	ENSVURP00010013730	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.777
FLT4	PDGFRB	ENSVURP00010025768	ENSVURP00010010564	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.888
FLT4	PGF	ENSVURP00010025768	ENSVURP00010023708	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Placental growth factor; Belongs to the PDGF/VEGF growth factor family.	0.941
FLT4	VEGFC	ENSVURP00010025768	ENSVURP00010009382	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.995
FLT4	VEGFD	ENSVURP00010025768	ENSVURP00010029539	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.971
LOC114051918	FLT4	ENSVURP00010022751	ENSVURP00010025768	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.880
LOC114051918	PDGFB	ENSVURP00010022751	ENSVURP00010003779	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.921
LOC114051918	PDGFC	ENSVURP00010022751	ENSVURP00010016307	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	0.890
LOC114051918	PDGFD	ENSVURP00010022751	ENSVURP00010018034	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.877
LOC114051918	PDGFRA	ENSVURP00010022751	ENSVURP00010013730	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.980
LOC114051918	PDGFRB	ENSVURP00010022751	ENSVURP00010010564	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.928
LOC114051918	PGF	ENSVURP00010022751	ENSVURP00010023708	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Placental growth factor; Belongs to the PDGF/VEGF growth factor family.	0.803
LOC114051918	VEGFC	ENSVURP00010022751	ENSVURP00010009382	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.848
LOC114051918	VEGFD	ENSVURP00010022751	ENSVURP00010029539	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.843
PDGFB	FLT4	ENSVURP00010003779	ENSVURP00010025768	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.962
PDGFB	LOC114051918	ENSVURP00010003779	ENSVURP00010022751	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.921