(8 nodes) 1-phosphatidylinositol-3-kinase activity network (Vombatus ursinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	PIK3C2B	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1635 aa)
	PIK3CG	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1103 aa)
	PIK3CD	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
	PIK3C2A	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1688 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	PIK3C3	ENSVURP00010018477	ENSVURP00010028867	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.445
PIK3C2A	PIK3C2B	ENSVURP00010007756	ENSVURP00010017187	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
PIK3C2A	PIK3C3	ENSVURP00010007756	ENSVURP00010028867	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.751
PIK3C2A	PIK3CA	ENSVURP00010007756	ENSVURP00010016429	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.816
PIK3C2A	PIK3CB	ENSVURP00010007756	ENSVURP00010011407	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.825
PIK3C2A	PIK3CD	ENSVURP00010007756	ENSVURP00010031571	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.737
PIK3C2A	PIK3CG	ENSVURP00010007756	ENSVURP00010013835	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.799
PIK3C2B	PIK3C2A	ENSVURP00010017187	ENSVURP00010007756	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
PIK3C2B	PIK3C3	ENSVURP00010017187	ENSVURP00010028867	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.751
PIK3C2B	PIK3CA	ENSVURP00010017187	ENSVURP00010016429	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.830
PIK3C2B	PIK3CB	ENSVURP00010017187	ENSVURP00010011407	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.826
PIK3C2B	PIK3CD	ENSVURP00010017187	ENSVURP00010031571	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.714
PIK3C2B	PIK3CG	ENSVURP00010017187	ENSVURP00010013835	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.767
PIK3C3	ATM	ENSVURP00010028867	ENSVURP00010018477	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.445
PIK3C3	PIK3C2A	ENSVURP00010028867	ENSVURP00010007756	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.751
PIK3C3	PIK3C2B	ENSVURP00010028867	ENSVURP00010017187	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.751
PIK3C3	PIK3CA	ENSVURP00010028867	ENSVURP00010016429	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.861
PIK3C3	PIK3CB	ENSVURP00010028867	ENSVURP00010011407	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.855
PIK3C3	PIK3CD	ENSVURP00010028867	ENSVURP00010031571	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.855
PIK3C3	PIK3CG	ENSVURP00010028867	ENSVURP00010013835	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.854