(46 nodes) Bone mineralization network (Vombatus ursinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASPN	LRRNT domain-containing protein. (376 aa)
	ERCC2	Helicase ATP-binding domain-containing protein. (760 aa)
	LOC114050620	PX domain-containing protein. (202 aa)
	PKDCC	Protein kinase domain-containing protein. (490 aa)
	LGR4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (950 aa)
	FBXL15	F-box domain-containing protein. (351 aa)
	LTBP3	Uncharacterized protein. (1287 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (476 aa)
	ATF4	BZIP domain-containing protein. (349 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (449 aa)
	TMEM38B	Uncharacterized protein. (295 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
	CER1	CTCK domain-containing protein. (257 aa)
	IFITM5	Uncharacterized protein. (133 aa)
	PTHLH	Uncharacterized protein. (185 aa)
	SBDS	Uncharacterized protein. (250 aa)
	SLC24A3	Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (589 aa)
	KLF10	Uncharacterized protein. (486 aa)
	LOC114044833	Tyrosine-protein kinase. (531 aa)
	PHOSPHO1	Uncharacterized protein. (268 aa)
	EIF2AK3	Protein kinase domain-containing protein. (1005 aa)
	ENSVURP00010013594	Uncharacterized protein. (326 aa)
	ENSVURP00010014758	Uncharacterized protein. (219 aa)
	PHEX	Uncharacterized protein. (751 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	AXIN2	Uncharacterized protein. (837 aa)
	MMP13	ZnMc domain-containing protein. (480 aa)
	PTN	Uncharacterized protein. (168 aa)
	IFT80	WD_REPEATS_REGION domain-containing protein. (870 aa)
	SBNO2	Uncharacterized protein. (1397 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (814 aa)
	ENSVURP00010024717	Tyrosine-protein kinase. (479 aa)
	LOC114050620-2	PX domain-containing protein. (208 aa)
	PHOSPHO2	Phosphatase, orphan 2. (240 aa)
	ANKH	Uncharacterized protein. (492 aa)
	FGFR3	Fibroblast growth factor receptor. (851 aa)
	IBSP	Uncharacterized protein. (309 aa)
	CLEC3B	C-type lectin domain-containing protein. (202 aa)
	ENSVURP00010028913	SBDS domain-containing protein. (98 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (518 aa)
	ENSVURP00010030515	Uncharacterized protein. (748 aa)
	LOC114032638	Uncharacterized protein. (795 aa)
	ALPL	Alkaline phosphatase. (524 aa)
	IGF1	Insulin like growth factor 1. (229 aa)
	COL1A2	Fibrillar collagen NC1 domain-containing protein. (1336 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPL	IBSP	ENSVURP00010031034	ENSVURP00010027817	Alkaline phosphatase.	Uncharacterized protein.	0.483
ALPL	IFITM5	ENSVURP00010031034	ENSVURP00010006124	Alkaline phosphatase.	Uncharacterized protein.	0.483
ALPL	PHOSPHO1	ENSVURP00010031034	ENSVURP00010010090	Alkaline phosphatase.	Uncharacterized protein.	0.432
ASPN	CLEC3B	ENSVURP00010023599	ENSVURP00010028479	LRRNT domain-containing protein.	C-type lectin domain-containing protein.	0.430
ASPN	COL1A2	ENSVURP00010023599	ENSVURP00010032448	LRRNT domain-containing protein.	Fibrillar collagen NC1 domain-containing protein.	0.537
ASPN	ENSVURP00010030515	ENSVURP00010023599	ENSVURP00010030515	LRRNT domain-containing protein.	Uncharacterized protein.	0.423
ASPN	GPC3	ENSVURP00010023599	ENSVURP00010004279	LRRNT domain-containing protein.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.590
ASPN	IGF1	ENSVURP00010023599	ENSVURP00010031328	LRRNT domain-containing protein.	Insulin like growth factor 1.	0.523
ASPN	LOC114032638	ENSVURP00010023599	ENSVURP00010030607	LRRNT domain-containing protein.	Uncharacterized protein.	0.423
ATF4	EIF2AK3	ENSVURP00010003662	ENSVURP00010010286	BZIP domain-containing protein.	Protein kinase domain-containing protein.	0.948
AXIN2	WNT11	ENSVURP00010016537	ENSVURP00010022094	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.664
CER1	WNT11	ENSVURP00010005889	ENSVURP00010022094	CTCK domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.910
CLEC3B	ASPN	ENSVURP00010028479	ENSVURP00010023599	C-type lectin domain-containing protein.	LRRNT domain-containing protein.	0.430
COL1A2	ASPN	ENSVURP00010032448	ENSVURP00010023599	Fibrillar collagen NC1 domain-containing protein.	LRRNT domain-containing protein.	0.537
COL1A2	FGFR3	ENSVURP00010032448	ENSVURP00010027799	Fibrillar collagen NC1 domain-containing protein.	Fibroblast growth factor receptor.	0.567
COL1A2	LTBP3	ENSVURP00010032448	ENSVURP00010002210	Fibrillar collagen NC1 domain-containing protein.	Uncharacterized protein.	0.406
COL1A2	MMP13	ENSVURP00010032448	ENSVURP00010017405	Fibrillar collagen NC1 domain-containing protein.	ZnMc domain-containing protein.	0.464
EIF2AK3	ATF4	ENSVURP00010010286	ENSVURP00010003662	Protein kinase domain-containing protein.	BZIP domain-containing protein.	0.948
EIF2AK3	GPC3	ENSVURP00010010286	ENSVURP00010004279	Protein kinase domain-containing protein.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.566
ENSVURP00010013594	KLF10	ENSVURP00010013594	ENSVURP00010009320	Uncharacterized protein.	Uncharacterized protein.	0.426