28 items (Vombatus ursinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (540 aa)
	FBXO4	F-box domain-containing protein. (387 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	POT1	Telo_bind domain-containing protein. (782 aa)
	CCT2	Uncharacterized protein. (535 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	PARN	R3H domain-containing protein. (638 aa)
	ENSVURP00010012602	Uncharacterized protein. (133 aa)
	ATR	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2656 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1366 aa)
	NEK2	Protein kinase domain-containing protein. (445 aa)
	CCT4	T-complex protein 1 subunit delta. (539 aa)
	ENSVURP00010018356	Uncharacterized protein. (658 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (686 aa)
	ENSVURP00010022275	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (77 aa)
	LOC114031465	Protein kinase domain-containing protein. (1503 aa)
	DKC1	PUA domain-containing protein. (601 aa)
	LOC114031465-2	Protein kinase domain-containing protein. (1503 aa)
	CCT5	Uncharacterized protein. (541 aa)
	ACD	Uncharacterized protein. (492 aa)
	CTNNB1	Catenin beta 1. (744 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
	ENSVURP00010028815	annotation not available (77 aa)
	MAPKAPK5	Protein kinase domain-containing protein. (461 aa)
	MAP2K7	Protein kinase domain-containing protein. (462 aa)
	MAPK15	Mitogen-activated protein kinase 15. (545 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSVURP00010028010	ENSVURP00010024938	Uncharacterized protein.	PUA domain-containing protein.	0.835
ACD	POT1	ENSVURP00010028010	ENSVURP00010003785	Uncharacterized protein.	Telo_bind domain-containing protein.	0.998
ACD	TNKS	ENSVURP00010028010	ENSVURP00010014910	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.403
ATM	ATR	ENSVURP00010018477	ENSVURP00010013097	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.999
ATM	TNKS	ENSVURP00010018477	ENSVURP00010014910	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase.	0.424
ATM	XRCC5	ENSVURP00010018477	ENSVURP00010003661	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.987
ATR	ATM	ENSVURP00010013097	ENSVURP00010018477	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.999
ATR	ENSVURP00010018356	ENSVURP00010013097	ENSVURP00010018356	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.515
ATR	XRCC5	ENSVURP00010013097	ENSVURP00010003661	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.650
CCT2	CCT3	ENSVURP00010007324	ENSVURP00010018911	Uncharacterized protein.	T-complex protein 1 subunit gamma.	0.999
CCT2	CCT4	ENSVURP00010007324	ENSVURP00010017792	Uncharacterized protein.	T-complex protein 1 subunit delta.	0.999
CCT2	CCT5	ENSVURP00010007324	ENSVURP00010027866	Uncharacterized protein.	Uncharacterized protein.	0.999
CCT2	CCT7	ENSVURP00010007324	ENSVURP00010000539	Uncharacterized protein.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT2	ENSVURP00010012602	ENSVURP00010007324	ENSVURP00010012602	Uncharacterized protein.	Uncharacterized protein.	0.999
CCT2	ENSVURP00010022275	ENSVURP00010007324	ENSVURP00010022275	Uncharacterized protein.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.998
CCT2	ENSVURP00010028815	ENSVURP00010007324	ENSVURP00010028815	Uncharacterized protein.	annotation not available	0.998
CCT3	CCT2	ENSVURP00010018911	ENSVURP00010007324	T-complex protein 1 subunit gamma.	Uncharacterized protein.	0.999
CCT3	CCT4	ENSVURP00010018911	ENSVURP00010017792	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.999
CCT3	CCT5	ENSVURP00010018911	ENSVURP00010027866	T-complex protein 1 subunit gamma.	Uncharacterized protein.	0.999
CCT3	CCT7	ENSVURP00010018911	ENSVURP00010000539	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999