30 items (Vombatus ursinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSVURP00010019729	Uncharacterized protein. (150 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	TLR9	TIR domain-containing protein. (1041 aa)
	CD40	Uncharacterized protein. (276 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (253 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
	CCL19	C-C motif chemokine. (101 aa)
	ENSVURP00010019738	Uncharacterized protein. (153 aa)
	NOD2	Uncharacterized protein. (1012 aa)
	ENSVURP00010018452	Uncharacterized protein. (634 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	MDK	Uncharacterized protein. (142 aa)
	IDO1	Uncharacterized protein. (399 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	SYK	Uncharacterized protein. (639 aa)
	TLR3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (905 aa)
	IRF8	IRF tryptophan pentad repeat domain-containing protein. (426 aa)
	TIRAP	TIR domain containing adaptor protein. (217 aa)
	IL23A	Interleukin 23 subunit alpha. (188 aa)
	ENSVURP00010031247	PDZ domain-containing protein. (134 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	AGER	Uncharacterized protein. (412 aa)
	CCR7	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1335 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ENSVURP00010002986	Uncharacterized protein. (149 aa)
	LTB	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
	MAPK11	Mitogen-activated protein kinase. (362 aa)
	RELA	RHD domain-containing protein. (538 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	RELA	ENSVURP00010006977	ENSVURP00010001935	Uncharacterized protein.	RHD domain-containing protein.	0.715
AGER	TLR9	ENSVURP00010006977	ENSVURP00010022267	Uncharacterized protein.	TIR domain-containing protein.	0.468
CCL19	CCR7	ENSVURP00010019864	ENSVURP00010006579	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.928
CCL19	IFNG	ENSVURP00010019864	ENSVURP00010031608	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.466
CCR7	CCL19	ENSVURP00010006579	ENSVURP00010019864	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.928
CCR7	CD40	ENSVURP00010006579	ENSVURP00010021891	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.571
CCR7	CD40LG	ENSVURP00010006579	ENSVURP00010021602	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.532
CCR7	IFNG	ENSVURP00010006579	ENSVURP00010031608	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.568
CCR7	LTB	ENSVURP00010006579	ENSVURP00010002485	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.631
CCR7	NOD2	ENSVURP00010006579	ENSVURP00010026239	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.401
CD40	CCR7	ENSVURP00010021891	ENSVURP00010006579	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.571
CD40	CD40LG	ENSVURP00010021891	ENSVURP00010021602	Uncharacterized protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.995
CD40	IFNG	ENSVURP00010021891	ENSVURP00010031608	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.563
CD40	IRF1	ENSVURP00010021891	ENSVURP00010007615	Uncharacterized protein.	Interferon regulatory factor.	0.433
CD40	LTB	ENSVURP00010021891	ENSVURP00010002485	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.911
CD40	RELA	ENSVURP00010021891	ENSVURP00010001935	Uncharacterized protein.	RHD domain-containing protein.	0.567
CD40	SYK	ENSVURP00010021891	ENSVURP00010008906	Uncharacterized protein.	Uncharacterized protein.	0.452
CD40	TLR3	ENSVURP00010021891	ENSVURP00010008415	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.529
CD40	TLR9	ENSVURP00010021891	ENSVURP00010022267	Uncharacterized protein.	TIR domain-containing protein.	0.504
CD40	TRAF6	ENSVURP00010021891	ENSVURP00010015322	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.994