(121 nodes) Regulation of fat cell differentiation network (Vombatus ursinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZFPM2	Uncharacterized protein. (1151 aa)
	ZBTB7C	Uncharacterized protein. (619 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (503 aa)
	SYAP1	Synapse associated protein 1. (286 aa)
	ASXL2	Uncharacterized protein. (1448 aa)
	RUNX1T1	Uncharacterized protein. (607 aa)
	ENSVURP00010001276	Uncharacterized protein. (186 aa)
	PTPRQ	Protein tyrosine phosphatase receptor type Q. (2307 aa)
	MEX3C	RING-type domain-containing protein. (669 aa)
	CCDC85B	Uncharacterized protein. (248 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (492 aa)
	LOC114043682	Uncharacterized protein. (875 aa)
	ENSVURP00010002272	CCDC144C domain-containing protein. (295 aa)
	STK4	Uncharacterized protein. (487 aa)
	ENSVURP00010002802	Protein kinase domain-containing protein. (362 aa)
	LOC114031844	Uncharacterized protein. (268 aa)
	ADIPOQ	C1q domain-containing protein. (249 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (670 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	ENSVURP00010004377	ZnMc domain-containing protein. (440 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ARNTL	Uncharacterized protein. (633 aa)
	RREB1	Uncharacterized protein. (1785 aa)
	CREB1	Uncharacterized protein. (327 aa)
	ENSVURP00010006631	annotation not available (268 aa)
	DLK2	Uncharacterized protein. (400 aa)
	NR1D1	Uncharacterized protein. (622 aa)
	ENSVURP00010007480	CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (607 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	TPH1	Uncharacterized protein. (444 aa)
	C1QL4	C1q domain-containing protein. (237 aa)
	STK3	Uncharacterized protein. (491 aa)
	KALRN	Kalirin RhoGEF kinase. (2312 aa)
	RARRES2	Uncharacterized protein. (172 aa)
	CREBL2	BZIP domain-containing protein. (120 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	FERMT2	PH domain-containing protein. (687 aa)
	TRPV4	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	LOC114049562	Uncharacterized protein. (838 aa)
	ENSVURP00010020662	annotation not available (838 aa)
	ENSVURP00010020672	annotation not available (875 aa)
	RORA	Uncharacterized protein. (523 aa)
	ENSVURP00010020783	CARM1 domain-containing protein. (159 aa)
	ENSVURP00010020795	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (228 aa)
	ADIRF	Uncharacterized protein. (80 aa)
	GATA2	Uncharacterized protein. (473 aa)
	ENSVURP00010022058	annotation not available (482 aa)
	ENSVURP00010022607	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	LOC114043223-2	Uncharacterized protein. (511 aa)
	WDFY2	Uncharacterized protein. (400 aa)
	JDP2	BZIP domain-containing protein. (180 aa)
	FRZB	Uncharacterized protein. (321 aa)
	ENSVURP00010023788	CCDC144C domain-containing protein. (266 aa)
	ZBTB16	Uncharacterized protein. (562 aa)
	PPARD	Uncharacterized protein. (442 aa)
	FFAR4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (356 aa)
	E2F1	E2F transcription factor 1. (431 aa)
	ENSVURP00010025333	annotation not available (375 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
	FNDC5	Fibronectin type III domain containing 5. (152 aa)
	ZADH2	Zinc binding alcohol dehydrogenase domain containing 2. (435 aa)
	MEDAG	Uncharacterized protein. (318 aa)
	LOC114030223	Uncharacterized protein. (1709 aa)
	ENSVURP00010026992	ZnMc domain-containing protein. (352 aa)
	ZFPM1	Uncharacterized protein. (1226 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3036 aa)
	ENSVURP00010028624	annotation not available (159 aa)
	ENSVURP00010028627	annotation not available (228 aa)
	ENSVURP00010028996	Uncharacterized protein. (517 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (170 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (386 aa)
	ZFP36	Uncharacterized protein. (374 aa)
	ZFP36L1	Uncharacterized protein. (338 aa)
	HTR2A	G_PROTEIN_RECEP_F1_2 domain-containing protein. (469 aa)
	TRIB2	Protein kinase domain-containing protein. (343 aa)
	ENSVURP00010031082	CCDC144C domain-containing protein. (293 aa)
	ENSVURP00010031085	ANK_REP_REGION domain-containing protein. (258 aa)
	ENSVURP00010031090	ANK_REP_REGION domain-containing protein. (1638 aa)
	WIF1	Uncharacterized protein. (379 aa)
	NOCT	Endo/exonuclease/phosphatase domain-containing protein. (452 aa)
	ENSVURP00010032261	Uncharacterized protein. (450 aa)
	SIRT6	Deacetylase sirtuin-type domain-containing protein. (345 aa)
	ZNF385A	Uncharacterized protein. (386 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (480 aa)
	TAF8	BTP domain-containing protein. (357 aa)
	FPR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	TLCD3B	TLC domain-containing protein. (282 aa)
	TGFB1I1	Uncharacterized protein; Belongs to the paxillin family. (458 aa)
	KLF5	Uncharacterized protein. (464 aa)
	LOC114050197	Uncharacterized protein. (482 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (577 aa)
	XBP1	X-box binding protein 1. (266 aa)
	HDAC6	UBP-type domain-containing protein. (1053 aa)
	DKKL1	Uncharacterized protein. (244 aa)
	TFE3	BHLH domain-containing protein. (561 aa)
	CCDC71L	Uncharacterized protein. (273 aa)
	WWTR1	WW domain containing transcription regulator 1. (401 aa)
	ENSVURP00010014468	annotation not available (326 aa)
	PTGS2	EGF-like domain-containing protein. (608 aa)
	SFRP2	Uncharacterized protein. (295 aa)
	NAPEPLD	Lactamase_B domain-containing protein. (396 aa)
	AXIN2	Uncharacterized protein. (837 aa)
	FNDC3B	Uncharacterized protein. (1211 aa)
	TRPM4	Uncharacterized protein. (1222 aa)
	LOC114023935	Uncharacterized protein. (379 aa)
	YAP1	Uncharacterized protein. (512 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (539 aa)
	METRNL	Uncharacterized protein. (307 aa)
	CCN4	Cellular communication network factor 4. (249 aa)
	SOX13	SRY-box 13. (603 aa)
	VSTM2A	Ig-like domain-containing protein. (240 aa)
	ASXL1	Uncharacterized protein. (1566 aa)
	LOC114043223	Uncharacterized protein. (533 aa)
	ENSVURP00010018508	annotation not available (362 aa)
	GATA3	Uncharacterized protein. (444 aa)
	SORT1	Sortilin. (833 aa)
	BBS12	Uncharacterized protein. (703 aa)
	SIRT1	Sirtuin 1. (550 aa)
	ALOX5	Uncharacterized protein. (674 aa)
	LOC114049705	Uncharacterized protein. (528 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	LEP	ENSVURP00010002868	ENSVURP00010004545	C1q domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.910
ADIPOQ	LPL	ENSVURP00010002868	ENSVURP00010010697	C1q domain-containing protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.455
ADIPOQ	PPARG	ENSVURP00010002868	ENSVURP00010017182	C1q domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.673
ADIPOQ	RARRES2	ENSVURP00010002868	ENSVURP00010009355	C1q domain-containing protein.	Uncharacterized protein.	0.432
ADIPOQ	SIRT1	ENSVURP00010002868	ENSVURP00010020308	C1q domain-containing protein.	Sirtuin 1.	0.552
ADIRF	PPARG	ENSVURP00010021367	ENSVURP00010017182	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.630
ALOX5	KALRN	ENSVURP00010020519	ENSVURP00010008762	Uncharacterized protein.	Kalirin RhoGEF kinase.	0.402
ALOX5	PTGS2	ENSVURP00010020519	ENSVURP00010015374	Uncharacterized protein.	EGF-like domain-containing protein.	0.914
ALOX5	TRIO	ENSVURP00010020519	ENSVURP00010027635	Uncharacterized protein.	Trio Rho guanine nucleotide exchange factor.	0.402
ARNTL	ENSVURP00010007480	ENSVURP00010004922	ENSVURP00010007480	Uncharacterized protein.	CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.595
ARNTL	ENSVURP00010014468	ENSVURP00010004922	ENSVURP00010014468	Uncharacterized protein.	annotation not available	0.518
ARNTL	ENSVURP00010020783	ENSVURP00010004922	ENSVURP00010020783	Uncharacterized protein.	CARM1 domain-containing protein.	0.595
ARNTL	ENSVURP00010020795	ENSVURP00010004922	ENSVURP00010020795	Uncharacterized protein.	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.595
ARNTL	ENSVURP00010028624	ENSVURP00010004922	ENSVURP00010028624	Uncharacterized protein.	annotation not available	0.595
ARNTL	ENSVURP00010028627	ENSVURP00010004922	ENSVURP00010028627	Uncharacterized protein.	annotation not available	0.595
ARNTL	JDP2	ENSVURP00010004922	ENSVURP00010023598	Uncharacterized protein.	BZIP domain-containing protein.	0.434
ARNTL	LOC114043223	ENSVURP00010004922	ENSVURP00010018367	Uncharacterized protein.	Uncharacterized protein.	0.663
ARNTL	LOC114043223-2	ENSVURP00010004922	ENSVURP00010022687	Uncharacterized protein.	Uncharacterized protein.	0.663
ARNTL	NOCT	ENSVURP00010004922	ENSVURP00010032194	Uncharacterized protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.547
ARNTL	NR1D1	ENSVURP00010004922	ENSVURP00010006870	Uncharacterized protein.	Uncharacterized protein.	0.702