(45 nodes) Positive regulation of fibroblast proliferation network (Vombatus ursinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTC1	Uncharacterized protein. (1204 aa)
	ENSVURP00010000537	Uncharacterized protein. (770 aa)
	ENSVURP00010001332	Uncharacterized protein. (602 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
	DDR2	Uncharacterized protein. (862 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
	FN1	Uncharacterized protein. (2476 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	LOC114046119	DNA ligase. (911 aa)
	ENSVURP00010008204	annotation not available (602 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	PLA2G1B	Phospholipase A(2). (133 aa)
	CD74	Thyroglobulin type-1 domain-containing protein. (275 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
	ENSVURP00010012149	Integrin beta; Belongs to the integrin beta chain family. (761 aa)
	EREG	Epiregulin. (165 aa)
	DHX9	Uncharacterized protein. (1258 aa)
	PML	Uncharacterized protein. (900 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
	LIF	Uncharacterized protein. (202 aa)
	SPHK1	DAGKc domain-containing protein. (394 aa)
	BRK1	BRICK1 subunit of SCAR/WAVE actin nucleating complex. (102 aa)
	LOC114030664	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (448 aa)
	PDGFC	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	ENSVURP00010016370	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (539 aa)
	LOC114040384	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
	FNDC3B	Uncharacterized protein. (1211 aa)
	ENSVURP00010017759	annotation not available (448 aa)
	ZMIZ1	SP-RING-type domain-containing protein. (1081 aa)
	WAPL	WAPL domain-containing protein. (1198 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	LOC114051918	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	E2F1	E2F transcription factor 1. (431 aa)
	CDKN1A	Uncharacterized protein. (164 aa)
	ENSVURP00010025478	annotation not available (211 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	FOSL2	BZIP domain-containing protein. (325 aa)
	NDUFS4	Uncharacterized protein. (171 aa)
	ENSVURP00010028471	Uncharacterized protein. (285 aa)
	ENSVURP00010029369	annotation not available (911 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (294 aa)
	BMI1	RING-type domain-containing protein. (327 aa)
	IGF1	Insulin like growth factor 1. (229 aa)
	SIRT6	Deacetylase sirtuin-type domain-containing protein. (345 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMI1	CDK6	ENSVURP00010030417	ENSVURP00010029535	RING-type domain-containing protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.456
BMI1	E2F1	ENSVURP00010030417	ENSVURP00010025221	RING-type domain-containing protein.	E2F transcription factor 1.	0.709
BMI1	ENSVURP00010000537	ENSVURP00010030417	ENSVURP00010000537	RING-type domain-containing protein.	Uncharacterized protein.	0.641
BMI1	ENSVURP00010017759	ENSVURP00010030417	ENSVURP00010017759	RING-type domain-containing protein.	annotation not available	0.735
BMI1	LOC114030664	ENSVURP00010030417	ENSVURP00010015233	RING-type domain-containing protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.687
BMI1	PDGFB	ENSVURP00010030417	ENSVURP00010003779	RING-type domain-containing protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.422
BRK1	ENSVURP00010012149	ENSVURP00010014981	ENSVURP00010012149	BRICK1 subunit of SCAR/WAVE actin nucleating complex.	Integrin beta; Belongs to the integrin beta chain family.	0.618
CD74	DHX9	ENSVURP00010009957	ENSVURP00010013064	Thyroglobulin type-1 domain-containing protein.	Uncharacterized protein.	0.574
CDK6	BMI1	ENSVURP00010029535	ENSVURP00010030417	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	RING-type domain-containing protein.	0.456
CDK6	CDKN1A	ENSVURP00010029535	ENSVURP00010025319	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.997
CDK6	E2F1	ENSVURP00010029535	ENSVURP00010025221	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	E2F transcription factor 1.	0.899
CDK6	ENSVURP00010000537	ENSVURP00010029535	ENSVURP00010000537	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.778
CDK6	ENSVURP00010016370	ENSVURP00010029535	ENSVURP00010016370	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.959
CDK6	ENSVURP00010017759	ENSVURP00010029535	ENSVURP00010017759	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	annotation not available	0.624
CDK6	ESR1	ENSVURP00010029535	ENSVURP00010001958	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.460
CDK6	JUN	ENSVURP00010029535	ENSVURP00010010125	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.772
CDK6	LOC114030664	ENSVURP00010029535	ENSVURP00010015233	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.471
CDK6	LOC114040384	ENSVURP00010029535	ENSVURP00010016424	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.959
CDK6	WAPL	ENSVURP00010029535	ENSVURP00010020807	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	WAPL domain-containing protein.	0.682
CDKN1A	CDK6	ENSVURP00010025319	ENSVURP00010029535	Uncharacterized protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.997