STRINGSTRING
SRCIN1 SRCIN1 LOC114049551 LOC114049551 NEURL1 NEURL1 ENSVURP00010000763 ENSVURP00010000763 EPO EPO IL34 IL34 ENSVURP00010001332 ENSVURP00010001332 ENSVURP00010001704 ENSVURP00010001704 ADRA1A ADRA1A RICTOR RICTOR LOC114050566 LOC114050566 SH2D1B SH2D1B GDNF GDNF DLG4 DLG4 ENSVURP00010003469 ENSVURP00010003469 PDGFB PDGFB NEDD9 NEDD9 TP53 TP53 IL11 IL11 ERBB4 ERBB4 BMP6 BMP6 PTPN11 PTPN11 FGF7 FGF7 CNTN1 CNTN1 ENSVURP00010005671 ENSVURP00010005671 NCF1 NCF1 PTPRC PTPRC HPX HPX VEGFA VEGFA RIPK2 RIPK2 CSF3 CSF3 HCLS1 HCLS1 ENSVURP00010007261 ENSVURP00010007261 NOX4 NOX4 IL5 IL5 PARP9 PARP9 EFNA5 EFNA5 ENSVURP00010008204 ENSVURP00010008204 LOC114053900 LOC114053900 ENSVURP00010008450 ENSVURP00010008450 JAK2 JAK2 SYK SYK PLPP3 PLPP3 CD74 CD74 LTK LTK TNK2 TNK2 PAK2 PAK2 CSF1R CSF1R ITGA5 ITGA5 GREM1 GREM1 ENSVURP00010012149 ENSVURP00010012149 PIBF1 PIBF1 ENSVURP00010012287 ENSVURP00010012287 LRRK1 LRRK1 HBEGF HBEGF PTPRJ PTPRJ EPGN EPGN EREG EREG AREG AREG MLST8 MLST8 IL15 IL15 ENSVURP00010013239 ENSVURP00010013239 LRP4 LRP4 ENSVURP00010013594 ENSVURP00010013594 UNC119 UNC119 KIT KIT LOC114031872 LOC114031872 VTN VTN LIF LIF OSM OSM RELN RELN GHRL GHRL SEMA4D SEMA4D IGF2 IGF2 TGFA TGFA PRNP PRNP FBXW7 FBXW7 NRG1 NRG1 CD81 CD81 STAP1 STAP1 CSPG4 CSPG4 IL20 IL20 FBXW9 FBXW9 DLG3 DLG3 ENSVURP00010016646 ENSVURP00010016646 HGF HGF SRC SRC EGFR EGFR CNTF CNTF LOC114030733 LOC114030733 ENSVURP00010019093 ENSVURP00010019093 IL2 IL2 IL21 IL21 ARHGEF2 ARHGEF2 CRLF1 CRLF1 PECAM1 PECAM1 LOC114049541 LOC114049541 LOC114045927 LOC114045927 LOC114049654 LOC114049654 ADAM17 ADAM17 ENSVURP00010020952 ENSVURP00010020952 ERCC6 ERCC6 PLCG2 PLCG2 IL12A IL12A CD40 CD40 ENPP2 ENPP2 ENSVURP00010022393 ENSVURP00010022393 ARL2BP ARL2BP NTF3 NTF3 ENSVURP00010023250 ENSVURP00010023250 CTF1 CTF1 TNFRSF1A TNFRSF1A CASS4 CASS4 ADNP ADNP PTPN1 PTPN1 THBS4 THBS4 LOC114032095 LOC114032095 IL18 IL18 NOD2 NOD2 ENSVURP00010026384 ENSVURP00010026384 ENSVURP00010026522 ENSVURP00010026522 ENSVURP00010026526 ENSVURP00010026526 BANK1 BANK1 IL6ST IL6ST DGKQ DGKQ IL31RA IL31RA LOC114044085 LOC114044085 FGFR3 FGFR3 DOK7 DOK7 ENSVURP00010028522 ENSVURP00010028522 ENSVURP00010028960 ENSVURP00010028960 ENSVURP00010029067 ENSVURP00010029067 LOC114049829 LOC114049829 ENSVURP00010030269 ENSVURP00010030269 HTR2A HTR2A LOC114038227 LOC114038227 TNFRSF18 TNFRSF18 IL23A IL23A ERBB3 ERBB3 NRP1 NRP1 IGF1 IGF1 MTOR MTOR IFNG IFNG ABI1 ABI1 CLCF1 CLCF1 GFRA1 GFRA1 AFAP1L2 AFAP1L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCIN1SRC kinase signaling inhibitor 1. (1208 aa)
LOC114049551SERPIN domain-containing protein; Belongs to the serpin family. (468 aa)
NEURL1Uncharacterized protein. (563 aa)
ENSVURP00010000763annotation not available (468 aa)
EPOErythropoietin. (192 aa)
IL34Uncharacterized protein. (247 aa)
ENSVURP00010001332Uncharacterized protein. (602 aa)
ENSVURP00010001704Uncharacterized protein. (60 aa)
ADRA1AAdrenoceptor alpha 1A. (439 aa)
RICTORUncharacterized protein. (1731 aa)
LOC114050566Uncharacterized protein. (215 aa)
SH2D1BSH2 domain-containing protein. (195 aa)
GDNFTGF_BETA_2 domain-containing protein. (207 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (764 aa)
ENSVURP00010003469Fibrinogen C-terminal domain-containing protein. (498 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
NEDD9SH3 domain-containing protein. (834 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
IL11Uncharacterized protein. (206 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
BMP6TGF_BETA_2 domain-containing protein. (536 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CNTN1Uncharacterized protein. (1026 aa)
ENSVURP00010005671Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (757 aa)
NCF1Uncharacterized protein. (390 aa)
PTPRCUncharacterized protein. (1300 aa)
HPXUncharacterized protein. (462 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (400 aa)
RIPK2Uncharacterized protein. (540 aa)
CSF3Uncharacterized protein. (194 aa)
HCLS1SH3 domain-containing protein. (552 aa)
ENSVURP00010007261annotation not available (60 aa)
NOX4FAD-binding FR-type domain-containing protein. (578 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (138 aa)
PARP9Uncharacterized protein. (803 aa)
EFNA5Ephrin RBD domain-containing protein; Belongs to the ephrin family. (228 aa)
ENSVURP00010008204annotation not available (602 aa)
LOC114053900Tyrosine-protein kinase. (514 aa)
ENSVURP00010008450Uncharacterized protein. (447 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SYKUncharacterized protein. (639 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
CD74Thyroglobulin type-1 domain-containing protein. (275 aa)
LTKTyrosine-protein kinase receptor. (887 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CSF1RUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
ITGA5Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1106 aa)
GREM1Gremlin. (184 aa)
ENSVURP00010012149Integrin beta; Belongs to the integrin beta chain family. (761 aa)
PIBF1Uncharacterized protein. (756 aa)
ENSVURP00010012287Uncharacterized protein. (60 aa)
LRRK1Uncharacterized protein. (2002 aa)
HBEGFEGF-like domain-containing protein. (208 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1254 aa)
EPGNEGF-like domain-containing protein. (147 aa)
EREGEpiregulin. (165 aa)
AREGEGF-like domain-containing protein. (239 aa)
MLST8WD_REPEATS_REGION domain-containing protein. (326 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
ENSVURP00010013239Uncharacterized protein. (81 aa)
LRP4Uncharacterized protein. (1913 aa)
ENSVURP00010013594Uncharacterized protein. (326 aa)
UNC119GMP_PDE_delta domain-containing protein. (145 aa)
KITUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (997 aa)
LOC114031872Tyrosine-protein kinase. (541 aa)
VTNSMB domain-containing protein. (475 aa)
LIFUncharacterized protein. (202 aa)
OSMUncharacterized protein. (206 aa)
RELNUncharacterized protein. (3459 aa)
GHRLGhrelin and obestatin prepropeptide. (113 aa)
SEMA4DUncharacterized protein; Belongs to the semaphorin family. (890 aa)
IGF2IlGF domain-containing protein. (226 aa)
TGFAEGF-like domain-containing protein. (159 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
FBXW7Uncharacterized protein. (708 aa)
NRG1Uncharacterized protein. (640 aa)
CD81Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (299 aa)
STAP1Uncharacterized protein. (302 aa)
CSPG4Uncharacterized protein. (2366 aa)
IL20Interleukin 20. (176 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
DLG3Uncharacterized protein. (366 aa)
ENSVURP00010016646Uncharacterized protein. (260 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
SRCTyrosine-protein kinase. (532 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
CNTFUncharacterized protein. (201 aa)
LOC114030733Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1043 aa)
ENSVURP00010019093annotation not available (498 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (141 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
ARHGEF2Uncharacterized protein. (1230 aa)
CRLF1Uncharacterized protein. (474 aa)
PECAM1Uncharacterized protein. (729 aa)
LOC114049541Ephrin RBD domain-containing protein; Belongs to the ephrin family. (206 aa)
LOC114045927Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
LOC114049654Uncharacterized protein. (466 aa)
ADAM17Uncharacterized protein. (824 aa)
ENSVURP00010020952HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (285 aa)
ERCC6Uncharacterized protein. (1489 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (215 aa)
CD40Uncharacterized protein. (276 aa)
ENPP2Uncharacterized protein. (936 aa)
ENSVURP00010022393ARL2_Bind_BART domain-containing protein. (119 aa)
ARL2BPARL2_Bind_BART domain-containing protein. (164 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
ENSVURP00010023250Uncharacterized protein. (188 aa)
CTF1Uncharacterized protein. (196 aa)
TNFRSF1AUncharacterized protein. (459 aa)
CASS4SH3 domain-containing protein. (846 aa)
ADNPUncharacterized protein. (1118 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (423 aa)
THBS4Uncharacterized protein. (959 aa)
LOC114032095Uncharacterized protein. (208 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (198 aa)
NOD2Uncharacterized protein. (1012 aa)
ENSVURP00010026384annotation not available (215 aa)
ENSVURP00010026522annotation not available (514 aa)
ENSVURP00010026526Tyrosine-protein kinase receptor. (552 aa)
BANK1Uncharacterized protein. (759 aa)
IL6STUncharacterized protein. (921 aa)
DGKQDiacylglycerol kinase. (895 aa)
IL31RAUncharacterized protein. (734 aa)
LOC114044085Uncharacterized protein. (2391 aa)
FGFR3Fibroblast growth factor receptor. (851 aa)
DOK7Uncharacterized protein. (589 aa)
ENSVURP00010028522annotation not available (511 aa)
ENSVURP00010028960annotation not available (206 aa)
ENSVURP00010029067annotation not available (466 aa)
LOC114049829HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
ENSVURP00010030269Tyrosine-protein kinase. (543 aa)
HTR2AG_PROTEIN_RECEP_F1_2 domain-containing protein. (469 aa)
LOC114038227Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (643 aa)
TNFRSF18Uncharacterized protein. (245 aa)
IL23AInterleukin 23 subunit alpha. (188 aa)
ERBB3Protein kinase domain-containing protein. (1338 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (922 aa)
IGF1Insulin like growth factor 1. (229 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
ABI1Uncharacterized protein. (481 aa)
CLCF1Cardiotrophin like cytokine factor 1. (222 aa)
GFRA1GDNF family receptor alpha; Belongs to the GDNFR family. (467 aa)
AFAP1L2Uncharacterized protein. (960 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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