STRINGSTRING
WNT2 WNT2 ENSVURP00010031951 ENSVURP00010031951 ENSVURP00010031201 ENSVURP00010031201 ENSVURP00010031195 ENSVURP00010031195 ENSVURP00010030401 ENSVURP00010030401 GLI1 GLI1 PIM1 PIM1 MAPK14 MAPK14 MEF2C MEF2C ENSVURP00010021762 ENSVURP00010021762 BMPR1A BMPR1A FGF2 FGF2 NOG NOG VGLL4 VGLL4 BMP10 BMP10 KCNK2 KCNK2 LOC114031681 LOC114031681 WNT2B WNT2B ZFPM2 ZFPM2 NOTCH1 NOTCH1 TBX5 TBX5 TBX20 TBX20 ENSVURP00010003534 ENSVURP00010003534 MAPK11 MAPK11 ENSVURP00010002081 ENSVURP00010002081 ENSVURP00010001006 ENSVURP00010001006
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ENSVURP00010031951Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (598 aa)
ENSVURP00010031201Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (187 aa)
ENSVURP00010031195SAM domain-containing protein. (278 aa)
ENSVURP00010030401annotation not available (591 aa)
GLI1Uncharacterized protein. (965 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
ENSVURP00010021762annotation not available (509 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
VGLL4Uncharacterized protein. (294 aa)
BMP10TGF_BETA_2 domain-containing protein. (421 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (414 aa)
LOC114031681Uncharacterized protein. (591 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
ZFPM2Uncharacterized protein. (1151 aa)
NOTCH1Uncharacterized protein. (2538 aa)
TBX5Uncharacterized protein. (518 aa)
TBX20Uncharacterized protein. (453 aa)
ENSVURP00010003534Uncharacterized protein. (80 aa)
MAPK11Mitogen-activated protein kinase. (362 aa)
ENSVURP00010002081Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSVURP00010001006Homeobox domain-containing protein. (293 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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