STRINGSTRING
HADHA HADHA EHHADH EHHADH SIRT5 SIRT5 ENSVURP00010004370 ENSVURP00010004370 HADH HADH SIRT3 SIRT3 ENSVURP00010007542 ENSVURP00010007542 ENSVURP00010007701 ENSVURP00010007701 SIRT4 SIRT4 ENSVURP00010009735 ENSVURP00010009735 HPGD HPGD SIRT7 SIRT7 ALDH1A3 ALDH1A3 SIRT1 SIRT1 CRYL1 CRYL1 SIRT2 SIRT2 SIRT6 SIRT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HADHAUncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
EHHADHUncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (334 aa)
ENSVURP00010004370Uncharacterized protein. (398 aa)
HADHUncharacterized protein. (317 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (415 aa)
ENSVURP00010007542Aldedh domain-containing protein. (204 aa)
ENSVURP00010007701Poly [ADP-ribose] polymerase. (1694 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (352 aa)
ENSVURP00010009735annotation not available (398 aa)
HPGDUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SIRT7Deacetylase sirtuin-type domain-containing protein. (404 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
SIRT1Sirtuin 1. (550 aa)
CRYL1Uncharacterized protein. (319 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (386 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (345 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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