STRINGSTRING
IL1B IL1B FRS3 FRS3 LOC114027891 LOC114027891 PIBF1 PIBF1 ENSVURP00010012149 ENSVURP00010012149 FGF1 FGF1 CADM4 CADM4 GREM1 GREM1 ENSVURP00010011377 ENSVURP00010011377 FGF8 FGF8 PDCL3 PDCL3 GDNF GDNF LOC114050566 LOC114050566 NCSTN NCSTN ESM1 ESM1 FGF9 FGF9 ENSVURP00010028893 ENSVURP00010028893 VEGFD VEGFD TIMM50 TIMM50 ENSVURP00010030660 ENSVURP00010030660 RNF41 RNF41 ATXN2 ATXN2 ENSVURP00010031932 ENSVURP00010031932 NRTN NRTN FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 FLRT3 FLRT3 ENSVURP00010009260 ENSVURP00010009260 ENSVURP00010009055 ENSVURP00010009055 JAK2 JAK2 LOC114054165 LOC114054165 LOC114053900 LOC114053900 LINGO2 LINGO2 ENSVURP00010007909 ENSVURP00010007909 ENSVURP00010007902 ENSVURP00010007902 GRAP GRAP IL5 IL5 FRS2 FRS2 FGF16 FGF16 CSF3 CSF3 TOLLIP TOLLIP ENSVURP00010006668 ENSVURP00010006668 FGF20 FGF20 ENSVURP00010006397 ENSVURP00010006397 FGF7 FGF7 FGF18 FGF18 GLMN GLMN TRIP6 TRIP6 FGF10 FGF10 LOC114043156 LOC114043156 FGF22 FGF22 RNF126 RNF126 FGF6 FGF6 FGF23 FGF23 VEGFC VEGFC TNK2 TNK2 FGF17 FGF17 PDGFRB PDGFRB ENSVURP00010010914 ENSVURP00010010914 ERAP1 ERAP1 PDGFB PDGFB IL11 IL11 ENSVURP00010004461 ENSVURP00010004461 MS4A1 MS4A1 ENSVURP00010004648 ENSVURP00010004648 IRAK4 IRAK4 CD2AP CD2AP AGR2 AGR2 LOC114030820 LOC114030820 IL36RN IL36RN IL1F10 IL1F10 IL1RN IL1RN LOC114054165-2 LOC114054165-2 ENSVURP00010026522 ENSVURP00010026522 ENSVURP00010026384 ENSVURP00010026384 NPTN NPTN ENSVURP00010025482 ENSVURP00010025482 ENSVURP00010025478 ENSVURP00010025478 ARTN ARTN PSEN1 PSEN1 CBLC CBLC PGF PGF LOC114051918 LOC114051918 ENSVURP00010021832 ENSVURP00010021832 ENSVURP00010021758 ENSVURP00010021758 IL12A IL12A SNX1 SNX1 VAV3 VAV3 ADAM17 ADAM17 SOCS5 SOCS5 ENSVURP00010019752 ENSVURP00010019752 FGF2 FGF2 IL21 IL21 IL2 IL2 GATA3 GATA3 FLRT2 FLRT2 CNTF CNTF CCDC88A CCDC88A EFEMP1 EFEMP1 PDGFD PDGFD LINGO1 LINGO1 PDGFC PDGFC ENSVURP00010015947 ENSVURP00010015947 SLC9A3R1 SLC9A3R1 ENSVURP00010015767 ENSVURP00010015767 TGFA TGFA GRB2 GRB2 MYD88 MYD88 SNX2 SNX2 LOC114040819 LOC114040819 LOC114040884 LOC114040884 FGF5 FGF5 PDCL2 PDCL2 FGF21 FGF21 PDGFRA PDGFRA ERN1 ERN1 FAM83B FAM83B VAV2 VAV2 ENSVURP00010013304 ENSVURP00010013304 AREG AREG EREG EREG EPGN EPGN PTPRJ PTPRJ CYSTM1 CYSTM1 LOC114049956 LOC114049956
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (299 aa)
FRS3IRS-type PTB domain-containing protein. (508 aa)
LOC114027891Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
PIBF1Uncharacterized protein. (756 aa)
ENSVURP00010012149Integrin beta; Belongs to the integrin beta chain family. (761 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CADM4Uncharacterized protein. (385 aa)
GREM1Gremlin. (184 aa)
ENSVURP00010011377Interleukin-1. (135 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PDCL3Phosducin domain-containing protein. (242 aa)
GDNFTGF_BETA_2 domain-containing protein. (207 aa)
LOC114050566Uncharacterized protein. (215 aa)
NCSTNNcstrn_small domain-containing protein. (707 aa)
ESM1Endothelial cell specific molecule 1. (184 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ENSVURP00010028893Uncharacterized protein. (244 aa)
VEGFDPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (354 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (375 aa)
ENSVURP00010030660Uncharacterized protein. (470 aa)
RNF41Uncharacterized protein. (317 aa)
ATXN2LsmAD domain-containing protein. (1108 aa)
ENSVURP00010031932TGF_BETA_2 domain-containing protein. (177 aa)
NRTNTGF_BETA_2 domain-containing protein. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FLRT3Fibronectin type-III domain-containing protein. (649 aa)
ENSVURP00010009260Calponin-homology (CH) domain-containing protein. (88 aa)
ENSVURP00010009055Uncharacterized protein. (171 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LOC114054165Uncharacterized protein. (303 aa)
LOC114053900Tyrosine-protein kinase. (514 aa)
LINGO2Ig-like domain-containing protein. (606 aa)
ENSVURP00010007909annotation not available (119 aa)
ENSVURP00010007902Uncharacterized protein. (119 aa)
GRAPUncharacterized protein. (217 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (138 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF3Uncharacterized protein. (194 aa)
TOLLIPCUE domain-containing protein. (290 aa)
ENSVURP00010006668Uncharacterized protein. (80 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSVURP00010006397PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (192 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GLMNUncharacterized protein. (604 aa)
TRIP6Uncharacterized protein. (464 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
LOC114043156Uncharacterized protein. (582 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (186 aa)
RNF126RING-type domain-containing protein. (313 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF23Uncharacterized protein; Belongs to the heparin-binding growth factors family. (245 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (418 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
PDGFRBUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
ENSVURP00010010914Ras-GAP domain-containing protein. (865 aa)
ERAP1Aminopeptidase. (937 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
IL11Uncharacterized protein. (206 aa)
ENSVURP00010004461Uncharacterized protein. (148 aa)
MS4A1Uncharacterized protein. (288 aa)
ENSVURP00010004648Uncharacterized protein. (247 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
CD2APUncharacterized protein. (716 aa)
AGR2Uncharacterized protein. (172 aa)
LOC114030820Interleukin-1. (163 aa)
IL36RNInterleukin-1. (153 aa)
IL1F10Interleukin-1. (152 aa)
IL1RNInterleukin-1. (175 aa)
LOC114054165-2Uncharacterized protein. (299 aa)
ENSVURP00010026522annotation not available (514 aa)
ENSVURP00010026384annotation not available (215 aa)
NPTNUncharacterized protein. (367 aa)
ENSVURP00010025482Uncharacterized protein. (177 aa)
ENSVURP00010025478annotation not available (211 aa)
ARTNTGF_BETA_2 domain-containing protein. (219 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
CBLCUncharacterized protein. (470 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (168 aa)
LOC114051918PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ENSVURP00010021832annotation not available (865 aa)
ENSVURP00010021758annotation not available (859 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (215 aa)
SNX1PX domain-containing protein. (527 aa)
VAV3Uncharacterized protein. (873 aa)
ADAM17Uncharacterized protein. (824 aa)
SOCS5Uncharacterized protein. (539 aa)
ENSVURP00010019752annotation not available (582 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (141 aa)
GATA3Uncharacterized protein. (444 aa)
FLRT2Fibronectin type-III domain-containing protein. (661 aa)
CNTFUncharacterized protein. (201 aa)
CCDC88ACalponin-homology (CH) domain-containing protein. (1902 aa)
EFEMP1Uncharacterized protein. (464 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LINGO1Ig-like domain-containing protein. (619 aa)
PDGFCUncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ENSVURP00010015947Ig-like domain-containing protein. (156 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
ENSVURP00010015767Uncharacterized protein. (102 aa)
TGFAEGF-like domain-containing protein. (159 aa)
GRB2Uncharacterized protein. (217 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (318 aa)
SNX2PX domain-containing protein. (519 aa)
LOC114040819Uncharacterized protein. (200 aa)
LOC114040884Uncharacterized protein. (196 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (273 aa)
PDCL2Phosducin like 2. (230 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
ERN1Uncharacterized protein. (974 aa)
FAM83BFAM83 domain-containing protein. (1000 aa)
VAV2Vav guanine nucleotide exchange factor 2. (758 aa)
ENSVURP00010013304annotation not available (790 aa)
AREGEGF-like domain-containing protein. (239 aa)
EREGEpiregulin. (165 aa)
EPGNEGF-like domain-containing protein. (147 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1254 aa)
CYSTM1Uncharacterized protein. (102 aa)
LOC114049956TIR domain-containing protein; Belongs to the Toll-like receptor family. (859 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
Server load: low (20%) [HD]